12 research outputs found
A new species of Solaropsisfrom Amapá, Brazil (gastropoda: Solaropsidae) triggering uncertainty about the genus and redefinition of some species
No full textSilva, Fernanda S., Mendes-Júnior, Raimundo N.G., Simone, Luiz Ricardo L. (2022): A new species of Solaropsisfrom Amapá, Brazil (gastropoda: Solaropsidae) triggering uncertainty about the genus and redefinition of some species. Journal of Natural History 56 (1-4): 79-89, DOI: 10.1080/00222933.2022.2033333, URL: http://dx.doi.org/10.1080/00222933.2022.203333
Smart Household Operation Considering Bi-Directional EV and ESS Utilization by Real-Time Pricing-Based DR
No full textErdinç, Ozan (Arel Author)As the smart grid solutions enable active consumer participation, demand response (DR) strategies have drawn much interest in the literature recently, especially for residential areas. As a new type of consumer load in the electric power system, electric vehicles (EVs) also provide different opportunities, including the capability of utilizing EVs as a storage unit via vehicle-to-home (V2H) and vehicle-to-grid (V2G) options instead of peak power procurement from the grid. In this paper, as the main contribution to the literature, a collaborative evaluation of dynamic-pricing and peak power limiting-based DR strategies with a bi-directional utilization possibility for EV and energy storage system (ESS) is realized. A mixed-integer linear programming (MILP) framework-based modeling of a home energy management (HEM) structure is provided for this purpose. A distributed small-scale renewable energy generation system, the V2H and V2G capabilities of an EV together with two-way energy trading of ESS, and different DR strategies are all combined in a single HEM system for the first time in the literature. The impacts of different EV owner consumer preferences together with the availability of ESS and two-way energy trading capabilities on the reduction of total electricity prices are examined with case studies
Author Correction: Perceptions of the appropriate response to norm violation in 57 societies (Nature Communications, (2021), 12, 1, (1481), 10.1038/s41467-021-21602-9)
No full textThe original version of this Article contained an error in the author affiliations. Cecilia Reyna was incorrectly associated with ‘Universidad Nacional de Córdoba (UNC). Facultad de Psicología (UNC), Ciudad Universitaria, Bv. de la Reforma esquina, Enfermera Gordillo s/n, Córdoba, Argentina.’ instead of the correct ‘Instituto de Investigaciones Psicológicas (IIPsi), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), CABA, República Argentina.’ This has now been corrected in both the PDF and HTML versions of the Article. © The Author(s) 202
Biodiversity, threats and conservation challenges in the Cerrado of Amapá, an Amazonian savanna
No full textAn Amazonian savanna in northern Brazil known as the Cerrado of Amapá is under imminent threat from poor land-use planning, the expansion of large-scale agriculture and other anthropogenic pressures. These savannas house a rich and unique flora and fauna, including endemic plants and animals. However, the area remains under-sampled for most taxa, and better sampling may uncover new species. We estimate that only ~9.16% of these habitats have any kind of protection, and legislative changes threaten to further weaken or remove this protection. Here we present the status of knowledge concerning the biodiversity of the Cerrado of Amapá, its conservation status, and the main threats to the conservation of this Amazonian savanna. To secure the future of these unique and imperilled habitats, we suggest urgent expansion of protected areas, as well as measures that would promote less-damaging land uses to support the local population
Bioinspired and biomimetic cancer-cell-derived membrane nanovesicles for preclinical tumor-targeted nanotheranostics
