6,053 research outputs found
An analysis of the physiological and biochemical parameters of release, storage and synthesis of transmitters from synapses onto single identifiable neurones in the brain of helix aspersa
No full textCaroline Gordon Collection
No full textArrangement Description
EXTENT
Linear Feet: 2 linear feet
Number of Containers: 2 boxes
Series 1: Writings, 31 files
Series 2: Lectures, 19 files
Series 3: Courses, 10 files
Series 4: Book Reviews, 5 files
Series 5: About Caroline Gordon,8 files
Series 6: Correspondence, 18 files
Series 7: Books, 5 books
Series 8: Media: 9 digital files, 9 cassettes, 2 reelsCOLLECTION DETAILS
<---Please open FindingAid .pdf under "FILES" to see full collection details To request any materials from this collection please email: [email protected]
BIOGRAPHICAL / Historical Note: Twentieth-century novelist Caroline Gordon was born into the Kentucky line of the extensive Meriwether family in 1895. Exploration of the family's past and its evolution is a major theme of her fiction. She grew up at Merry Mont in Todd County, near Clarksville where she received her early education. She earned a Bachelor of Arts degree from Bethany College in 1916. Her father is the idealized subject of Gordon's second novel, Alec Maury, Sportsman (1934), and the central character in her much-anthologized story, "Old Red." Gordon taught briefly; then, as a journalist, she became one of the first reviewers to comment favorably on a new Nashville-based magazine of poetry, The Fugitive. During the summer of 1924, Robert Penn Warren, a Todd County neighbor, introduced her to Allen Tate. Within a year they were married and living in New York City, where their daughter, Nancy Meriwether was born. With Tate, she began a period of life abroad, devoted to writing and sustained by various fellowships granted to one or the other. In London, Gordon was secretary to the influential British writer Ford Madox. In 1930 the Tates returned to the United States and settled in Clarksville in a house provided by Tate's brother Ben and called "Benfolly." Both Tates were exceptionally hospitable to friends and encouraging to younger writers. Both were prolific correspondents, generous with constructive criticism. (Gordon eventually became mentor to several writers, most notably Flannery O'Connor). Although she had to wrest time for her writing from domestic and social obligations, the eight Benfolly years were especially productive for Gordon, who published four novels and several stories before 1937. The first novel was Penhally (1931), followed by Alec Maury, Sportsman (1934), None Shall Look Back (1937), and The Garden of Adonis (1937), studies of the southern family during the Civil War and Great Depression. Academic appointments of the 1940s took the Tates throughout the Southeast and to Princeton, where they established a home near their daughter, who married psychiatrist Percy Wood in 1944. During this time Gordon published her fifth novel, Green Centuries (1941). Her second related group of novels, The Woman on the Porch (1944), which deals with a troubled marriage, The Strange Children (1951), based on life at Benfolly, and The Malefactors (1956), is informed by her conversion to Roman Catholicism. She and her husband wrote The House of Fiction (1950), which was followed by Gordon's How to Read a Novel in 1957. Gordon lived in Princeton until 1973, teaching, and writing: The Glory of Hera (1972). An appointment in the creative writing program drew her to the University of Dallas (Gordon was 77 years old when she proposed the new creative writing program at UD). When her health began to fail in 1978, she moved to San Cristobal de las Casas in Chapas, Mexico, with her daughter and family. She died there on April 11, 1981.
COLLECTION DESCRIPTION Caroline Gordon (1895-1981) was an American author. This collection consists of manuscripts of Gordon's work, including novels, lectures, and poetry during her time at the University of Dallas. It also includes correspondence with authors and family members, writings of others, and photographs.
