1,720,958 research outputs found
Subunit F modulates ATP binding and migration in the nucleotide-binding subunit B of the A 1A O ATP synthase of Methanosarcina mazei Gö1
Get PDF10.1007/s10863-012-9410-yJournal of Bioenergetics and Biomembranes441213-224JBBI
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
TAR-RNA recognition by a novel cyclic aminoglycoside analogue
Get PDFDie Bildung des Tat-Protein/TAR RNA-Komplexes ist ein entscheidender Schritt in der Regulation der Expression des HI-Virus (Human Immunodeficiency Virus, HIV). Für eine vollständige Transkription des viralen Gens ist die Interaktion des Tat/TARKomplexes mit dem positiven Transkriptionsfaktor-Komplex P-EFTb (Positive Transcription Elongation Factor) über dessen Cyclin T1-Komponente (CycT1) notwendig. Durch Mutagenesestudien wurde die Hexanukleotid-Schleife der TAR RNA als Kontaktstelle für die Wechselwirkung mit CycT1 identifiziert. Zur Entwicklung neuer Arzneimittel gegen das HIV stellt die Störung des Zusammenspiels zwischen dem Tat/CycT1-Komplex und der TAR RNA ein lohnendes Ziel dar. Positiv geladene Verbindungen wie Aminoglycoside oder Peptidmimetika binden an die TAR RNA und brechen so den Tat/TAR-Komplex auf. In dieser Arbeit wird die Bestimmung der dreidimensionalen Struktur des Komplexes zwischen der HIV-2 TAR RNA und einem Neooligoaminodeoxysaccharid mit Hilfe der NMR-Spektroskopie beschrieben. Im Gegensatz zu anderen Aminoglycosiden wechselwirkt diese neuartige Verbindung gleichzeitig mit den für die Bindung des Tat-Proteins verantwortlichen Resten des Bulges wie auch mit dem Adenosin 35 der Hexanukleotid-Schleife der TAR RNA. Diese Schleifenregion erfährt bei der Bildung des Komplexes mit dem Aminoglycosid eine große konformationelle Änderung. Dieser neue Bindungsmodus eröffnet zusammen mit der einfachen synthetischen Zugänglichkeit von Neooligoaminodeoxysaccharid-Derivaten die Möglichkeit, eine neue Klasse von TAR RNA bindenden Molekülen zu entwerfen. Diese könnten gleichzeitig die Bildung des binären Tat/TAR- wie auch des ternären Tat/TAR/CycT1-Komplexes durch Störung der Schleifen- und Bulge-Region der RNA verhindern.The formation of the Tat-protein/TAR RNA complex is a crucial step in the regulation of Human Immunodeficiency Virus (HIV)-gene expression. To obtain fulllength viral transcripts the Tat/TAR complex has to recruit the positive transcription elongation factor complex (P-EFTb), which interacts with TAR through its CyclinT1 (CycT1) component. Mutational studies identified the TAR hexanucleotide loop as a crucial region for contacting CyclinT1. Interfering with the interaction between the Tat/CycT1 complex and the TAR RNA is an attractive strategy for the design of anti- HIV drugs. Positively charged molecules, like aminoglycosides or peptidomimetics, bind the TAR RNA, disrupting the Tat/TAR complex. Here, we investigate the complex between the HIV-2 TAR RNA and a neooligoaminodeoxysaccharide by NMR spectroscopy. In contrast to other aminoglycosides, this novel aminoglycoside analogue contacts simultaneously the bulge residues required for Tat binding and the A35 residue of the hexanucleotide loop. Upon complex formation, the loop region undergoes profound conformational changes. The novel binding mode, together with the easy accessibility of derivatives for the neooligoaminodeoxysaccharide, could open the way to the design of a new class of TAR RNA binders, which simultaneously inhibit the formation of both the Tat/TAR binary complex and the Tat/TAR/CyclinT1 ternary complex by obstructing both the bulge and loop regions of the RNA
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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