No full textFunding Information: J.C. and B.M. acknowledge European Research Council grant agreement 848325 . R.P. would like to thank the Director, Indian Institute of Technology (BHU), Varanasi and the School of Biochemical Engineering, IIT (BHU) for support during preparation of this manuscript. We thank the Trident Diagnostics Center and staff for imaging and laser studies and NCCS, Pune for in vivo facilities. We would like to thank Prof. Rohit Srivastava and Dr. Sumit for their kind support. We extend our thanks to the School of Biotechnology and Kalinga Institute of Medical Sciences, KIIT, Institute of Eminence, Bhubaneswar. We dedicate this article to the memory of the late Prof. Sanjiv Sam Gambhir, a molecular imaging scientist. Figures/schemes were created with BioRender . Funding Information: J.C. and B.M. acknowledge European Research Council grant agreement 848325. R.P. would like to thank the Director, Indian Institute of Technology (BHU), Varanasi and the School of Biochemical Engineering, IIT (BHU) for support during preparation of this manuscript. We thank the Trident Diagnostics Center and staff for imaging and laser studies and NCCS, Pune for in vivo facilities. We would like to thank Prof. Rohit Srivastava and Dr. Sumit for their kind support. We extend our thanks to the School of Biotechnology and Kalinga Institute of Medical Sciences, KIIT, Institute of Eminence, Bhubaneswar. We dedicate this article to the memory of the late Prof. Sanjiv Sam Gambhir, a molecular imaging scientist. Figures/schemes were created with BioRender. J.C. and R.P. conceived the idea. M.G. G.C.K. R.P. and J.C. designed the experiments. M.G. G.C.K. R.P. and N.G. performed in vivo imaging and therapeutics studies. B.P. and E.H.A.W. conducted the western blots. B.P. and H.Q. performed the simulation studies. R.P. B.M. and J.C. wrote the paper. All authors contributed to final editing and multiple revisions of the present manuscript. J.C. is a co-founder and shareholder of TargTex S.A. R.P. is part of national and international patents related to lipid, gold, silica, and erythrocyte-based nanoparticles. Publisher Copyright: © 2023 The Author(s)Bioinspired cell-membrane-camouflaged nanohybrids have been proposed to enhance tumor targeting by harnessing their immune escape and self-recognition abilities. In this study, we introduce cancer-cell-derived membrane nanovesicles (CCMVs) integrated with gold nanorods (AuVNRs) in addition to therapeutic and imaging cargos such as doxorubicin and indocyanine green. This approach enhances targeted tumor imaging and enables synergistic chemo-phototherapeutics for solid tumors. CCMVs demonstrate significant tumor penetration and retention, serving as nanotheranostics with accessible surface biomarkers, biomimicking properties, and homologous targeting abilities. By evading uptake by the mononuclear phagocytic system, CCMVs can diffuse into the deep tumor core, leading to precise tumor reduction while preserving the surrounding healthy tissues. Notably, intravenous administration of these theranostic agents ensures biocompatibility, as evidenced by a survival period of approximately two months (up to 63 days) without any observed side effects. Our findings underscore the diagnostic and therapeutic potential of this biomimetic nanotheranostics platform.publishersversionpublishe
Slow Magnetic Relaxation In Coiicuii Coordination Oligomer Built Into Mesoporous Material
No full textThe ferrimagnetic system CoCu(opba) [opba = ortho-phenylenebis( oxamato)] was employed to prepare a traditional chain [CoCu(opba)]·4H2O (1) and a nanocomposite by incorporation in porous Vycor glass (PVG). This nanocomposite was made by first anchoring [Bu4N]2[Cu(opba) ] on PVG [PVG-Cu (2)] and then treating it "in situ" with cobalt(II) acetate to obtain the nanomagnet PVG-CuCo (3). Magnetic measurements show that 1 consists of a one-dimensional ferrimagnet with strong intrachain antiferromagnetic coupling and weak interchain interactions that result in spin-glass behavior below 3.5 K. Nanocomposite 3 presents ferrimagnetic chains limited by the nanopore size, which leads to a slow relaxation of the magnetization following Arrhenius' law, frequency dependence for in-phase and out-of-phase susceptibility, and hysteresis below the blocked regime temperature (< 6 K). These features are characteristics of single-chain magnets (SCM). © Wiley-VCH Verlag GmbH & Co. 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Croton sertanejus Sodre & M. J. Silva 2022, sp. nov.
