798 research outputs found
DS_10.1177_0363546520911035 – Supplemental material for Dose-Dependent Effects of Platelet-Rich Plasma Powder on Chondrocytes In Vitro
No full textSupplemental material, DS_10.1177_0363546520911035 for Dose-Dependent Effects of Platelet-Rich Plasma Powder on Chondrocytes In Vitro by Olga Hahn, Matthias Kieb, Anika Jonitz-Heincke, Rainer Bader, Kirsten Peters and Thomas Tischer in The American Journal of Sports Medicine</p
The legacy of Ruth Bader Ginsburg
No full textL’Autrice approfondisce il personaggio ed il ruolo di Justice Ruth Bader Ginsburg secondo la prospettiva del diritto costituzionale nazionale.
Il saggio ripercorre la storia di Justice Ginsburg, occupandosi prima del suo contributo come avvocata e successivamente come giudice presso la Corte Suprema statunitense.
Attraverso l’analisi di alcune tra le sue opinions più importanti, sia di maggioranza che dissenzienti, il saggio offre un affresco del pensiero di Justice Ginsburg su alcune tematiche fondamentali sotto il profilo dei diritti e dei rapporti tra Giudice costituzionale e legislatore.
In particolare, l’A. si sofferma sulla concezione di eguaglianza promossa da Justice Ginsburg soprattutto, ma non solo, in relazione ai diritti delle donne e con riferimento al concetto di azione positiva; segue, poi, un approfondimento delle funzioni del dissent nel sistema istituzionale statunitense e un’analisi della nozione di giustizia come interpretata da Justice Ginsburg.
Il saggio si propone, quindi, di evidenziare l’eredità che Justice Ginsburg ha lasciato dietro di sè a livello globale.The Author investigates the figure and role of Justice Ruth Bader Ginsburg from a constitutional law perspective.
The paper deals with contribution of Justice Ruth Bader Ginsburg as a lawyer first and later as justice appointed to the United States Supreme Court.
By way of analysis touching upon some her most prominent majority and dissenting opinions, the A. hinges on several issues pertaining to the safeguard of fundamental rights and to the relationships between the legislator and the Constitutional Judge.
The Author then goes on by examining Justice Ginsburg’s concept of equality with respect to women’s rights and affirmative actions to then move on to an in depth focus on the role of the dissent in the US legal system and on Justice Ginsburg’s concept of justice.
At the outset, the Articles aims at highlighting the legacy of Ruth Bader Ginsburg on a global dimension
Biomechanical signals and the C-type natriuretic peptide counteract catabolic activities induced by IL-1? in chondrocyte/agarose constructs
No full textIntroduction: The present study examined the effect of C-type natriuretic peptide (CNP) on the anabolic and catabolic activities in chondrocyte/agarose constructs subjected to dynamic compression. Methods: Constructs were cultured under free-swelling conditions or subjected to dynamic compression with low (0.1 to 100 pM) or high concentrations (1 to 1,000 nM) of CNP, interleukin-1? (IL-1?), and/or KT-5823 (inhibits cyclic GMP-dependent protein kinase II (PKGII)). Anabolic and catabolic activities were assessed as follows: nitric oxide (NO) and prostaglandin E2 (PGE2) release, and [3H]-thymidine and 35SO4 incorporation were quantified by using biochemical assays. Gene expression of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), aggrecan, and collagen type II were assessed with real-time quantitative PCR (qPCR). Two-way ANOVA and the post hoc Bonferroni-corrected t tests were used to examine data. Results: CNP reduced NO and PGE2 release and partially restored [3H]-thymidine and 35SO4 incorporation in constructs cultured with IL-1?. The response was dependent on the concentration of CNP, such that 100 pM increased [3H]-thymidine incorporation (P < 0.001). This is in contrast to 35SO4 incorporation, which was enhanced with 100 or 1000 nM CNP in the presence and absence of IL-1? (P < 0.001). Stimulation by both dynamic compression and CNP and/or the PKGII inhibitor further reduced NO and PGE2 release and restored [3H]-thymidine and 35SO4 incorporation. In the presence and absence of IL-1?, the magnitude of stimulation for [3H]-thymidine and 35SO4 incorporation by dynamic compression was dependent on the concentration of CNP and the response was inhibited with the PKGII inhibitor. In addition, stimulation by CNP and/or dynamic compression reduced IL-1?-induced iNOS and COX-2 expression and restored aggrecan and collagen type II expression. The catabolic response was not further influenced with the PKGII inhibitor in IL-1?-treated constructs. Conclusions: Treatment with CNP and dynamic compression increased anabolic activities and blocked catabolic effects induced by IL-1?. The anabolic response was PKGII mediated and raises important questions about the molecular mechanisms of CNP with mechanical signals in cartilage. Therapeutic agents like CNP could be administered in conjunction with controlled exercise therapy to slow the OA disease progression and to repair damaged cartilage. The findings from this research provide the potential for developing novel agents to slow the pathophysiologic mechanisms and to treat OA in the young and old. <br/
