192 research outputs found
Anti-Blanchard Macroeconomics. A comparative approach - with prefaces by Robert Skidelsky and Mauro Gallegati and an endorsement by Olivier Blanchard
No full textOlivier Blanchard, former chief economist of the IMF, is author of one of the most important standard macroeconomics textbooks which is used throughout the world. Endorsed by Blanchard himself, Anti-Blanchard Macroeconomics critically analyses prevailing economic theory and policy in comparison with alternative approaches. This textbook is designed to stand alongside Blanchard’s text, or indeed any other standard book on macroeconomics, but it can also be read independently. It provides undergraduate and advanced students with a critical view of the subject, and is also appropriate for scholars interested in a new way of analysing the debate between alternative schools of economic thought. Emiliano Brancaccio and Andrea Califano succinctly explore the relationship between theoretical models and economic policies, providing readers with examples and empirical exercises. The book highlights ways in which simple changes to the initial hypotheses of the dominant models can lead to alternative schemes that overturn the logical relationships and the policy prescriptions of standard macroeconomics
The role of molecular analyses in the diagnosis and treatment of non-small-cell lung carcinomas
No full textNon-small-cell lung cancer (NSCLC) subtyping has recently been a key factor in determining patient management with novel drugs. In addition, the identification of distinct oncogenic driver mutations frequently associated with NSCLC histotype and coupled to the clinical responses to targeted therapies have revolutionized the impact of histologic type and molecular biomarkers in lung cancer. Several molecular alterations involving different genes (EGFR, KRAS, ALK, BRAF, and HER2) seem to have a remarkable predilection for adenocarcinoma and specific inhibitors of EGFR and ALK are now available for patients with adenocarcinoma harboring the relevant gene alterations. The efficacy of histology-based and molecular-targeted therapies had a deep impact in (1) re-defining classification of lung cancer (particularly adenocarcinomas) and (2) routine clinical practice of pathologists involved in optimization of handling of tissue samples in order to guarantee NSCLC subtyping with the help of immunohistochemistry and adequately preserve tumor cells for molecular analysis. In agreement with the modern multidisciplinary approach to lung cancer, we reviewed here the diagnostic and predictive value of molecular biomarkers according to the clinical, pathologic, and molecular biologist viewpoints
Role of mesenchymal-epithelial transition amplification in resistance to anti-epidermal growth factor receptor agents
No full textAll patients with epidermal growth factor receptor (EGFR) mutant advanced non-small cell lung cancer (NSCLC) treated with an EGFR-tyrosine kinase inhibitor (EGFR-TKI) such as gefitinib, erlotinib or afatinib will progress after a median of 9-12 months. So far, development of a secondary T790M mutation represents the most common (approximately 60%) mechanism of resistance to these drugs. The relative rarity of mesenchymal-epithelial transition (MET) amplification in NSCLC suggests that this event plays a limited role in primary resistance to EGFR-TKI. In contrast, MET gene amplification has been detected as a secondary event representing one of the most relevant mechanisms involved in the acquired resistance to EGFR-TKIs both in preclinical and clinical studies. The aim of this review is to discuss the role of MET amplification as a mechanism of resistance to anti-EGFR therapies and to review strategies which aim at overcoming this mechanism of resistance, including studies assessing drug combinations targeting both EGFR and MET pathways
Late Onset Complications Secondary to Polyacrylamide Hydrogel-Based Filler for Rehabilitation of HIV-Related Facial Lipoatropy
No full textSurgical lip remodeling after injection of permanent filler
No full textBackground: A major concern regarding permanent lip fillers is difficulty with revision should this be required. Currently, the only way to treat lip sequelae is by surgical remodeling. Objectives: Based on the senior author's 6-year experience, the authors collectively suggest a surgical method to correct lip deformity in such situations. Methods: The records of 38 patients with lip deformity who underwent surgery between 2011 and 2017 after receiving permanent filler injections were analyzed retrospectively. A total of 38 consecutive patients (69 lips) with an average age of 38.8 years (range, 28-52 years) were treated surgically. Results: All patients experienced postoperative swelling (average duration, 15 days), and no infections were recorded. In 3 cases, a 1-cm dehiscence was documented, which healed by secondary intention. In 1 case, a hematoma noted several days after surgery resolved spontaneously within 3 weeks. In 2 upper lips, a minor touchup procedure (with the patient under local anesthesia) was performed 9 months after the initial surgery. Overall, patients noted that it took at least 6 to 9 months to achieve natural lip movement. The average time until softening of the lip tissue was 4 months. Conclusions: This study emphasizes the importance of informing patients that complete removal of permanent filler is not always possible. However, most of the authors' patients were pleased with the results. This study also highlights the importance of paying strict attention when approaching the area adjacent to the oral commissures in order to avoid potential reductions in mouth opening that can occur from postoperative scarring. Level of Evidence: 4:.Background: A major concern regarding permanent lip fillers is difficulty with revision should this be required. Currently, the only way to treat lip sequelae is by surgical remodeling. Objectives: Based on the senior author's 6-year experience, the authors collectively suggest a surgical method to correct lip deformity in such situations. Methods: The records of 38 patients with lip deformity who underwent surgery between 2011 and 2017 