No full textCroton sertanejus Sodré & M.J.Silva sp. nov. urn:lsid:ipni.org:names:77305496-1 Figs 1–2 Diagnosis Croton sertanejus sp. nov. differs from C. echioides due to pseudomonopodial branching, with an elongated main stem with shortened secondary branches in an alternate arrangement (vs di- or trichotomous branching in C. echioides), petiole 0.4–1.7(–2) cm long (vs (1.8–) 3–8.1 cm), leaf blade base with 4–6 subsessile nectary glands facing both surfaces (vs with 2 stipitate nectary glands facing the abaxial surface), equal pistillate sepals (vs subequal or strongly unequal), and styles 2–3 mm long (vs 4–5.5 mm). Etymology ʻ Sertanejo ʼ, in Portuguese, refers to people native to the Caatinga region, also known as ʻ sertão ʼ, that extends to all the states of northeast Brazil and the northern Minas Gerais. Material examined Type BRAZIL • Bahia, Oliveira dos Brejinhos, 6 km ao Sul da cidade pela vicinal “ Corredor da Barra ”; 12°22′02.7″ S, 42°54′14.3″ W; 884 m a.s.l.; 20 Dec. 2017; fl.; R. C. Sodré, A. O. Souza & U.S. Amaral 3350; holotype: BOTU; isotypes: CEPEC, NY, TEPB, UFG. Paratypes BRAZIL – Bahia • Barra, Conglomerado BA-360; 10°58′48″ S, 44°33′36″ W; 20 Dec. 2017; fl.; A.S. Soares 401; RB, UB • Barra do Mendes, Carretão, estrada para Canarina; 11°49′33″ S, 42°3′17″ W; 750 m a.s.l.; 15 Dec. 2009; fl.; E. Melo, F. França & B.M. Silva 7505; ALCB, HUEFS • ibid.; E. Melo, F. França & B.M. Silva 7507; HUEFS • ca 10 km na estrada de terra para Seabra; 11°53′41″ S, 42°2′53″ W; 750 m a.s.l.; 16 Dec. 2009; fl.; E. Melo, F. França & B.M. Silva 7539; HUEFS • ibid.; E. Melo, F. França & B.M. Silva 7541; ALCB, HUEFS • ca 16.5 km na estrada de terra para Seabra, Lagoa do Peixe; 11°56′22″ S, 42°2′3″ W; 743 m a.s.l.; 16 Dec. 2009; fl.; E. Melo et al. 7563; HUEFS • ca 27 km na estrada de terra para Seabra; 12°1′13″ S, 41°59′58″ W; 750 m a.s.l.; 16 Dec. 2009; fl.; E. Melo, F. França & B.M. Silva 7580; ALCB, HUEFS • Brotas de Macaúbas, estrada para a BR-242; 12°17′7″ S, 42°34′7″ W; 519 m a.s.l.; 30 Jan. 2008; fl.; J.L. Ferreira, E. Melo & B.M. Silva 266; HUEFS • ibid.; J.L. Ferreira, E. Melo & B.M. Silva 268; HUEFS • Brumado; 28 Oct. 1965; fl.; A.P. Duarte 9544; HUEFS, NY, RB, SPF • Caetité; 15 Jan. 1983; fl.; M.L. Guedes et al. 2787; ALCB • ramal a 29 km na estrada Caetité/Brumado, ca 3 km ramal adentro; 19 Feb. 1992; fr.; A.M. Carvalho et al. 3784; CEPEC, NY • Campo Formoso; 21 Apr. 1981; fr.; W.N. Fonseca 386; RB • Canudos, Bedengó, Ramal a 5 km da BR-115, sentido Euclides da Cunha; 10°4′42″ S, 39°7′46″ W; 560 m a.s.l.; 24 Jun. 2005; no fl. or fr.; D.S. Carneiro-Torres et al. 514; HUEFS • Carfanaum, entre Lapa Cercada e Lapa da Igreja, proximidades do povoado de Cercadinho; 11°44′17.71″ S, 41°27′20.55″ W; 748 m a.s.l.; 19 Mar. 2016; fl. and fr.; P.H.A. Melo & F.F. Pezzini 4885; HUEFS • ibid.; 11°44′2.4″ S, 41°27′41.7″ W; 731 m a.s.l.; 9Apr. 2017; fl.; P.H.A. Melo & L.C.A. Gonçalves 6744; HUEFS • ibid.; P.H.A. Melo & L.C.A. Gonçalves 6752; HRCB • margem esquerda da BR-122, a 22 km de Cafarnaum, sentido Morro do Chapéu; 11°31′58.7″ S, 41°23′12.2″ W; 737 m a.s.l.; 10 Apr. 2017; fl.; P.H.A. Melo & L.C.A. Gonçalves 6783; HRCB, HUEFS • ibid.; P.H.A. Melo & L.C.A. Gonçalves 6792; HRCB, HUEFS • ibid.; P.H.A. Melo & L.C.A. Gonçalves 6794; HRCB, HUEFS • Contendas do Sincorá, estrada entre Sussuarana e Contendas do Sincorá; 13°48′56″ S, 41°3′57″ W; 404 m a.s.l.; 15 Mar. 2015; fr.; A.G. Azevedo-Neto et al. 14; HUEFS • Curaçá, Comunidade de Patamuté; 9°25′19″ S, 39°28′13″ W; 420 m a.s.l.; 23 Mar. 2012; fl.; E. Melo et al. 11078; HUEFS • Glória, Complexo Itaparica, margem do lago; 9°4′11″ S, 38°24′13″ W; 333 m a.s.l.; 14 Jun. 2007; fl.; M. Oliveira et al. 2831; MAC, UFP • Iaçu, Fazenda Lapa, Lagedo Alto; Apr. 1974; fl.; G.C.P. Pinto 42272; ALCB • rodovia Itaberaba/Milagres, entre Iaçu e Milagres, a 10–20 km a E de Iaçu, 400–500 m a.s.l.; 25 Dec. 1979; fl.; S.A. Mori & F.P. Benton 13243; CEPEC, NY • BA-046, trecho entre Milagres e Iaçu, a 25 km ao SE de Iaçu, 300 m a.s.l.; 28 Feb. 1980; fl. and fr.; S.A. Mori 13272; CEPEC, NY • Fazenda Lapa; 12°42′ S, 39°56′1 W; 26 Feb. 1983; fl. and fr.; H.P. Bautista 716; HUEFS • Fazenda Suíbra, Morro do Gado Bravo; 12°43′ S, 40°7′ W; 14 Mar. 1985; fl. and fr.; L.R. Noblick 3687; CEPEC, HUEFS • rodovia Iaçu/Milagres (BA-046) km 13, coletas no início do ramal para as fazendas Suíbra e Morros; 12°49′ S, 40°10′ W; 240 m a.s.l.; 22 Mar. 1988; fl.; S. Ginzbarg, L.A. Mattos-Silva & H.S. Brito 803; CEPEC, NY • Morro da Garrafa; 12°45′18″ S, 39°51′0″ W; 250 m a.s.l.; 23 Feb. 1997; fr.; E. Melo et al. 2116; HUEFS, HUESB, SP • Ibipeba, estrada para Ibititá; 11°37′6″ S, 42°0′3″ W; 742 m a.s.l.; 25 Oct. 2009; fr.; E. Melo et al. 6881; ALCB, HUEFS • Irecê, Lapão, Morro Pelado; 11°24′22″ S, 41°49′22″ W; 787 m a.s.l.; 27 Oct. 2009; fr.; M.L. Guedes et al. 16178; ALCB, HUEFS • Área do CETEP; 11°19′0″ S, 41°49′49″ W; 22 Feb. 2016; fl. and fr.; G. Costa & A.C.S. Moraes 