132,145 research outputs found

    D. H. A. Kolff, Naukar, Rajput and Sepoy. The ethnohistory of the military labour market in Hindustan, 1450-1850

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    Champion Catherine. D. H. A. Kolff, Naukar, Rajput and Sepoy. The ethnohistory of the military labour market in Hindustan, 1450-1850. In: L'Homme, 1992, tome 32 n°121. Anthropologie du proche. p. 204

    Orthographic influences, vocabulary development and phonological awareness in deaf children who use cochlear implants

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    In the current study, we explore the influence of orthographic knowledge on phonological awareness in children with cochlear implants and compare developmental associations to those found for hearing children matched for word reading level or chronological age. We show an influence of orthographic knowledge on syllable and phoneme awareness in deaf and hearing children, but no orthographic effect on rhyme awareness. Nonorthographic rhyme awareness was a significant predictor of reading outcomes for all groups. However, whereas receptive vocabulary knowledge was the most important predictor of word reading variance in the cochlear implant group, rhyme awareness was the only important predictor of word reading variance in the reading level matched hearing group. Both vocabulary and rhyme awareness were equally important in predicting reading in the chronological age-matched hearing group. The data suggest that both deaf and hearing children are influenced by orthography when making phonological judgments, and that phonological awareness and vocabulary are both important for reading developmen

    Genetic variation at the apolipoprotein B gene and associations with coronary heart disease and its factors.

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    PhDCoronary heart disease (CED) is the major cause of mortality in Western societies. The main risk factors are plasma lipoprotein concentrations, smoking, blood pressure and family history. The effect of family history implies a genetic contribution to the aetiology, support for which has also come from twin, and other heritability studies. The genetic component of CHID may be studied by the candidate gene approach, whereby the genes of products most likely to be involved in the processes leading to CHD, and in its risk factors, are analysed. The plasma concentration of apolipoprotein (apo) B, the major protein component of low density lipoprotein (LDL), is positively correlated with the risk of developing CHD. In this research, the gene for apo B was analysed for restriction enzyme fragment length polymorphisms (RFLPs). A RFLP is caused by a sequence change in the DNA, and results in length variation in the fragments. RFLPs for apo B have been shown to be associated with CHD and the plasma concentrations of cholesterol, triglycerides and apo B in some population studies. However, other studies have failed to confirm these relations. The work described in this thesis was designed to overcome some of the problems which niay have produced these inconsistencies. A random sample of 300 men, aged 49-65 years, residing in South Wales was studied. RFLPs determined in these individuals were used to generate genotypes and haplotypes (arrangements of specific alleles on a single chromosome). Significant associations were found between some genotypes and some haplotypes with altered concentrations of plasma total cholesterol and LDL cholesterol and with risk of CHD and/or with obesity. Presence of Xbal site (X2X2 genotype) was significantly associated with higher concentrations of plasma LDL cholesterol (p=0.0 19). Absence of Mspl site (M 1) was associated with significantly elevated concentrations of plasma total and LDL cholesterol (p < 0.05) by both the techniques of genotype and haplotype analysis. EcoRl RFLP (absence of the site - El) was the minimum haplotype necessary to detect a significant association with decreased plasma cholesterol J Rajput- Williams Ph. D. Thesis Page 3 concentrations (p < 0.05). Genotypes generated from alleles defined by the Mspl-EcoRl RFLPs were associated with significant variation in serum cholesterol concentration (p < 0.03), showing a stratification of concentration with the highest being associated with loss of the Mspl site and the lowest with the presence of the EcoRl site. Both these RFLPs result in charged aminoacid alterations, and lie close to the LDL receptor binding domain of apo B. The minimum haplotype necessary for detection of apo B with CHD was Xbal-Mspl (p < 0.05). The minimum haplotype associated with obesity was the RFLP pair Pvull-Xbal (p < 0.05). Further examination for mutations of the CpG dinucleotide which may influence cholesterol metabolism was undertaken by screening around the putative LDL receptorbinding domain (RBD) of the apo B gene. One variant was detected for aminoacid residue 3500 (Arg,,,,, 4 Gln) mutation, and two variants for aminoacid residue 3611 which also corresponds to the MspI mutation (Arg,,, ,4 Gln)

    MeSH term explosion and author rank improve expert recommendations

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    Information overload is an often-cited phenomenon that reduces the productivity, efficiency and efficacy of scientists. One challenge for scientists is to find appropriate collaborators in their research. The literature describes various solutions to the problem of expertise location, but most current approaches do not appear to be very suitable for expert recommendations in biomedical research. In this study, we present the development and initial evaluation of a vector space model-based algorithm to calculate researcher similarity using four inputs: 1) MeSH terms of publications; 2) MeSH terms and author rank; 3) exploded MeSH terms; and 4) exploded MeSH terms and author rank. We developed and evaluated the algorithm using a data set of 17,525 authors and their 22,542 papers. On average, our algorithms correctly predicted 2.5 of the top 5/10 coauthors of individual scientists. Exploded MeSH and author rank outperformed all other algorithms in accuracy, followed closely by MeSH and author rank. Our results show that the accuracy of MeSH term-based matching can be enhanced with other metadata such as author rank

    Rāgs Around the Clock: A Handbook for North Indian Classical Music, with Online Recordings in the Khayāl Style

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    Rāgs Around the Clock is a rich and vibrant compendium for the discovery and study of North Indian classical music. The theory and practice of rāg are explored through two interlinked resources: a handbook of essays and analyses offering technical, historical, cultural and aesthetic perspectives; and two online albums – Rāg samay cakra and Twilight Rāgs from North India – featuring khayāl singer Vijay Rajput and accompanists.Extracts from the albums are also embedded into the text to enhance learning and understanding. Each rāg is accompanied by a description of its chief characteristics and technical features, a notation of the song (bandiś) on which the performance is based, and a transliteration and translation of the song text. Distinctively, Rāg samay cakra also includes spoken renditions of each of the texts, helping non-Hindavi speakers to achieve the correct pronunciation.Sharing insights from both theory and practice, this collection draws on recent scholarship while also showcasing the vocal idiom – the gāyakī – of Vijay Rajput, a disciple of the late Pandit Bhimsen Joshi. It offers invaluable reading for students and researchers of Indian classical music, world music and ethnomusicology, and a rich repository for teacher and student practitioners of the khayāl vocal style. The combination of an aural and written exploration of rāg will appeal to anyone drawn to this form of music – whether newcomer, student (śiṣyā) or aficionado (rasika)

    Going Beyond Counting First Authors in Author Co-citation Analysis

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    The present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed

    "Closing the R&D Gap, Evaluating the Sources of R&D Spending"

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    Both spending and tax policies have been implemented in the United States with the goal of stimulating private sector research and development (R&D). Karier questions whether current R&D policy, especially the research and experimentation tax credit, can contribute to closing the gap between nondefense expenditures on R&D in the United States and such expenditures in other countries, such as Japan and Germany. He also explores possible changes to our current R&D policy to make it more effective.

    A. D. Fricke, author

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    Black and white photograph of author, A. D. Fricke
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