912 research outputs found
A scalable infrastructure for teaching concepts of programming languages in Scala with WebLab: An experience report
No full textIn this paper, we report on our experience in teaching a course on concepts of programming languages at TU Delft based on Krishnamurthi's PAPL book with the definitional interpreter approach using Scala as meta-language and using the WebLab learning management system. In particular, we discuss our experience with encoding of definitional interpreters in Scala using case classes, pattern matching, and recursive functions; offering this material in the web-based learning management system WebLab; automated grading and feedback of interpreter submissions using unit tests; testing tests to force students to formulate tests, instead of just implementing interpreters; generation of tests based on a reference implementation to reduce the effort of producing unit tests; and the construction of a product line of interpreters in order to maximize reuse and consistency between reference implementations.Programming Language
Hematopoietic reconstitution dynamics of mobilized- and bone marrow-derived human hematopoietic stem cells after gene therapy
No full textMobilized peripheral blood is increasingly used instead of bone marrow as a source of autologous hematopoietic stem/progenitor cells for ex vivo gene therapy. Here, we present an unplanned exploratory analysis evaluating the hematopoietic reconstitution kinetics, engraftment and clonality in 13 pediatric Wiskott-Aldrich syndrome patients treated with autologous lentiviral-vector transduced hematopoietic stem/progenitor cells derived from mobilized peripheral blood (n=7), bone marrow (n=5) or the combination of the two sources (n=1). 8 out of 13 gene therapy patients were enrolled in an open-label, non-randomized, phase 1/2 clinical study(NCT01515462) and the remaining 5 patients were treated under expanded access programs. Although mobilized peripheral blood- and bone marrow- hematopoietic stem/progenitor cells display similar capability of being gene-corrected, maintaining the engineered grafts up to 3 years after gene therapy, mobilized peripheral blood-gene therapy group shows faster neutrophil and platelet recovery, higher number of engrafted clones and increased gene correction in the myeloid lineage which correlate with higher amount of primitive and myeloid progenitors contained in hematopoietic stem/progenitor cells derived from mobilized peripheral blood. In vitro differentiation and transplantation studies in mice confirm that primitive hematopoietic stem/progenitor cells from both sources have comparable engraftment and multilineage differentiation potential. Altogether, our analyses reveal that the differential behavior after gene therapy of hematopoietic stem/progenitor cells derived from either bone marrow or mobilized peripheral blood is mainly due to the distinct cell composition rather than functional differences of the infused cell products, providing new frames of references for clinical interpretation of hematopoietic stem/progenitor cell transplantation outcome.
Data supporting the current study are part of a registered clinical trial (NCT01515462). These data are available under restricted access for the sensitive nature of the clinical data, access can be obtained by request to the corresponding author (Prof. Alessandro Aiuti, San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), IRCCS San Raffaele Scientific Institute, Milan, 20132 Italy.). We intend to reply to any requests within two weeks and we will share the deposited data only for research purposes. The non-clinical data generated in this study are also provided as the Source Data file associated to the published work
ANALYSIS OF CATEGORY II PILOT-IN-THE-LOOP OSCILLATIONS BASED ON ROBUST STABILITY METHODS
No full textANALYSIS OF CATEGORY II PILOT-IN-THE-LOOP OSCILLATIONS BASED ON ROBUST STABILITY METHODS
No full textSanta Cristina ritrovata : Considerazioni preliminari sull’antica cappella del cimitero dell’Ospedale senese di Santa Maria della Scala
No full textAttraverso una disamina delle fonti documentarie e delle evidenze architettoniche, questo studio si propone di identificare l’ubicazione dell’antica cappella del cimitero di Santa Maria della Scala a Siena, decorata nel 1341 da Ambrogio Lorenzetti e associata al culto della martire Cristina a seguito della donazione all’Ospedale delle reliquie di Costantinopoli nel 1359. In particolare, si ipotizza che il sacello coincida in parte con un ambiente integrato nella sede della compagnia di Santa Caterina della Notte, in corrispondenza della zona dell’Ospedale che va sotto la denominazione di “magazzini della corticella”, visibile oggi in un allestimento tardo-ottocentesco
IPOTESI SULLA GROTTA DEL DRAGONE DI SCALA E INDAGINI PRELIMINARI
No full textA partire dall'analisi iconografica delle rappresentazioni zoologiche presenti nel mosaico pavimentale della Cattedrale di Otranto e da considerazioni topografiche e geografiche si ipotizza la presenza di reperti archeologici provenienti da Gerusalemme nella Grotta di Scala. Successive analisi GPR rilevano particolari compatibili con eventuali alterazioni del sottosuolo di origine antropica
Increased number and expertise of Italian respiratory high-dependency care units: The second national survey
No full textBACKGROUND:
The imbalance between the increasing prevalence of acutely decompensated respiratory diseases and the shortage of intensive care unit beds has stimulated the growth of respiratory high-dependence care units (RHDCUs).
METHODS:
We conducted a national survey to analyze the changes, in the past 10 years, in the number, structures, staff, procedures, diagnoses, and outcomes in Italian RHDCUs that satisfy the European Respiratory Society's criteria (modified according to the Italian Association of Hospital Pneumologists) for high level (respiratory intensive care unit), intermediate level (respiratory intermediate intensive care unit), and low level (respiratory monitoring unit) RHDCU care.
RESULTS:
The number of RHDCUs increased from 26 to 44. The relative prevalence among all the RHDCUs increased only for the low-level units (P = .03). Compared to 1997, in 2007 a higher percentage of Italian RHDCUs were located within respiratory wards than located outside of respiratory wards (P = .03), and the physician-to-patient mean ratio and the nurse-to-patient mean ratio per shift were lower (P = .001 and P = .002, respectively). Admissions for only monitoring decreased (P < .001), and admissions for active interventions increased: noninvasive ventilation (P = .002), invasive ventilation (P < .001), weaning from invasive ventilation (P < .001), and tracheal decannulation (P < .001). The complexity of RHDCU patients' conditions increased: there was a reduction in the percentage of COPD patients (P < .001) and an increase in the percentage of patients with neuromyopathies (P < .001) and de novo hypoxemia (P = .006).
CONCLUSIONS:
Between 1997 and 2007 there was an increase in the number and expertise of Italian RHDCUs, with a shift toward less expensive care, and greater complexity of interventions and patient dysfunctions. These findings support the crucial role of RHDCUs in the management of respiratory critical patients
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