1656; ALCB, HUEFS, HURB • 11°19′0″ S, 41°49′42″ W; 25 Feb. 2016; fr.; G. Costa & A.C.S. Moraes 1742; ALCB, HUEFS, HURB • ibid.; G. Costa & A.C.S. Moraes 1746; ALCB, HUEFS, HURB • Itatim, Morro do Agenor; 12°43′ S, 39°46′ W; 310–430 m a.s.l.; 25 Feb. 1996; fl.; E. Melo et al. 1483; CEN, HUEFS, MAC • Morro da Quixaba; 12.7119° S, 39.6981° W; 410 m a.s.l.; 14 Dec. 1996; fl.; E. Melo et al. 1889; HUEFS, SP, VIES • Morro do Bastião; 12°45′12″ S, 39°46′59″ W; 282 m a.s.l.; 25 Jan. 1997; fl.; E. Melo et al. 1919; HUEFS, HUESB, UEC • ibid.; 24 May 1997; fl.; V.M. Monteiro, C. Aguiar & J. Resende 68; HUEFS • Itiúba, Serra de Itiúba, about 6 km E of Itiúba; 10°41′ S, 39°48′ W; 500 m a.s.l.; 19 Feb. 1974; fl.; R.M. Harley 16214; RB • Fazenda Experimental da EPABA; 10°43′ S, 39°48′ W; 27 May 1983; fl. and fr.; G.C.P. Pinto & H.P. Bautista 109/83; CEPEC, K, NY • 10 km da cidade de Itiúba; 10°41′14″ S, 39°48′17″ W; 24 Jun. 2005; no fl. or fr.; D.S. CarneiroTorres et al. 531; HUEFS • Ituaçu, Morro da Mangabeira; 22 Dec. 1983; fl.; E.P. Gouveia 60/83; ALCB • ibid.; E.P. Gouveia s.n.; ALCB [51564[• Jacobina; 8 Apr. 1991; fr.; M. Andrade Neto s.n.; EAC [17121], K [001184431], NY [01281082] • Jaguari, Fazenda Pé de Laje, próximo ao povoado de Gameleira; 10°12′52.4″ S, 40°8′8.2″ W; 644 m a.s.l.; 18 Apr. 2017; fl.; E.D.S. Almeida & J.G.B. Silva 81; HVASF, HUEFS • Jeremoabo, estrada de chão sentido Canudos; 10°4′7″ S, 38°28′21″ W; 297 m a.s.l.; 30 Jun. 2007; no fl. or fr.; D.S. Carneiro-Torres et al. 981; HUEFS • Jequié, estrada da Barragem de Pedra; 5 Apr. 1987; fl.; V. Pereira 99; HUEFS • Juazeiro, Serra do Mulato; 9°44′40″ S, 40°40′39″ W; 26 Mar. 2000; fl.; N.G. Jesus et al. 880; ALCB, SPF • Lagoa Real; 565 m a.s.l.; 17 Dec. 2008; fl.; C. Novello 1; HUEFS, HUEM • ibid.; C. Novello 2; HUEFS, HUEM • Lajedinho, proximidade do povoado de Simpatia; 12°27′7.36″ S, 41°0′41.52″ W; 593 m a.s.l.; 17 Mar. 2016; fl.; P.H.A. Melo & F.F. Pezzini 4833A; HRCB • 12°27′18.9″ S, 41°0′33.3″ W; 591 m a.s.l.; 8 Apr. 2017; fl.; P.H.A. Melo & L.C.A. Gonçalves 6691; HUEFS • ibid.; P.H.A. Melo & L.C.A. Gonçalves 6734; HRCB, HUEFS • Livramento do Brumado, 3–5 km da cidade, na estrada para Rio de Contas; 13°38′ S, 41°50′ W; 580–600 m a.s.l.; 12 Dec. 1988; fl.; R.M. Harley et al. 27140; CEPEC • ibid.; R.M. Harley et al. 27141; K, NY, SPF • Manoel Vitorino, estrada que liga Manoel Vitorino com Caatingal, a 5 km da BR-116; 350 m a.s.l.; 10 Mar. 1980; fr.; S. Mori 13448; CEPEC, NY • Maracás, estrada para Marcionílio Souza, ca 12.6 km da cidade; 13°14′20″ S, 40°34′15″ W; 395 m a.s.l.; 3 Nov. 2011; fl.; E. Melo et al. 10603; HUEFS • Marcionílio Souza, 8 km ao S de Marcionílio Souza na estrada para Maracás; 13°5′ S, 40°30′ W; 22 Mar. 1988; fl.; S. Ginzbarg, L. A. Mattos-Silva & H. S. Brito 816; NY • Monte Santo; 10°26′ S, 39°19′ W; 11 Jan. 2006; fl.; M. L. Guedes et al. 12037; ALCB • ibid.; 22 Jan. 2016; fl.; F. A. Silva 18; HURB • Morpará; 11°35′50″ S, 43°17′4″ W; 16 Dec. 2007; fl.; A. A. Conceição et al. 2652; HUEFS • estrada para Morpará, beira do Rio Paramirim; 11°42′11″ S, 43°14′2″ W; 444 m a.s.l.; 16 Dec. 2007; fl.; A. A. Conceição et al. 2682; HUEFS • ibid.; A. A. Conceição et al. 2686; HUEFS • Morro do Chapéu, ca 2 km da Comunidade Gruta dos Brejões; 11°0′53″ S, 40°24′19″ W; 650 m a.s.l.; 4 May 2007; no fl. or fr.; D. Cardoso & R. M. Santos 1820; HUEFS • estrada para Cafarnaum; 11°29′50″ S, 41°21′34″ W; 728 m a.s.l.; 1 Feb. 2008; fl.; F. B. L. Silva & F. França 78; HUEFS • Oliveira dos Brejinhos, estrada para Água Quente; 12°20′11″ S, 42°54′29″ W; 673 m a.s.l.; 18 Dec. 2007; fl.; A. A. Conceição et al. 2759; HUEFS • 6 km ao Sul da cidade pela vicinal “Corredor da Barra”; 12°22′02.7″ S, 42°54′14.3″ W; 884 m a.s.l.; 20 Dec. 2017; fl.; R. C. Sodré et al. 3347; BOTU, UFG • ibid.; R. C. Sodré et al. 3348; BOTU, UFG • ibid.; R. C. Sodré et al. 3349; BOTU, UFG • Palmeiras, 12°26′48″ S, 41°31′6″ W; 697 m a.s.l.; 1 Dec. 2011; fl.; S. P. S. Neves 393; HUEFS • subida para a Serra Negra; 12°32′ S, 41°35′ W; 740 m a.s.l.; 29 Jan. 2015; fl.; D. S. Carneiro-Torres et al. 1288; HUEFS • 12°31′51.6″ S, 41°35′17.4″ W; 736 m a.s.l.; 19 Dec. 2017; fl.; R. C. Sodré et al. 3341; UFG • Paulo Afonso; 12 Apr. 1952; fl.; Labouriau 941; RB, SPF • Piatã, Chapada Diamantina, subida da Capela Nossa Senhora Santana; 13°9′2″ S, 41°45′0″ W; 15 Jun. 2014; fl.; M. L. Guedes et al. 21918; ALCB • Piemonte da Diamantina, Miguel Calmon, entorno do Parque de Sete