Lectures and Commentary available here: https://hdl.handle.net/20.500.14026/2548University of Dalla
Large-scale phenotypic screenings of repurposing libraries to identify drugs with novel antifungal activity against candida biofilms
No full textBiofilm formation is a defining feature of many different clinical manifestations of candidiasis, as a majority of Candida species are fully capable of forming adherent cell populations. The high levels of mortality detected with Candida infections associated with a biofilm etiology make it imperative to develop new therapeutic options. Repurposing, finding new uses for old drugs, can significantly reduce the effort, time and money required in drug development, and these repositioning approaches are especially appealing in disease areas with high unmet needs and a scarcity of novel drug candidates, which is the case in the antifungal space. The availability of repurposing libraries has greatly facilitated repurposing studies by allowing the large-scale screening of hundreds to thousands of drugs in an efficient manner. Here, we present a comprehensive review of these efforts in the search for drugs with novel anti-biofilm activity against Candida species
Prevalence and influence of fungal biofilm in wound infections
No full textWound infections disrupt the normal wound healing process leading to longer treatment, hospitalisation, patient discomfort, and in extreme cases severe outcomes like amputations and death, representing one of the major challenges in the healthcare system. Biofilms represent close to 78% of these infections and while the role of bacterial pathogens and polymicrobial biofilms has been widely recognised in the field, fungi are generally ignored. This is also evident in the disproportionate focus on bacterial biofilm model development for the testing of wound therapies, with very few studies incorporating fungal species within them, all primarily focused on Candida albicans. Hence, the role of fungi in these infections in poorly understood. In this chapter, we present a summary of studies evaluating fungal prevalence in various wound types, demonstrating that not only are fungi present in wounds at a larger rate than expected but there is vast species diversity in these communities. We also provide an overview on the diagnostic methods used for fungal detection throughout these studies and their pitfalls. Finally, we discuss current developments in wound biofilm model development and the potential role of fungi in polymicrobial biofilms, highlighting the need for further research on fungi in wounds
Statement of Gordon Hirabayashi
No full textStatement by Gordon Hirabayashi about his refusal to register for forced removal to an incarceration camp. He writes: "This order for the mass evacuation of all persons of Japanese descent denies them the right to live."The ACLU-Northern California case file records contain legal documents and correspondence pertaining to the case Ex parte Mitsuye Endo (1944), in which the United States Supreme court unanimously ruled that the federal government could not indefinitely detain United States citizens who were loyal to the government. Files include documents related to the Gordon Hirabayashi Supreme Court case Hirabayashi v. United States
Evaluation of Metabolomics as Diagnostic Targets in Oral Squamous Cell Carcinoma: A Systematic Review
No full textIn recent years, high-throughput technologies have facilitated the widespread use of metabolomics to identify biomarkers and targets for oral squamous cell carcinoma (OSCC). As a result, the primary goal of this systematic review is to identify and evaluate metabolite biomarkers and their pathways for OSCC that featured consistently across studies despite methodological variations. Six electronic databases (Medline, Cochrane, Web of Science, CINAHL, ProQuest, and Embase) were reviewed for the longitudinal studies involving OSCC patients and metabolic marker analysis (in accordance with PRISMA 2020). The studies included ranged from the inception of metabolomics in OSCC (i.e., 1 January 2007) to 30 April 2023. The included studies were then assessed for their quality using the modified version of NIH quality assessment tool and QUADOMICS. Thirteen studies were included after screening 2285 studies. The majority of the studies were from South Asian regions, and metabolites were most frequently derived from saliva. Amino acids accounted for more than quarter of the detected metabolites, with glutamate and methionine being the most prominent. The top dysregulated metabolites indicated dysregulation of six significantly enriched pathways including aminoacyl-tRNA biosynthesis, glutathione metabolism and arginine biosynthesis with the false discovery rate (FDR) <0.05. Finally, this review highlights the potential of metabolomics for early diagnosis and therapeutic targeting of OSCC. However, larger studies and standardized protocols are needed to validate these findings and make them a clinical reality
102. Lance Corporal Ramage, 1915
No full textGeorge Ramage (1882-1934) enlisted as a Lance Corporal with the 3rd Gordon Highlanders on 19 January 1915. In April 1915 he was sent to Flanders where he was wounded in the left hand. He had to have his hand and the lower part of his arm amputated. He was finally discharged in August 1916. Ramage’s diary is a vivid account of what life was like for an ordinary soldier in the front-line trenches during the Great War. The following is an extract of the third volume of his diary (four volumes al..
<i>Candidozyma auris</i>: implications for infection prevention and control in the management of this resilient biofilm former
No full textCandida auris is now recognized by the World Health Organization (WHO) as a critical priority pathogen. Not only does it exhibit multidrug resistant properties, but also has the intrinsic capacity to form adherent biofilm communities in the hospital setting that impact and negatively influence clinical management. Its biological properties are primed to maintain its population within harsh environmental niches, which has supported its successful emergence on the global stage. Clinically, these behaviors and its antifungal tolerant phenotype have created an infection prevention and control problem. This chapter review will explain its clinical importance, its importance as a transmissible pathogen, and its key biological features that support biofilm growth. We will also consider why antifungal agents fail, and offer insights into how to optimally prevent and/or control these biofilms within healthcare facilities
- …