after receiving permanent filler injections were analyzed retrospectively. A total of 38 consecutive patients (69 lips) with an average age of 38.8 years (range, 28-52 years) were treated surgically. Results: All patients experienced postoperative swelling (average duration, 15 days), and no infections were recorded. In 3 cases, a 1-cm dehiscence was documented, which healed by secondary intention. In 1 case, a hematoma noted several days after surgery resolved spontaneously within 3 weeks. In 2 upper lips, a minor touchup procedure (with the patient under local anesthesia) was performed 9 months after the initial surgery. Overall, patients noted that it took at least 6 to 9 months to achieve natural lip movement. The average time until softening of the lip tissue was 4 months. Conclusions: This study emphasizes the importance of informing patients that complete removal of permanent filler is not always possible. However, most of the authors' patients were pleased with the results. This study also highlights the importance of paying strict attention when approaching the area adjacent to the oral commissures in order to avoid potential reductions in mouth opening that can occur from postoperative scarring. Level of Evidence: 4:
Experimental investigation of the fatigue crack growth behaviour in SLM additively manufactured 17-4 PH stainless steel specimens
No full textSelective Laser Melting (SLM) and, in general, the additive manufacturing technologies potentially offer numerous advantages to designers and technologists, such as the reduction of the lead-time of new products and the possibility of producing any kind of complex shape. The performance of components made by means of additive manufacturing under cyclic loading is influenced by crack orientation, porosities, residual stresses, heat treatments, corrosion environments etc. In particular, the crack orientation can influence the fatigue crack propagation. For this reason, in this paper, the fatigue crack propagation behaviour of 17-4 PH stainless steel made by SLM under different crack orientations is presented. The tests were carried out using 6.65 mm thick compact C(T) specimens tested at R = 0.1 and with a frequency of 5 Hz. The main objective was to study the effect of the crack orientation on crack-length vs. number of cycles curves
Fenomeno religioso, dati personali e tutela della dignità della persona
No full text[Religious phenomenon, personal data and individual dignity] The essay
explores the relation between religion, worship and freedom of conscience, on
one hand, and data protection, on the other. The Author focuses on two main
profiles. Firstly, the protection of information and data related to everyone’s
religious convictions and ideas, which GDPR defines as “special categories of
data”. Secondly, the Author deals with special categories of processors, such as
churches, religious organizations and religious associations (art. 91 GDPR). The
common aim is to guarantee human dignity and freedom, finding the balance
between religious freedom, privacy and a correct Church-State relationship
Il trattamento dei dati genetici: finalità di ricerca, esigenze di sicurezza e diritto alla protezione dei dati personali
No full text[Genetic data: scientific research purposes, security demands and the right to Data Protection] Given that genetic data belong to category of the “sensitive data”, this essay is focused on two constitutional issues, looking at the main national and European sources of law and the decisions of Italian Data Protection Authority. The Author, first, explores limits that the Data Protection Law imposes on the scientific research and healthcare purposes, especially referring to the Italian DPA General Authorizations. Secondly, she examines the difficult relation between Data Protection Law and public security purposes, focusing on the new National Genetic Database. The Author’s aim is to give some suggestions to single out guidelines for balancing individual liberties and public policy demands. Finally, she analyses the last initiatives to be adopted to complete the normative frame of the National Genetic Database
Videosorveglianza
No full textNelle moderne società, se le innovazioni tecnologiche rappresentano fattori di crescita del benessere e del miglioramento della qualità della vita, queste rischiano di incidere sui diritti inviolabili della persona; ciò nella misura in cui non si consideri con attenzione l’uso delle informazioni di carattere personale ottenute dalla elaborazione dei dati acquisiti e di un loro possibile conseguente utilizzo improprio. La progressiva espansione dei sistemi di videosorveglianza, installati in luoghi pubblici e privati, è un fenomeno ampiamente favorito dallo sviluppo di tecnologie nuove e sofisticate e pone dei quesiti proprio con riferimenti ai diritti della persona. Il contributo analizza la questione dal punto di vista costituzionalistico, per poi passare ad una panoramica della normativa in materia di videosorveglianza, alla giurisprudenza di merito e di legittimità e, infine, alle prassi del Garante per la protezione dei dati personali. Il contributo tiene conto della modifica normativa occorsa con il decreto legislativo n. 151 del 2015 che ha modificato le norme in materia di controllo a distanza dei lavoratori (art. 4 l. n. 300 del 1970)
Head bandage after otoplasty: How long should it be worn?
No full textOtoplasty is a surgical procedure often performed to
correct prominent ears, with the goal of normalizing their
shape and position. Various surgical techniques can be utilized
to create the antihelical fold if it is missing and/or to
reduce the conchal bowl if it is prominent. 1,2
Although postoperative dressings are clearly important
for successful outcomes following otoplastsy, 3–5 consensus is
lacking with respect to the optimal bandaging period. Opinions
on this subject vary greatly. Some experts advocate retaining
the bandage for 7–10 days, whereas others believe it
should be removed within 2 days. 1–5
The authors retrospectively analyzed the results of otoplasty
procedures performed by the senior author in
the last 10 years
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