Passagens; 11°22′25″ S, 40°35′14″ W; 546 m a.s.l.; 23 Dec. 2006; fl.; M. L. Guedes et al. 13215; ALCB • João Dourada, Ponto 7; 11°19′51″ S, 41°44′14″ W; 363 m a.s.l.; 10 Apr. 2013; fl.; M. L. Guedes et al. 20656; ALCB • Pilão Arcado, sentido Brejo de Zacarias; 9°58′31″ S, 42°49′12″ W; 6 Sep. 2005; no fl. or fr.; D. S. Carneiro-Torres et al. 593; HUEFS • sentido Iú Grande – Pilão Arcado Dunas, Barra do Iú; 10°1′25″ S, 42°48′15″ W; 18 Mar. 2006; fr.; D. S. Carneiro-Torres et al. 621; HUEFS • Quijingue, fazenda Urubu, a ca de 3 km E do povoado Quixaba do Mandacaru; 10°55′1″ S, 39°3′49″ W; 270 m a.s.l.; 14 May 2005; fr.; D. Cardoso 515; HUEFS, NY • Remanso, ca 18 km de Remanso, entrada a direita no sentido Remanso; 9°29′20″ S, 42°14′54″ W; 457 m a.s.l.; 28 Dec. 2001; fl.; T. S. Nunes et al. 690; HUEFS • Rio de Contas, 10 km do Rio de Contas na estrada para Marcolino Moura; 13°36′ S, 41°43′ W; 500–600 m a.s.l.; 15 Nov. 1988; fl.; R. M. Harley, D. J. N. Hind & T. B. Cavalcanti 26445; K, NY, RB, SPF, U • caminho para Lagoa Nova; 13°47′42″ S, 41°46′44″ W; 490 m a.s.l.; 5 Feb. 1997; fr.; E. Saar et al. PCD 5093; ALCB, K, SPF • ibid.; fl. and fr.; L. Passos et al. PCD 5109; ALCB, CEPEC, K, SPF • São Gabriel, fazenda Boa Sorte; 11°1′ S, 41°39′ W; 798–800 m a.s.l.; 3 Apr. 2009; fl.; R. F. Machado, F. F. Rocha & A. F. Rocha 138; HUEFS • estrada para Jussara; 11°9′54″ S, 41°56′34″ W; 770 m a.s.l.; 25 Oct. 2009; fl. and fr.; E. Melo et al. 6956; ALCB, HUEFS • Senhor do Bonfim, Fazenda Rancharia; 24 Mar. 2007; fl.; L. P. Felix 11562; HUEFS • ibid.; L. P. Felix 11581; HUEFS • Sento Sé, base do Morro da Mina; 9°51′39″ S, 42°3′23″ W; 930 m a.s.l.; 19 Dec. 2007; fl. and fr.; J. G. Carvalho-Sobrinho & C. T. Lima 1728; HST, HUEFS • Umburanas, Ourolândia, estrada para Umburanas, estrada de chão para Pedreira Araras; 10°56′57″ S, 41°4′38″ W; 682 m a.s.l.; 26 Jan. 2008; fl.; M. M. Silva-Castro et al. 1435; HUEFS • Parque Nacional Boqueirão da Onça, rio Murim; 10°30′16.9″ S, 41°19′52.4″ W; 744 m a.s.l.; 29 Jan. 2010; fr.; A. P. Fontana et al. 6426; HUEFS, HVASF • Xique-Xique, 15 km S de Xique-Xique, camino a Santo Inácio; 10°58′ S, 42°41′ W; 400–500 m a.s.l.; 19 Feb. 1997; fr.; M. M. Arbo et al. 7519; CEPEC, CTES, NY. – Ceará • Aiuaba; 6.3712° S, 40.0923° W; 478 m a.s.l.; 21 Feb. 2014; fl.; A. L. B. Sartori et al. 1153; EAC • Campos Sales, Várzea da Vaca; Feb. 1839; fl.; G. Gardner 2441; K [001184426], K [001184427], L [0146109] • Piquet Carneiro, Ibicuã, Miguel Calmon; 17 Apr. 1909; no fl. or fr.; A. Ducke s.n.; MG [2202], RB [187679] • Saboeiro, entre Saboeiro e Aiuaba, no entroncamento da estrada do Algodão; 21 Mar. 1984; fl.; E. Nunes s.n.; EAC [12357], HUEFS [111120] • Tauá, Fazenda Angico; 29 Apr. 1981; fr.; E. Nunes & M. A. Figueiredo s.n.; EAC [10110], HUEFS [106374]. – Minas Gerais • Mato Verde, São João do Bonito, estrada para as lavras na Serra Geral, 2.5 km de São João do Bonito, 12.5 km da rodovia Mato Verde – Monte Azul (BR-122), próximo ao Córrego do Pé da Serra; 15°18′21″ S, 42°49′37″ W; 580 m a.s.l.; 7 Apr. 2004; fl. and fr.; J. R. Pirani et al. 5466; SPF. – Paraíba • Itaporanga, Fazenda Cafula; 7°13′52″ S, 38°9′21.6″ W; 540 m a.s.l.; 2 Nov. 2015; fl.; P. F. Souza 107; CSTR, EAC • São José dos Cordeiros, RPPN-Fazenda Almas; 7°28′15″ S, 36°53′51″ W; 645 m a.s.l.; 24 Jan. 2003; fl.; Z. G. Quirino & J. R. Lima 3; HUEFS • ibid.; Z. G. Quirino & J. R. Lima 15; HUEFS • Manga geral, Área I, Laje do Cara; 7°29′21″ S, 36°55′36″ W; 16 Feb. 2003; fl.; M. R. Barbosa et al. 2686; HUEFS, JPB • ibid.; M. R. Barbosa et al. 2715; HUEFS, JPB • Taperoá, 5 km após a entrada da estrada para Taperoá; 4 Mar. 1994; fl. and fr.; S. I. da Silva s.n.; PEUFR, SPF [137104]. – Pernambuco • Afogados da Ingazeira, estrada para Afogados da Ingazeira, km 35 da BR-292; 10 Feb. 1993; fl.; S. I. da Silva 64; PEUFR, SPF • Betânia, Vale dos Navios; 20 Apr. 1955; fl.; A. Guerra 5528; SPF • Vale do Pajéu; 5 Apr. 2002; fr.; S. M. Freitas Neto et al. 1; HUEFS • Bodocó, arredores da cidade; 12 Feb. 1991; fl.; P. Lisboa & C. Silva 4515-34; EAC • Buíque, fazenda Laranjeiras; 8°37′30″ S, 37°9′15″ W; 799 m a.s.l.; 22 Feb. 1996; fl.; K. Andrade et al. 306; NY, PEUFR • Custódia, proximidades do Reservatório Copiti, Projeto de Transposição do Rio São Francisco; 8°14′53.9″ S, 37°41′33.3″ W; 526 m a.s.l.; 18 Feb. 2009; fl.; M. Oliveira & J. Cardoso Junior 3763; HVASF, HUEFS • estrada formada pela área de influência da linha de transmissão de alta