98,824 research outputs found
RAM function is dependent on Kapβ2-mediated nuclear entry
No full textEukaryotic gene expression is dependent on the modification of the first transcribed nucleotide of pre-mRNA by the addition of the 7-methylguanosine cap. The cap protects transcripts from exonucleases and recruits complexes which mediate transcription elongation, processing and translation initiation. The cap is synthesised by a series of reactions which link 7-methylguanosine to the first transcribed nucleotide via a 5' to 5' triphosphate bridge. In mammals, cap synthesis is catalysed by the sequential action of RNGTT (RNA guanylyltransferase and 5'-phosphatase) and RNMT (RNA guanine-7 methyltransferase), enzymes recruited to RNA pol II during the early stages of transcription. We recently discovered that the mammalian cap methyltransferase is a heterodimer consisting of RNMT and the RNMT-activating subunit, RAM (RNMT-activating mini-protein). RAM activates and stabilises RNMT and thus is critical for cellular cap methylation and cell viability. Here we report that RNMT interacts with the N-terminal 45 amino acids of RAM, a domain necessary and sufficient for maximal RNMT activation. In contrast, smaller components of this RAM domain are sufficient to stabilise RNMT. RAM functions in the nucleus and we report that nuclear import of RAM is dependent on PY nuclear localisation signals and Kapß2 nuclear transport protein
Two degree of freedom motion control of an energy optimized aircraft ram air inlet actuators
No full textA high accurate position control structure for energy optimal actuation of an aircraft ram air inlet actuator is presented in this paper. The structure comprises a feedforward planning of the energy optimal reference motion profile, and a feedback position control with an inner loop for speed tracking control using a robust two degree of freedom (inverse disturbance observer) controller. The motion control structure is validated by simulation and experimental results under different load conditions
Numerical simulation of ram extrusion in short-fiber-reinforced fresh cementitious composites
No full textThis is the author's accepted manuscript. The final published article is available from the link below. First published in JoMMS in 4(10), 2009, published by Mathematical Sciences Publishers.A series of ram extrusion tests was carried out on a short-fiber-reinforced, semisolid, fresh cementitious composite. An elastoviscoplastic constitutive model is proposed for the extrudable fresh cementitious composite. It features the associative flow rule, a nonlinear strain rate-hardening law, and the von Mises yield criterion. The model is then implemented in ANSYS/LS-DYNA explicit finite element code.
Various ram extrusion processes of the fresh cementitious composite were simulated. It has been found that the extrusion load versus imposed displacement predictions agree well with the experimental results. The fresh paste flow, through the die entry and the die-land, is then interpreted in light of the evolution of the deformation and distribution of state variables, mainly based on numerical results and the ram extrusion mechanism.
The effects of extrusion ratio and extrusion velocity on extrusion load are also investigated, based on the mechanical properties of the fresh cementitious composite. The study indicates that the numerical procedure established, together with the constitutive model proposed, is applicable for describing ram extrusion of short-fiber-reinforced fresh cementitious composites, which might provide a numerical rheometric tool from which ram extrusion of elastoviscoplastic paste-like materials can be examined and quantified.Hong Kong Research Grant Council and China Ministry of Science and Technology
Scientometric portrait of Ram Gopal Rastogi
No full textPublication productivity of Indian scientist (R.G. Rastogi) has been documented.
Scientometric analysis of 312 papers by Ram Gopal Rastogi published during 1954 to 1992 in various domains: (a) Luni -solar activity and quiet -time E & F- region (57); (b) Equatorial electric field and low and mid latitude iof:osphere (78); (c) Ionospheric E- region irregularities (19); (dj Ionospheric F- region irregularities (32); and (e) Magnetic disturbance effects on the equatorial low and mid latitude ionosphere (23) were analysed. Interdomainery contents and of the number of papers: a+b were 36; b+c and b+d were 20 each; b+e were 16;. c+e were 5; a+e were 3; d+e were 2; and a+d had only one publication. Highest collaborations were with H. Chandra (61), M.R. Deshpande (42), and G. Sethia (19) out of his total 97 collaborators. His highest productivity was during 1978 with 28 papers followed by 19 papers during 1977. The core journals preferred by him for publishing papers were: Indian Journal of Radio & Space Physics, India, and Journal of Atomic & Terrestrial Physics, UK (59 each), followed by Proceedings of the Indian Academy of Sciences, India (34). Most prolific title keywords with their frequencies were: Ionosphere (92); Equatorial (61); F-region (53); Equatorial electrojet region (40), and Magnetic equator (30)
Astronomical Applications Of New Line Lists For Cn, C2 And Their Isotopologues
