1,721,018 research outputs found
Supplemental Material - PM2.5 bound polycyclic aromatic hydrocarbons in an Indian residential indoor air environment and their health risk
No full textSupplemental Material for PM2.5 bound polycyclic aromatic hydrocarbons in an Indian residential indoor air environment and their health risk by Sangita Ghatge Goel, Shashank Somwanshi, Sanjay Kashyap and Rajesh Gupta in Indoor and Built Environment.</p
sj-pdf-1-vmj-10.1177_1358863X221140151 – Supplemental material for Demographic and regional trends of peripheral artery disease mortality in the United States, 2000 to 2019
No full textSupplemental material, sj-pdf-1-vmj-10.1177_1358863X221140151 for Demographic and regional trends of peripheral artery disease mortality in the United States, 2000 to 2019 by Rochell Issa, Salik Nazir, Abdul Mannan Khan Minhas, Jacob Lang, Robert W Ariss, Waleed Tallat Kayani, Mirza Umair Khalid, Laurence Sperling, Michael D Shapiro, Hani Jneid and Rajesh Gupta in Vascular Medicine</p
Electrospray ionisation mass spectrometry of biomolecular complexes
No full textElectrospray ionisation mass spectrometry (ESI-MS) has been used to study the non-covalent interactions in dsDNA-drug complexes, a protein-protein complex of DNA polymerase III of E. coli and binding specificity of cisplatin in the formation of bifunctional adducts with DNA. ESI conditions have been developed to maximise the detection of dsDNA and drug-DNA complexes in the positive ion mode, with comparable and/or superior results to those achieved previously using negative ions. The gas phase stabilities of complexes of dsDNA with different classes of drugs have been examined. Different classes of drugs exhibit differences in sequence selectivity, modify DNA in various ways and are also known to stabilise or destabilise dsDNA. ESI-MS/MS, desolvation temperature variation, and in-source collision-induced dissociation experiments have been employed to examine the relative stabilities of drug-dsDNA complexes. The binding of complexes of a new class of metallointercalators containing Ru with dsDNA has also been examined by ESI-MS. Conditions were developed for optimal detection of these complexes in the negative ion mode and their stoichiometries and sequence selectivity have been probed. The relative order of binding affinities was found to correlate with solution studies carried out with related ruthenium compounds containing the extended planar ligands dpq, dpqC and dppz. ESI-MS has also been used to supply a snapshot of components of mixtures of two proteins (?)186 and (?) that form a complex in DNA polymerase III. The stability of the (?-?)186 complex has been studied under various solution and instrumental conditions. The behaviour of this complex was consistent with significant contribution of hydrophobic interactions to its stability, and contrasted with the previously reported behaviour of the Tus-Ter complex. In addition, ESI-MS experiments suggested that the (?) subunit is involved in stabilisatioin of (?)186. This is consistent with earlier experiments in which (?) was shown to stabilise (?) against thermal inactivation. Finally the thesis has examined binding specificity of cisplatin in the formation of bifunctional adducts at three well-characterised binding sites on ssDNA. A novel method for better reaction conditions and purification of ssDNA-cisplatin adducts HPLC has been developed. The bifunctional ssDNA-cisplatin adducts at 5-GG-3, 5-AG-3 and 5-GA-3 sites have been characterised by enzymatic digestion followed by ESI mass spectrometry for identification of binding sites. [Note: this abstract contained scientific formulae that would not come across on this form. Please see the 01Front files Abstract for the full details.
10.1177_1358863X19886374_Supplementary_material – Supplemental material for Long-term mortality after massive, submassive, and low-risk pulmonary embolism
No full textSupplemental material, 10.1177_1358863X19886374_Supplementary_material for Long-term mortality after massive, submassive, and low-risk pulmonary embolism by Rajesh Gupta, Zaid Ammari, Osama Dasa, Mohammed Ruzieh, Jordan J Burlen, Khaled M Shunnar, Hanh T Nguyen, Yanmei Xie, Pamela Brewster, Tian Chen, Herbert D Aronow and Christopher J Cooper in Vascular Medicine</p
Selected broader information technology approaches.
No full text<p>Selected broader information technology approaches.</p
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Selected uses of information technology in NTD control efforts.
No full text<p>Selected uses of information technology in NTD control efforts.</p
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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