tensão que acompanha o canal do PISF; 8°12′16.48″ S, 37°41′52.1″ W; 434 m a.s.l.; 14 May 2013; fr.; V. M. Cotarelli & J. Silva 2530; HVASF, HUEFS • ibid.; 8°9′55.6″ S, 37°33′20.32″ W; 513 m a.s.l.; 15 Mar. 2016; fl. and fr.; M. Oliveira, A. P. Fontana & A. C. P. Oliveira 6407; RB • Lagoa Grande, Sertão, Fazenda Planaltino, Rodovia PE-574; 8°59′ S, 40°16′ W; 10 Jan. 2018; fl.; M. L. Guedes 30231; ALCB • Petrolândia, trecho do canal da transposição; 8°41′32.6″ S, 38°16′28.3″ W; 391 m a.s.l.; 29 Jan. 2009; fl. and fr.; V.D. Silva et al. 87; HUEFS, HVASF • Petrolina, limite sul do CPATSA; 9°7.5′ S, 40°31.11′ W; 13 Jan. 1983; fl.; G. Fotius 3304; HTSA, RB • ibid.; 24 Jan. 1983; fl.; G. Fotius 3310; HTSA, RB • área da CODEVASF; 9°9.17′ S, 40°29.44′ W; 4 Feb. 1983; fl.; G. Fotius 3333; HTSA, RB • CPATSA; 3 Mar. 1993; fl.; S. I. da Silva 114; PEUFR, SPF • Salgueiro; 9 Mar. 2007; fr.; E. R. Silveira s.n.; EAC [39845] • ibid.; 8°7′ S, 39°7′ W; 3 Mar. 2014; fr.; E. R. Silveira & F. C. L. Pinto s.n.; ALCB [122233] • Santa Maria da Boa Vista, margem da PE 4 em direção à Jutaí; 29 Apr. 1971; fr.; Academia Brasileira de Ciências 406; HUEFS, IPA • Serra Talhada, Estação Experimental do IPA, Pimenteira; 25 Mar. 1995; fl.; A. M. Miranda et al. 2192; MAC, PEUFR, SPF • ibid.; 7.59° S, 38.1916° W; 30 Jan. 1996; fl.; M. L. Gomes 129; IPA, HUEFS • 3 km SW of road from Serra Talhada to Lagoinha, around permanent plot and flux tower; 7°58′5″ S, 38°23′3″ W; 17 Mar. 2017; fl.; P. W. Moonlight & T. Sarkinen 419; HUEFS • ibid.; 18 Mar. 2017; fl.; P. W. Moonlight & T. Sarkinen 430; HUEFS • Sertânia, Centro da Caprino-ovinocultura do IPA, Pimenteira; 8°4′25″ S, 37°12′24″ W; 160 m a.s.l.; 6 Apr. 2001; fl. and fr.; R. M. Harley & A. M. Giulietti 54177; HUEFS, K • Caroalina, Sítio do Sr. Sibas; Jul. 2003; fl.; L. Melo & J. Sampaio 34; IPA, HUEFS • Verdejante, Vila Produtiva Rural de Pilões; 7°52′57.23″ S, 39°2′16.13″ W; 534 m a.s.l.; 21 Feb. 2013; fl.; F. F. S. Silva 751; HUEFS, HVASF. – Piauí • São João do Piauí, Porfírio; 8°21′ S, 42°14′ W; 222 m a.s.l.; 14 Feb. 1995; fl. and fr.; F. G. Alcoforado Filho 477; HUEFS, IPA, K, TEPB • ibid.; 14 Apr. 1995; fl. and fr.; F. G. Alcoforado Filho & J. H. Carvalho 484; IPA, K, TEPB • Embrapa Meio Norte; 8°20′44″ S, 42°19′34″ W; 24 Mar. 2015; fl. and fr.; K. N. C. Castro & J. B. A. Souza 471; CEN • São Raimundo Nonato, Humaitá – São Raimundo Nonato; 15 Dec. 1978; fl.; F. M. T. Freire 11; EAC • Barreirinhas – São Raimundo Nonato; 18 Dec. 1978; fl.; A. Fernandes et al. s.n.; EAC [5151] • fazenda Joá; 27 Jan. 1984; fl.; L. Emperaire 2180a; RB • Parque Nacional Serra da Capivara; 8°25′ S, 42°20′ W; 8 Dec. 2017; fl.; M. Mizushima, P. Rodrigues & R. M. Santos 218; HUEFS. – Sergipe • Poço Verde, Fazenda Santa Maria da Lage; 10°42′30″ S, 38°11′0″ W; 16 Nov. 2010; no fl. or fr.; E. V. R. Ferreira et al. 213; ASE • Assentamento Santa Maria da Lage; 22 Jul. 2015; fr.; E. V. S. Oliveira 563; ASE, HUEFS • locality unknown [caatingas arbustivo-arbórea e arbórea]; Apr. 1989; fl. and fr.; E. L. Araújo s.n.; SPF [137105]. Description Shrubs or trees, (1–)1.5–5(–7) m tall, erect, pseudomonopodial branching, with main stem extended bearing lateral alternate branches, frequently with galls; latex scarce, clear; sweetish odor; stems very rigid, cylindric, straight or tortuous, striated or smooth in young branches; whitish, yellowish, or slightly ferrugineous tomentose indumentum of multiradiate or stellate-porrect trichomes with stipe 0.05–0.1 mm long, stellate-porrect trichomes with one-plane whorl of 8–12 free lateral rays and multiradiate trichomes with two or three whorls of 16–30 free lateral rays, in both trichomes lateral rays 0.15–0.7 mm long and central ray 0.15–0.25(–0.7) mm long. Leaves alternate, leaf blades (3–)4–8 times as long as petioles; stipules 0.5–0.8 × 0.15–0.3 mm, triangular, lanceolate or linear, with 4 sessile ovoid glands at base and/or one subglobose gland at apex, with stellate-porrect trichomes on both surfaces; petioles 0.4–1.7(– 2) cm long; leaf blades 2.2–8.9 × 1.2–4.7 cm, oval-elliptic, elliptic, ovate or oval-lanceolate, sometimes lanceolate or narrowly elliptic, membranaceous, base obtuse or rounded, sometimes slightly cordate or truncate with 4–6 patelliform nectary glands 0.2–0.7 mm diam., subsessile with stipe 0.1–0.2 mm long, at least two facing adaxial surface and other two facing abaxial surface; apex acute, obtuse, mucronate or apiculate, sometimes slightly