354 research outputs found
Universities and innovation in space
No full textWe investigate the role of universities as a knowledge source for regional innovation processes. The contribution of universities is tested on the level of German NUTS-3 regions (Kreise) by using a variety of indicators. We find that the intensity and quality of the research conducted by the universities have a significant effect on regional innovative output while pure size is unimportant. Therefore, a policy that wants to promote regional innovation processes by building up universities should place substantial emphasis on the intensity and quality of the research conducted there. --Universities,innovation,knowledge,spillovers,patents,regional Analysis
"War Games" by Elmer Berry, O. L. Fritsch and G. B. Affleck
No full textThis pamphlet, titled "War Games", was written by Springfield College (then known as International YMCA College) professors Elmer Berry, Otto Loren Fritsch, and George Baird Affleck. The book includes games selected to train people in different squads during World War I. It has some handwritten notes on page 3 and a drawing on page 26.Elmer Berry graduated from Springfield College in 1902 and was an instructor in anatomy, gymnastics, and athletics before receiving a MPE degree there in 1908. Later, he was a professor of physical education and physiology at the college. He received EdM and EdD degrees at Harvard University and was the author of several articles on physical education. In 1927, he was called to the National YMCA, College of Physical Education in Saidapet, Madras, India, and served as acting principal for two years. He retired from the YMCA service in 1939 after thirty-four years of service. He was a physical education professor at the State College of Washington and the University of Oregon and was presented with the Tarbell Medallion in 1947 for service.
George Baird Affleck (1876-1958) spent his boyhood in the woods of Canada, where he became an enthusiastic trapper, camper, and naturalist. He attended Manitoba Provincial Normal School (g. 1895), University of Manitoba (g. 1897), and Springfield College (g. 1901), where he played on the lawn hockey team. He worked as the Assistant Secretary of the Winnipeg YMCA from 1898-1899 and as the Physical Director of the State Teachers College (Cedar Falls, Iowa) from 1901-1907. He spent the following two years as the Physical Director of the Central Department YMCA in Chicago. In 1908, Springfield College hired Affleck, and he remained here until his retirement in 1941. Affleck was professionally affiliated with the American Student Health Association, National Education Association, College Physical Directors’ Society, AAHPRER, American Social Hygiene Association, and American Camping Association of YMCA Secretaries. For thirty years, he compiled and edited the “Selected Bibliography in Physical Education.” He wrote articles for the Association Seminar, Physical Training Magazine, Pedagogical Seminar, Camping World, Journal of Health and Physical Education, Research Quarterly, and he co-authored the Classification for Physical Education Library. In 1944, Springfield College awarded him the Tarbell Medallion, which recognizes outstanding service
Bemerkungen auf einer Reise nach der Levante : aus dem Französichen übersetzt und mit einigen erläuternden Anmerkungen begleitet /
No full textPublisher's announcements, last [8] p.Signatures: )(⁶ A-S⁸.Text by Baron von Riedesel. See Vorbericht des Übersetzers.Mode of access: Internet.Binding: marbled paper, back & corners in goatskin. Spine gilt tooled, author & title on label
Corrigendum: Sherkatolabbasieh H, Hagh-Nazari L, Shafiezadeh S, Goodarzi N, Zangeneh MM, Zangeneh A. Ameliorative effects of the ethanolic extract of Allium saralicum R.M. Fritsch on CCl4-induced nephrotoxicity in mice: A stereological examination. Arch Biol Sci. 2017;69(3): 535-43. https://doi.org/10.2298/ABS160914129S
No full textThe corresponding author of the article Sherkatolabbasieh H, Hagh-Nazari L,
Shafiezadeh S, Goodarzi N, Zangeneh MM, Zangeneh A. Ameliorative effects of
the ethanolic extract of Allium saralicum R.M. Fritsch on CCl4-induced
nephrotoxicity in mice: A stereological examination. Arch Biol Sci.
2017;69(3):535-43 has requested to change the affiliations of the authors. Link to the corrected article 10.2298/ABS160914129S</u
Gaultheria marronina sp nov (Ericaceae) from Sichuan, China
No full textGaultheria marronina, a new species from the Hengduan Mountain chain of western Sichuan Province, China, is described and illustrated. This species is similar to G. bryoides P. W. Fritsch & L. H. Zhou from the Gaoligong Mountains in its white fleshy calyx with a maroon capsule but differs in its stem setae 0.34-0.50 mm long, petioles 0.4-0.6 mm long, leaf blades 5.1-6.2 x 2.1-3.1 mm, overwintering flower bud pedicels 0.6-0.8 mm long, calyx lobes 2.2-3.0 mm long, and usually slightly open fruiting calyx, among other characters. The species is known only from two widely separated unprotected populations and is categorized as endangered
Vitae animalis morbus et medicina : suae vindicata origini disquisitione physico-medica, qua simul mechanismi et Spinosismi deliramenta, quae nunc in Wolfii placitis reviviscunt, funditus deteguntur, et mathematica evidentia ex sanae rationis circulo
No full textPreviously published as the author\u27s dissertation, Leyden, 1711. Cf. Allg. deut. Biog.; Label of the Library of the Congregation of U.B. of the Borough of Bethlehem and its vicinity. No. 616.; There is a great deal of writing on the inside front cover and the first blank pages of the volume, as well as the last blank pages and the inside rear cover. The writing appears to be references to particular pages within the text. There is no indication of the author of these notes
Entrepreneurship in the region: Breeding ground for nascent enterpreneurs?