No full textFor cool stellar and substellar objects, atomic lines weaken, and detailed elemental and isotopic abundances are often derived from molecular absorption features. We have embarked on a project to provide molecular line lists by combining experimental observations for line positions with ab initio calculations for line strengths. So far we have results for MgH (A-X and B-X transitions)\footnote{E. GharibNezhad, A. Shayesteh and P. F. Bernath, Mon. Notices R. Astro. Soc. 432, 2043-2047 (2013)}\footnote{K. H. Hinkle, L. Wallace, R. S. Ram, P. F. Bernath, C. Sneden and S. Lucatello, Astrophys. J. Suppl. 207, 26 (7pp) (2013)}, C (Swan system)\footnote{J. S. A. Brooke, P. F. Bernath, T. W. Schmidt and G. B. Bacskay, J. Quant. Spectrosc. Rad. Trans. 124, 11-20 (2013)}\footnote{R. S. Ram, J. S. A. Brooke, P. F. Bernath, C. Sneden and S. Lucatello, Astrophys. J. Suppl. 211, 5 (7pp) (2014)}, CN (red and violet systems)\footnote{J. S. A. Brooke, R. S. Ram, C. M. Western, G. Li, D. W. Schwenke and P. F. Bernath, Astrophys. J. Suppl. 210, 23 (15pp) (2014)}, CP (A-X transition)\footnote{R. S. Ram, J. S. A. Brooke, C.M. Western and P. F. Bernath, J. Quant. Spectrosc. Rad. Transfer (in press)}, NH (vibration-rotation bands) and OH (Meinel system)\footnote{J. S. A. Brooke et al., this meeting, P301}. This talk will briefly describe the new line lists for the Swan system (d-a) of C and CC, and the red (A-X) and violet (B-X) systems of CN, CN and CN. Applications to the spectra of carbon-enhanced metal-poor stars, the K-giant Arcturus, the metal-rich open cluster NGC 6791, the Sun and comets will be presented.Made available in DSpace on 2014-09-17T16:56:06Z (GMT). No. of bitstreams: 3
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Previous issue date: 2014-06-1
A review of RAM testing methodologies
No full textThe foundations of RAM testing theory are reviewed and several test procedures designed to cover logical faults are examined in the light of experience of problems most frequently encountered. Widely used test patterns, derived on the basis of simple considerations, are analysed within the framework of the above theory. The results of this analysis, summarised in a table, provide a useful guide for the choice of the test patterns to be used for characterisation or volume testing of RAM chips
Regular inhaled short acting beta2 agonists for the management of stable chronic obstructive pulmonary disease: Cochrane systematic review and meta-analysis
No full textBACKGROUND:
Despite the lack of reversibility, patients with chronic obstructive pulmonary disease (COPD) often report symptomatic improvement with inhaled short acting beta(2) agonist bronchodilators (ISABAs) in the management of both stable and acute exacerbations of COPD. A review of the literature was undertaken to determine the effectiveness of regular treatment with ISABAs compared with placebo in stable COPD.
METHODS:
A search for randomised controlled trials was carried out using the Cochrane Collaboration database of trials up to and including May 2002.
RESULTS:
Thirteen studies of 7 days to 8 weeks in duration on 237 patients aged 56-70 years with forced expiratory volume in 1 second (FEV(1)) 60-70% predicted were included in the review. All studies used a crossover design with adequate washout periods and were of high methodological quality. ISABA was delivered either through a nebuliser or a pressurised metered dose inhaler. Spirometric tests performed at the end of the study and after the treatment (post-bronchodilator) showed a slight but significant increase in FEV(1) and forced vital capacity (FVC) compared with placebo. In addition, both morning and evening peak expiratory flow rate (PEFR) were significantly better during active treatment than during placebo. An improvement in the daily breathlessness score was observed with ISABA treatment. The risk of treatment failure was reduced by more than 50% with ISABA. Preference for ISABA was nine times higher than for placebo.
CONCLUSIONS:
Use of ISABA on a regular basis for at least 7 days in patients with stable COPD is associated with improvements in post-bronchodilator lung function and decreases in both breathlessness and treatment failure. This review has shown that regular administration of ISABAs is an effective and inexpensive treatment for the management of patients with stable COPD
Great Expectatrics: Great Papers, Great Journals, Great Econometrics
No full textThe paper discusses alternative Research Assessment Measures (RAM), with an emphasis on the Thomson Reuters ISI Web of Science database (hereafter ISI). The various ISI RAM that are calculated annually or updated daily are defined and analysed, including the classic 2-year impact factor (2YIF), 5-year impact factor (5YIF), Immediacy (or zero-year impact factor (0YIF)), Eigenfactor score, Article Influence, C3PO (Citation Performance Per Paper Online), h-index, Zinfluence, and PI-BETA (Papers Ignored - By Even The Authors). The ISI RAM data are analysed for 8 leading econometrics journals and 4 leading statistics journals. The application to econometrics can be used as a template for other areas in economics, for other scientific disciplines, and as a benchmark for newer journals in a range of disciplines. In addition to evaluating high quality research in leading econometrics journals, the paper also compares econometrics and statistics, alternative RAM, highlights the similarities and differences in alternative RAM criteria, finds that several ISI RAM capture similar performance characteristics for the leading econometrics and statistics journals while the new PI-BETA criterion is not highly correlated with any of the other ISI RAM, and hence conveys additional information regarding ISI RAM, highlights major research areas in leading journals in econometrics, and discusses some likely future uses of RAM.Research assessment measures, impact factors, Immediacy, Eigenfactor score, Article influence, h-index, C3PO, Zinfluence, PI-BETA
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