emarginate or acuminate; margin entire or less commonly serrulate with globose sessile glands (colleters); venation brochidodromous with 4–8 pairs of secondary veins impressed on adaxial surface and slightly prominent on abaxial surface; discolorous, adaxial surface dark green with hirtellous indumentum of simple, 2–4-radiate or stellate-porrect trichomes, stellate-porrect trichomes with 6–11 lateral rays, sessile, lateral rays 0.2–0.5 mm long, porrect ray up to 1 mm long; abaxial surface light green with shortly tomentose indumentum of stellate-porrect trichomes with 6–8 lateral rays or multiradiate trichomes with 11–16 lateral rays, both sessile, lateral rays 0.2–0.7 mm long, central ray 0.2–0.8 mm long. Thyrses 2.8–16 cm long, peduncle 0.4–2.5 cm long, terminal, bisexual with 4–10 solitary pistillate flowers sparsely, rarely densely, distributed on ¼–½ of inflorescence axis, or thyrses unisexual staminate, less commonly unisexual pistillate; staminate cymules with 2–4 flowers, staminate flower bracts 0.4–1 × 0.4–0.7 mm, triangular, oval or oblong, margin entire, with 2 or 3 subglobose sessile glands at base, indumentum of stellate-porrect trichomes on external surface and hirsute indumentum of simple trichomes on margin, glabrous internally; 2 staminate flower bracteoles per cymule, 0.3–0.7 × 0.15–0.3 mm, triangular or ovate, with glands and indumentum similar to those of bracts; pistillate flower bracts 0.5–1(–2.2) × 0.3–0.8(–1) mm, triangular, margin entire, with ovoid or subglobose sessile glands, with sessile stellate-porrect trichomes externally, glabrous or glabrescent internally; 2 bracteoles per pistillate flower, 0.3–0.8 × 0.1–0.4 mm, linear or triangular, with subglobose glands at base. Staminate flowers 5–8 mm long; pedicels 1.6–4.7 mm long, glabrous, glabrescent, pubescent or tomentose; calyces 5(6)-partite, greenish with whitish indumentum, lobes 1.4–2 × 0.9–1.3 mm, ovate or largely ovate, united in ⅙–¼ of length, apex obtuse or acute, dorsal surface with shortly tomentose indumentum of 2 stellate-porrect sessile trichomes, villous at the apex, glabrous ventrally; petals 5(6), 2–2.9 × 0.6–1.2 mm, obovate or oblanceolate, apex rounded or obtuse, villous basally along margins at ⅓–½ of length; stamens 15–25(–27), 2.5–3.5 mm long, filaments 2–3 mm long, glabrous or villous only basally, anthers 0.5–0.7 × 0.4–0.7 mm, suborbicular or largely ellipsoid; nectary disks 5-segmented, segments transversely oblong, whitish, receptacle villous. Pistillate flowers 3.5–5.3 mm long, pedicels 0.8–1.5 mm long; sepals 5, 1–1.7 × 0.6–0.8 mm, equal, ovate or triangular, apex acute, margin entire, without glands, externally with pubescent or tomentose indumentum of stellate-porrect or multiradiate sessile trichomes, internally sparsely pubescent or glabrescent; petals globose 0.1–0.2 mm diam. or laminar 0.5–1.3 × 0.05–0.4 mm, linear or triangular, glabrous or with stellate trichomes externally; ovaries 1.2–1.4 × 1.3–1.8 mm, subglobose, with whitish tomentose indumentum of stellate-porrect shortly stipitate trichomes; styles 3, 2–3 mm long, united in ⅙–⅓ of length, then branching into 6 terminal tips, externally with glabrescent or pubescent indumentum of stellate trichomes basally; nectary disks 5-segmented or 5-lobed, segments or lobes transversely oblong, whitish. Capsules 5.7–6 mm diam., globose, greenish, pedicel 1.2–2.5(–4) mm long, columella with three flattened or slightly ascending tips
Exploring the Role of Topoisomerase II Beta in Macrophage Maturation and Pro-inflammatory Cytokine Production
No full textAlthough it is known that DNA topo IIβis required for the regulation of transcription during neural development and differentiation, it is not clear whether the enzyme is required during differentiation of human monocytes into macrophages and/or the subsequent transcription of
cytokine genes. To test this, a robust model of differentiation of monocyte-like cells into macrophage-like cells using U937 and HL-60 cells treated with phorbol 12-myristate 13-acetate (PMA) and Lipopolysaccharide (LPS) was validated. Differentiation was determined by morphological and growth characteristics and CD11b surface antigen expression as determined by flow cytometry. qRT-PCR was also used to measure mRNA transcript levels of key genes known to be up-regulated during monocyte differentiation and the secretion of pro-inflammatory cytokines produced by differentiated cells were measured using ELISA.