No full textThis paper employs data from the German Socioeconomic Panel (GSOEP) and data from the German Social Insurance Statistics to study nascent entrepreneurship. In particular, micro data from the GSOEP characterizing employees and nascent entrepreneurs is combined with regional characteristics. Firstly, considering only the micro data the estimates imply that the potential drivers of nascent entrepreneurs are entrepreneurial experience, entrepreneurial learning, and parental self-employment. Secondly, accounting for regional characteristics, which measure the regional level of young and small firms or start-up activity, strongly indicate that regions with strong tradition in entrepreneurship are a breeding ground for nascent entrepreneurs. --Entrepreneurship,self-employment,young and small firms,GSOEP
De l'utilité des aménagements routiers dans l'agglomération nantaise
No full textMajor road infrastructure projects have been realized during the last twenty years in the agglomeration of Nantes (orbital motorway, highways, bridges accross the river Loire). As a new generation of Urban Transportation Plans is about to be started in major french cities, an important point at issue is the one of the estimation of social and economic utility of road infrastructure. In this paper, the author presents a mesogeographic cost-benefits analysis, for year 1994, of road infrastructure realized since 1983. Based on the classical theory of surplus, this analysis allows to estimate the time saved in car transportation due to these investments, and to produce a rate of return for the community of these new roads. Results of calculations are rather high, showing the great usefulness of these realisations. Annual time savings for car transportation are about 10 M hours, giving a rate of return about 25% .Au cours des deux dernières décennies, d’importants aménagements routiers ont été réalisés dans l’agglomération nantaise (rocade, autoroutes et voies express, franchissements de Loire) et se pose la question, à l’heure de la mise en place d’une nouvelle génération de Plans de Déplacements Urbains, de l’évaluation de l’utilité économique et sociale de ces réalisations. Cet article, en s’appuyant sur la théorie classique du surplus, propose une grille d’analyse des bénéfices que la collectivité a retiré, en 1994, des nouvelles infrastructures routières aménagées depuis 1983. Celle-ci permet d’évaluer les gains de temps, sur les déplacements en automobile, dérivés de ces aménagements et d’en déduire un taux de rentabilité pour la collectivité. Les résultats des calculs effectués sont élevés, reflétant la grande utilité des nouvelles infrastructures routières de l’agglomération. Les gains de temps annuels pour les déplacements en automobile sont de l’ordre de 10 M d’heures, donnant un taux de rentabilité économique et social d’environ 25 %.Fritsch Bernard. De l'utilité des aménagements routiers dans l'agglomération nantaise. In: Cahiers Nantais, n°53, 2000. Mélanges 2000. pp. 27-44
Durvalumab Plus Chemotherapy for Advanced Biliary Tract Cancer Treatment: Insights from the TOPAZ-1 Trial
No full textBiliary tract cancers (BTCs) are a difficult-to-treat group of tumors with an overall poor prognosis. Until 2022, combination chemotherapy was the first-line treatment standard for patients with advanced BTCs, achieving a moderate patient survival improvement. The evolution of chemoimmunotherapy has since shifted the first-line treatment landscape for advanced BTCs. In 2022, the publication of results from the pivotal phase III TOPAZ-1 trial marked a critical turning point, showing that adding durvalumab to standard chemotherapy with cisplatin and gemcitabine (CG) significantly improved overall survival in previously untreated patients with unresectable and metastatic BTCs. TOPAZ-1 marked the first major advancement in BTC treatment for more than a decade. This review summarizes the clinical evidence supporting the addition of durvalumab to CG in this indication, including the latest 3-year follow-up data from the TOPAZ-1 trial, presented at the Cholangiocarcinoma Foundation (CCF) 2024 Annual Conference and at the European Society for Medical Oncology Gastrointestinal Cancers (ESMO GI) Congress 2024, alongside real-world outcome data reflecting two years of clinical practice since FDA approval of durvalumab plus CG for first-line treatment of BTC. Additionally, we briefly touch on the underlying molecular mechanisms leading to synergy between immunotherapy and chemotherapy in BTC treatment and the potential implications for future BTC treatment strategies.
PEER REVIEWED ARTICLE
**Peer reviewers:**
Dr Antonia Digklia, Lausanne University Hospital CHUV, Lausanne, Switzerland
PD Dr Sara De Dosso, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
Received on July 22, 2024; accepted after peer review on September 19, 2024; published online on October 08, 2024
Cellular structures in Topology
No full textThis book describes the construction and the properties of CW-complexes. These spaces are important because firstly they are the correct framework for homotopy theory, and secondly most spaces that arise in pure mathematics are of this type. The authors discuss the foundations and also developments, for example, the theory of finite CW-complexes, CW-complexes in relation to the theory of fibrations, and Milnor's work on spaces of the type of CW-complexes. They establish very clearly the relationship between CW-complexes and the theory of simplicial complexes, which is developed in great detail. Exercises are provided throughout the book; some are straightforward, others extend the text in a non-trivial way. For the latter; further reference is given for their solution. Each chapter ends with a section sketching the historical development. An appendix gives basic results from topology, homology and homotopy theory. These features will aid graduate students, who can use the work as a course text. As a contemporary reference work it will be essential reading for the more specialized workers in algebraic topology and homotopy theory.</jats:p
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