6,134 research outputs found
Off‐label prescription of BNT162b2 mRNA COVID‐19 vaccine to <5‐year‐old children in the European Union
No full text‘Off-label’ or ‘unlicensed’ use of medicinal products are those that are prescribed outside the terms of their authorisation by the regulatory agency in a given jurisdiction (i.e. unapproved indication, age group, posology, route or schedule of administration). As the highly transmissible Omicron variant of SARS-CoV-2 becomes prevalent in the US, the EU and elsewhere, Pfizer/BioNTech announced that the results of the ongoing phase 2/3 trial (NCT04816643) assessing its BNT162b2 mRNA vaccine in 0.5–4-year-old children will be delayed to test a 3-dose regimen. A debate has emerged in the USA on whether this vaccine could be ethically prescribed to this age group of children. Whilst some commentators considered its prescription to be ethically acceptable in vulnerable kids at high risk of developing severe COVID-19,1, 2 recommendation against off-label paediatric use has been issued by the US Food and Drug Administration, American Academy of Paediatrics and Centers for Disease Control and Prevention. In addition, this latter has warned that off-label vaccine <5-year-old recipients may not be eligible for federal compensation in case of adverse events.1Peer reviewe
Musique espagnole de Piano / Rafael Arroyo pianiste
No full textTitre uniforme : [Aria, orgue, ré m]Titre uniforme : [Suite española. Piano. No 1. Op. 47]. ExtraitTitre uniforme : [Iberia]Comprend : Evocation / Isaac Albeniz - EL PUERTO / Isaac Albeniz - Fête Dieu à Séville : extraits d'Iberia / Isaac Albeniz - ASTURIAS : Prélude des Chants d'Espagne / Isaac Albeniz - ARIA : en ré mineur / Rafael Angles - Allegro de concert en Ut dièse majeur / Enrique Granados - Sonate en ré majeur / Mateo Albeniz - VIVA NAVARRA / Joaquin LarregiBnF-Partenariats, Collection sonore - BelieveContient une table des matière
La integridad científica y la comunicación selectiva de los resultados de los ensayos clínicos
No full textProposta de formaçâo docente na confecçâo de jogos geográficos: uma experiência com professores de campinas, Brasil
No full textArtigo produzido a partir de resultados preliminares da investigação de Doutorado intitulada “Alfabetização Cartográfica e o uso de Jogos na
Formação de Professores”, sob a orientação do Prof. Dr. Celso dal Ré Carneiro e Prof. Dr. Alfonso García de la Vega e co-orientação do Prof. Dr.
Rafael StraforiniO texto analisa qualitativamente uma experiência de Curso de Formação para professores do
Ensino Fundamental Municipal de Campinas (São Paulo/Brasil). O curso teve por objetivo a
construção e aplicação de Jogos Geográficos pelos professores participantes, com atividades
distribuídas em oito encontros. O registro foi feito pela pesquisadora com diários da
pesquisadora, questionários e gravações audiovisuais. Os procedimentos de análise foram
pautados na observação de três participantes que produziram relatos da experiência durante o
curso e na apreciação da aplicação do material. A análise se estendeu para a experiência de
parceria entre Universidade-Secretaria de Educação. Os resultados mais relevantes identificados
são: (a) o uso de jogos em sala de aula enfrenta dificuldades causadas pela insegurança quanto a
Cartografia e utilização de materiais que fogem da rotina da sala de aula; (b) a realização do
curso enfrentou excesso de burocraciaThe paper analyzes qualitatively one Training Course experience for teachers of Municipal
Elementary School of Campinas (São Paulo / Brazil). The course was aimed at construction and
application of Geographic Games by participating teachers with activities distributed in eight
meetings. The record was made by the researcher to researcher diaries, questionnaires and
audiovisual recordings. Screening procedures were based on the observation of three
participants who produced the experience reports during the course and the assessment of the
application of the material. The analysis is extended to the partnership experience between
University-Department of Education. The most relevant results are identified: (a) the use of
classroom games facing difficulties caused by uncertainty about the Cartography and use of
materials that are beyond the classroom routine; (B) the completion of the course faced
excessive bureaucracy
Symphonie n °2 en ré mineur op. 70 / A. Dvorak ; The Philharmonia Orchestra ; Rafael Kubelik, dir.
No full textTitre uniforme : Dvořák, Antonín (1841-1904). Compositeur. [Symphonies. No 7. B 141. Ré mineur]BnF-Partenariats, Collection sonore - BelieveContient une table des matière
Evolución de la edificación agraria en La Mancha. Materiales, diseño y tipologías
No full textEl presente trabajo trata sobre la evolución de las construcciones rurales en una de las mayores regiones españolas, La Mancha. Se analizan básicamente tres puntos: a) Los materiales y sistemas de ejecución. b) Los diseños. c) Como síntesis de las dos anteriores. Las tipologías. Los materiales se estudian por periodos de tiempo, y los diseños por tipo de edificación agraria. Se ha deducido que los edificios más interesantes por su evolución son las bodegas, harineras y almazaras. SUMMARY The present work deals on evolution suffered by rural buildings in one of the larger spanish región, La Mancha. Three different points have been analysed: a) Materials and carrying out systems. b) Designs. c) As a synthesis of the both above, typologys. Materials have been studied by periods of time, designs by type of rural buildings. It has been thought the most interesting buildings, in terms of evolution, are wineries, flour milis and olive-oil milis
Massekhet Keritot. Text, Translation and Commentary. A Feminist Commentary on the Babylonian Talmud
No full textThe tractate Keritot of the Babylonian Talmud belongs to the Order of Qodashim in the Mishnah. It discusses the Temple and its rituals, especially sacrifices, but deals mostly with laws of incest, sexual transgressions, childbirth, and miscarriages. In this commentary, Federico Dal Bo provides a historical, philological and philosophical investigation on these gender issues. He discusses almost the entire tractate, referring to many other sources, Jewish (the Dead Sea Scrolls, the Sifra, and other rabbinic texts) as well as non-Jewish (Akkadian, Hittite, and Ugaritic). The author also provides accurate philological observations both on the Mishnah and the Gemara. Finally, he addresses gender issues by combining a reductionistic approach to Talmudic study (the so called "Brisker method") with philosophical deconstruction. Dal Bo shows that in nearly the entire tractate Keritot the rabbis discuss human sexuality in a tendentious and restrictive way, claiming that heterosexuality is the only proper sexual contact and progressively stigmatizing any other kind of sexual behavior
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