Qualitätsentwicklung als teilnehmender und intervenierender Forschungsprozess in der Behindertenhilfe
No full textSounds Local, 1997 May 10
No full textInterview with author Ellyn Bache on her new novel, The Activist's Daughter, about young people in the 1960s; Ken Bader interviews operatic soprano singer Jayne West on performing opera vs. cabaret music; Romy and Michele's High School Reunion (film) review by WHQR's film commentator, Steve Taylor; Overview of upcoming events on the cultural calendar
Primary Stability Of Cementless Anchored Primary And Revision Cup Designs In Various Acetabular Bone Defect Situations
No full textBackground
The primary stability of cementless anchored acetabular cups is essential for the osseointegration of the implant. Factors influencing primary stability include diametral press fit, design and surface topography of the implant [1-3], bone density [4], and acetabular defect situation [5].
Objectives
Our present experimental study aims to evaluate the primary stability of primary vs. revision cup designs in various acetabular bone defects. To evaluate primary implant stability, both lever-out and torsional moments are determined in artificial bone models.
Study Design & Methods
A primary cup (Plasmafit Plus) and a revision cup design (Plasmafit Revision, both Aesculap, Tuttlingen, Germany) were tested. These were pressed into bone models (Sawbones 20 pcf, Malmö, Sweden) in a position-controlled manner using a universal testing machine (Z050, ZwickRoell GmbH & Co. KG, Ulm, Germany). The bone models represented an intact acetabular bone situation, a "medium defect" and a "large defect" situation according to Schulze et al. [5]. The specimens were evenly divided for further lever-out or torsional testing (n = 5 per group).
The lever-out test was performed using a universal testing machine by applying a force to a rod that was centrally connected to the cups. Accordingly, the bone-implant interface was loaded with a tilting moment in inferior direction. Furthermore, torsional testing was carried out with a servo-hydraulic biaxial testing machine with a constant axial load of 500 N. The torsional moment was applied to a rod, which was also centrally fixed to the cups. The lever-out and torsion tests were performed until failure of the bone-implant interface, i.e. until complete loosening of the implants occurred.
Results
The lever-out moments of the primary cup were 13.8 ± 0.8 Nm, 7.3 ± 0.6 Nm, and 5.0 ± 0.3 Nm and for the revision cup 13.7 ± 0.9 Nm, 8.6 ± 0.8 Nm, and 7.0 ± 0.7 Nm in case of the intact bone model, medium defect, and large defect situation, respectively. Hence, the revision cup achieved 17 % (medium defect) and 40 % (large defect) higher maximum lever-out moments than the primary cup.
The maximum torsional moments of the primary cup were 67.3 ± 4.3 Nm, and 51.0 ± 3.8 Nm while the revision cup showed 68.9 ± 2.3 Nm, and 56.9 ± 1.3 Nm in the case of the medium defect, and large defect situation, respectively. Within the intact bone model, the torsional moments were so high that the connection between the cup and the rod fractured. Therefore, no values were detected. Hence, the revision cup achieved 2 % (medium defect) and 12 % (large defect) higher torsional moments than the primary cup.
Conclusions
In both the lever-out and torsion tests, both cup designs showed differences in primary stability depending on the acetabular defect situation. The revision cup design led to higher lever-out and torsional moments than the primary cup in all load scenarios.
References
1 Amirouche et al. 2014, ClinBiomech, 29(10), S. 1177-1185
2 Weißmann et al. 2018, Metals, 8(10), S. 839
3 Saleh et al. 2008, AmJOrthop, 37 (10), S. 519–522
4 Schulze et al. 2019, ComputMethodsBiomechBiomedEngImaging, 22(1), S. 25–37
5 Schulze et al. 2020, J.Arthroplasty, 35(6), S. 1720-172
Kinematics and kinetics comparison of ultra-congruent versus medial-pivot designs for total knee arthroplasty by multibody analysis
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