siRNA topo IIβknockdown did not hinder monocyte-like cells from undergoing differentiation, however experiments revealed a correlation between topo IIβknockdown and secreted TNFα, with the latter decreasing when topo IIβwas reduced. This pattern was also noted when measuring IL-1βsecretion. Similar results were seen using a Murine transgenic fibroblast cell line lacking topo IIβ, which when stimulated with LPS secreted significantly lower levels of IL-6 compared to the wild type cells. Thus topo IIβexpression is necessary for
secretion of normal levels of the cytokines, TNFα, IL-1βand IL-6 in response to LPS at certain time points. In addition in the macrophage-like state of the two cell lines, the relative levels of the βisoform (mRNA and protein) were shown to be significantly increased
compared to α, further outlining the importance of topo IIβin the differentiated state. Chromatin immuno-precipitation followed by qPCR showed however that topo IIβwas not associated at three defined proximal promoter regions of either the TNFαand IL-1βgenes, although further studies are required to rule out a direct association of topo IIβwith these and other regions of the genes.
Down regulation of topo IIβprotein using the inhibitor ICRF-193 did not hinder monocyte-like cells from undergoing differentiation either. However, contrary to the knockdown results, a 6 h pre-treatment with 1 nM ICRF-193 increased TNFαlevels in these cells, both at the
mRNA and the protein level, along with a slight increase in secreted TNFα. NF-κB, EGR2, TLR4 and TLR2 transcript levels were also increased under these conditions. Thus further studies are required to determine if these increases are due to additional cellular effects of the
drug or whether topo IIβmay play an inhibitory effect on transcription.
Thus it is clear that topo IIβplays an important role in expression of cytokines and understanding the exact nature of this requires further research that may yield potential new avenues for treatment of disease
The Back for Action Program for Increasing Everyday Activity Levels: Its Rationale, Design and Experimental Evaluation with People Over 70 Years of Age
No full textPopulation ageing and its impact on government provisions for healthcare has focused attention on the development of appropriate services and policies for older people. Considerable resources are being directed towards health promotion media campaigns which aim to encourage older people to initiate and maintain healthier and more active lifestyles. From a behaviour analytic (or ABA) perspective, improving the health and wellbeing of older people involves arranging supportive environments and applying self-management strategies for long-lasting behaviour change from sedentary to more active lifestyles. This important area of application of ABA principles has so far received surprisingly little attention from behaviour analysts.
This thesis describes the rationale, development and evaluation of the Back for Action Program (BAP), a comprehensive intervention based on ABA principles that aims to increase the everyday physical activities of older people. The main components of the BAP are described, including how it selects, measures and reinforces increased physical activity in people over 70 years of age. The first research study undertaken consisted of 7 single-case experiments that were designed to evaluate the effectiveness of the main components of the BAP: client feedback based on objective measures of daily activities, behavioural consultation including goal setting and problem solving, and self-management strategies for maintenance. The second research study consisted of a repeated measures group design evaluation involving arbitrary allocation of participants (n = 19) to either the BAP as a package or a ‘control’ condition. The effects of the BAP were evaluated using a comprehensive set of direct and collateral dependent measures of health and wellbeing. These covered participants’ physical, biochemical and psychological health and wellbeing. Research questions included whether the BAP leads to increases in daily activity and reduces sedentary behaviours, and whether higher levels of activity lead to improvements in measures of physical, biochemical, and psychological health and wellbeing. Results provided strong evidence in support of the BAP and showed that increasing daily activity levels by 20% to 103% had clinically significant health benefits even for this older group of people. In so doing, this thesis provides an overdue account of a comprehensive, effective behavioural approach to increasing ‘healthy ageing’ activities of free-living older people in the community
Pervasive gaps in Amazonian ecological research
No full textBiodiversity loss is one of the main challenges of our time,1,2 and attempts to address it require a clear un derstanding of how ecological communities respond to environmental change across time and space.3,4
While the increasing availability of global databases on ecological communities has advanced our knowledge
of biodiversity sensitivity to environmental changes,5–7 vast areas of the tropics remain understudied.8–11 In
the American tropics, Amazonia stands out as the world’s most diverse rainforest and the primary source of
Neotropical biodiversity,12 but it remains among the least known forests in America and is often underrepre sented in biodiversity databases.13–15 To worsen this situation, human-induced modifications16,17 may elim inate pieces of the Amazon’s biodiversity puzzle before we can use them to understand how ecological com munities are responding. To increase generalization and applicability of biodiversity knowledge,18,19 it is thus
crucial to reduce biases in ecological research, particularly in regions projected to face the most pronounced
environmental changes. We integrate ecological community metadata of 7,694 sampling sites for multiple or ganism groups in a machine learning model framework to map the research probability across the Brazilian
Amazonia, while identifying the region’s vulnerability to environmental change. 15%–18% of the most ne glected areas in ecological research are expected to experience severe climate or land use changes by
2050. This means that unless we take immediate action, we will not be able to establish their current status,
much less monitor how it is changing and what is being lostinfo:eu-repo/semantics/publishedVersio
