200,264 research outputs found

    Diversity of research for a sustainable challenging world: A compilation of research by Malaysian postgraduates in New Zealand.

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    Eleven papers in social sciences, science and technology by Malaysian postgraduate students from the University of Waikato, presented at the First Waikato Malaysian Postgraduate Colloquium 201

    Rahman, R

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    Música del mundo No. 48 Alem Qasimov - A.R. Rahman - Michael Nyman

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    El músico azerbaijano Alem Kassimov inicia esta emisión presentando el mugam, obra maestra del patrimonio oral e inmaterial de la humanidad, ofreciendo una selección titulada mugam bayati shiraz, en el segundo segmento se pueden escuchar obras del compositor indio A.R. Rahman, quien trabaja para la industria de Bollywood y aquí presenta obras del álbum Vande Mataram. Para finalizar, el gran compositod británico Michael Nyman ofrece una selección de obras de su álbum "Sangam"

    Current concepts on oxidative/carbonyl stress, inflammation and epigenetics in pathogenesis of chronic obstructive pulmonary disease

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    Chronic obstructive pulmonary disease (COPD) is a global health problem. The current therapies for COPD are poorly effective and the mainstays of pharmacotherapy are bronchodilators. A better understanding of the pathobiology of COPD is critical for the development of novel therapies. In the present review, we have discussed the roles of oxidative/aldehyde stress, inflammation/immunity, and chromatin remodeling in the pathogenesis of COPD. An imbalance of oxidants/antioxidants caused by cigarette smoke and other pollutants/biomass fuels plays an important role in the pathogenesis of COPD by regulating redox-sensitive transcription factors (e.g., NF-κB), autophagy and unfolded protein response leading to chronic lung inflammatory response. Cigarette smoke also activates canonical/alternative NF-κB pathways and their upstream kinases leading to sustained inflammatory response in lungs. Recently, epigenetic regulation has been shown to be critical for the development of COPD because the expression/activity of enzymes that regulate these epigenetic modifications have been reported to be abnormal in airways of COPD patients. Hence, the significant advances made in understanding the pathophysiology of COPD as described herein will identify novel therapeutic targets for intervention in COPD

    KONTRIBUSI A. R. RAHMAN DALAM MUSIK QAWWALI DI BOLLYWOOD INDIA TAHUN 2000-2021

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    Qawwali merupakan sebuah musik renungan sufi yang sudah ada sejak abad ke-13 di India. Qawwali tradisional tampil di Dargah (makam sufi) setiap malam kamis dan hari perayaan khusus lainnya. Setelah runtuhnya Mughal, para seniman Qawwali mulai mencari penghasilan di luar Dargah. Hingga pada tahun 1950-an Qawwali tampil dalam film Bollywood, namun tampil dalam lagu romansa. Kemudian di tahun 2000 A. R. Rahman mengangkat musik Qawwali bertema sufisme Dargah dan menginisiasi bentuk Qawwali ini tampil di Bollywood pada tahun setelahnya. Penelitian ini bermaksud meneliti bagaimanakah kontribusi A. R. Rahman dalam musik Qawwali di Bollywood. Berdasarkan uraian yang ada peneliti membagi dua pokok pembahasan, yaitu : 1). Apa itu musik Qawwali ? 2). Siapa A. R. Rahman ? 3). Apa kontribusi A. R. Rahman dalam musik Qawwali di Bollywood ?. Penelitian ini menggunakan pendekatan biografis, dan teori kontribusi dari Soerjono Soekanto, serta mengambil dua konsep: musik sufi dan pembaharuan. Metode yang digunakan dalam penelitian ini yaitu metode sejarah yaitu heuristik, interpretasi, verifikasi dan historiografi. Hasil penelitian menunjukkan musik Qawwali mulai diadopsi dalam perfilman Bollywood sejak tahun 1940-an dengan gaya sekulernya. Kemudian A. R. Rahman membuat perubahan baru pada penampilan Qawwali di film Bollywood, dengan menampilkan gaya Qawwali Dargah. Selain berkontribusi dalam menciptakan musik- musik Qawwali, Rahman juga sering membawa dan memperkenalkan Qawwali di setiap konsernya. Selain itu Rahman juga mendirikan sebuah perguruan tinggi musik, yang banyak mencetak generasi baru dalam dunia musik di India, termasuk musik Qawwali

    4° Sabîl-kouttâb d'Abd ar-Rahman Katkhoda

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    Bahgat Ali, Daressy Georges, Darke F. R. H., Haswell C. J. R., Patricolo Achille. 4° Sabîl-kouttâb d'Abd ar-Rahman Katkhoda. In: Comité de Conservation des Monuments de l'Art Arabe. Fascicule 32, exercice 1915-1919, 1922. p. 741

    Environmental toxicity, redox signaling and lung inflammation:the role of glutathione

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    Glutathione (gamma-glutamyl-cysteinyl-glycine, GSH) is the most abundant intracellular antioxidant thiol and is central to redox defense during oxidative stress. GSH metabolism is tightly regulated and has been implicated in redox signaling and also in protection against environmental oxidant-mediated injury. Changes in the ratio of the reduced and disulfide form (GSH/GSSG) can affect signaling pathways that participate in a broad array of physiological responses from cell proliferation, autophagy and apoptosis to gene expression that involve H(2)O(2) as a second messenger. Oxidative stress due to oxidant/antioxidant imbalance and also due to environmental oxidants is an important component during inflammation and respiratory diseases such as chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, acute respiratory distress syndrome, and asthma. It is known to activate multiple stress kinase pathways and redox-sensitive transcription factors such as Nrf2, NF-kappaB and AP-1, which differentially regulate the genes for pro-inflammatory cytokines as well as the protective antioxidant genes. Understanding the regulatory mechanisms for the induction of antioxidants, such as GSH, versus pro-inflammatory mediators at sites of oxidant-directed injuries may allow for the development of novel therapies which will allow pharmacological manipulation of GSH synthesis during inflammation and oxidative injury. This article features the current knowledge about the role of GSH in redox signaling, GSH biosynthesis and particularly the regulation of transcription factor Nrf2 by GSH and downstream signaling during oxidative stress and inflammation in various pulmonary diseases. We also discussed the current therapeutic clinical trials using GSH and other thiol compounds, such as N-acetyl-l-cysteine, fudosteine, carbocysteine, erdosteine in environment-induced airways disease

    R (on the application of Begum (By her litigation friend, Rahman)) v Headteacher, Governors of Denbigh High School [2006] UKHL 15, House of Lords

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    Essential Cases: Public Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in R (on the application of Begum (By her litigation friend, Rahman)) v Headteacher, Governors of Denbigh High School [2006] UKHL 15, House of Lords. The document also includes supporting commentary from author Thomas Webb.</p

    Appropriate Similarity Measures for Author Cocitation Analysis

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    We provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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