6 research outputs found
Cichorium intybus attenuates Streptozotocin-induced pancreatic β-cell damage by inhibiting NF-κB activation and oxidative stress
No full textNot Available
No full textNot AvailableCapsicum species are not only cultivated as vegetable and condiment crop but are also incorporated into a number of medicinal preparations in the ancient literature around the world. ‘Naga chilli’ or ‘Bhoot Jolokia’ (Capsicum chinense Jacq.) is a chilli variety indigenous to the northeast region of India and has been recognized as one of the hottest chilli in the world. It has also been used conventionally in treating various human ailments since time immemorial by the indigenous people of the northeast India. Capsaicin and dihydrocapsaicin are the two major members of the so-called capsaicinoid family, which includes other minor analogues, and usually account for at least 90 % of the pungency trait in chilli fruits. In the present study, determination of Capsaicinoid content of Bhoot Jolokia (Capsicum chinense Jacq.) under different sowing time and spacing was done. In the Scoville Organoleptic test, the highest Scoville Heat Unit (SHU) value was found in September 15 sowing fruits and the lowest in the February 15 sowing fruits. Fruit produced from spacing 105 cm × 105 cm showed highest Scoville Heat Unit. In High Performance Liquid Chromatography analysis, highest amount of capsaicinoid was also found in September 15 sowing while fruits produced from spacing 105 cm × 105 cm showed highest amount of capsaicinoid. Identification of Nordihydrocapsaicin, Capsaicin and Dihydrocapsaicin was done by comparing the retention time of sample with those of standard.Not Availabl
Low exposure long-baseline neutrino oscillation sensitivity of the DUNE experiment
No full textThe Deep Underground Neutrino Experiment (DUNE) will produce world-leading neutrino oscillation measurements over the lifetime of the experiment. In this work, we explore DUNE's sensitivity to observe charge-parity violation (CPV) in the neutrino sector, and to resolve the mass ordering, for exposures of up to 100 kiloton-megawatt-calendar years (kt-MW-CY), where calendar years include an assumption of 57% accelerator uptime based on past accelerator performance at Fermilab. The analysis includes detailed uncertainties on the flux prediction, the neutrino interaction model, and detector effects. We demonstrate that DUNE will be able to unambiguously resolve the neutrino mass ordering at a 4σ (5σ) level with a 66 (100) kt-MW-CY far detector exposure, and has the ability to make strong statements at significantly shorter exposures depending on the true value of other oscillation parameters, with a median sensitivity of 3σ for almost all true δCP values after only 24 kt-MW-CY. We also show that DUNE has the potential to make a robust measurement of CPV at a 3σ level with a 100 kt-MW-CY exposure for the maximally CP-violating values δCP=±π/2. Additionally, the dependence of DUNE's sensitivity on the exposure taken in neutrino-enhanced and antineutrino-enhanced running is discussed. An equal fraction of exposure taken in each beam mode is found to be close to optimal when considered over the entire space of interest. © 2022 authors. Published by the American Physical Society. Published by the American Physical Society under the terms of the "https://creativecommons.org/licenses/by/4.0/"Creative Commons Attribution 4.0 International license. Further distribution of this work must maintain attribution to the author(s) and the published article's title, journal citation, and DOI. Funded by SCOAP3
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No full textNot AvailableSearching rice cultivars or variety with good processing and high in important essential nutrients are prime
important in the present context of rice research. The north eastern hill region of India which is a mega
biodiversity hot spot of the world has numerous cultivars of rice with tremendous potential of high quality rice.
Eighteen indigenous cultivars of Tripura, a north eastern hill state of India were subjected to the study. Majority
of the cultivars were of short bold grain type. Eleven cultivars were aromatic type with one cultivar of strong
aroma comparable to Basmati rice. Eleven cultivars were found to possess higher hulling percentage more than
65% and six cultivars with more than 65% out turn. Majority of the cultivars had low amylose contents (<20%).
Four cultivars were having higher total crude protein (>10%), six cultivars were having higher iron contents
(>10ppm). In most of the characters, heritability (h2) was more than the genetic advance indicating more of
environmental effect. Amylose, crude fibre and iron, genetic advance was high; selection for these traits will
improve the genotypic value of selected plants over the parents. High heritability coupled with high genetic
advance was found in iron and amylose. The association of crude protein is significant but negative with
carbohydrates and amylose, while with crude fat and zinc, the association is significant and positive.
Carbohydrate was significantly and positively correlated with ash percent and iron concentration and negatively
associated with total fat. There was no significant correlation between carbohydrate and amylose.Not Availabl
Correlating the differences in the receptor binding domain of SARS-CoV-2 spike variants on their interactions with human ACE2 receptor
No full textAbstract Spike glycoprotein of SARS-CoV-2 variants plays a critical role in infection and transmission through its interaction with human angiotensin converting enzyme 2 (hACE2) receptors. Prior findings using molecular docking and biomolecular studies reported varied findings on the difference in the interactions among the spike variants with the hACE2 receptors. Hence, it is a prerequisite to understand these interactions in a more precise manner. To this end, firstly, we performed ELISA with trimeric spike glycoproteins of SARS-CoV-2 variants including Wuhan Hu-1(Wild), Delta, C.1.2 and Omicron. Further, to study the interactions in a more specific manner by mimicking the natural infection, we developed hACE2 receptors expressing HEK-293T cell line, evaluated their binding efficiencies and competitive binding of spike variants with D614G spike pseudotyped virus. In line with the existing findings, we observed that Omicron had higher binding efficiency compared to Delta in both ELISA and Cellular models. Intriguingly, we found that cellular models could differentiate the subtle differences between the closely related C.1.2 and Delta in their binding to hACE2 receptors. Our study using the cellular model provides a precise method to evaluate the binding interactions between spike sub-lineages to hACE2 receptors
Prospects for neutrino astrophysics with Hyper-Kamiokande
No full textHyper-Kamiokande is a multi-purpose next generation neutrino experiment. The detector is a two-layered cylindrical shape ultra-pure water tank, with its height of 64 m and diameter of 71 m. The inner detector will be surrounded by tens of thousands of twenty-inch photosensors and multi-PMT modules to detect water Cherenkov radiation due to the charged particles and provide our fiducial volume of 188 kt. This detection technique is established by Kamiokande and Super-Kamiokande. As the successor of these experiments, Hyper-K will be located deep underground, 600 m below Mt. Tochibora at Kamioka in Japan to reduce cosmic-ray backgrounds. Besides our physics program with accelerator neutrino, atmospheric neutrino and proton decay, neutrino astrophysics is an important research topic for Hyper-K. With its fruitful physics research programs, Hyper-K will play a critical role in the next neutrino physics frontier. It will also provide important information via astrophysical neutrino measurements, i.e., solar neutrino, supernova burst neutrinos and supernova relic neutrino. Here, we will discuss the physics potential of Hyper-K neutrino astrophysics. © Copyright owned by the author(s)
