62,296 research outputs found
Q&A: Peter Kimani, author of Dance of the Jakaranda, talks with Maëline Le Lay
No full textAfrica in Words. https://africainwords.com/2019/05/23/qa-peter-kimani-author-of-dance-of-the-jakaranda-talks-with-maeline-le-lay
Emerging role of multikinase inhibitors for refractory thyroid cancer
No full textCesar A Perez,1 Belisario A Arango,1 Michel Velez,1 Luis E Raez,2 Edgardo S Santos11University of Miami Miller School of Medicine/Sylvester Comprehensive Cancer Center, Miami, USA; 2Memorial Cancer Institute, Memorial Health Care System, Hollywood, FL, USAAbstract: Thyroid cancer incidence continues to increase, remaining the most common endocrine malignancy. The need for effective systemic therapies combined with high incidence of driver mutations and overexpression of molecular pathways make refractory thyroid cancer an ideal candidate for treatment with novel agents. Multikinase inhibitors have caused a paradigm shift in the treatment of patients with advanced iodine-refractory thyroid cancer. These agents have shown to be the most effective systemic therapy for this disease not only causing prolonged responses but also improving survival. The activity of these agents inhibiting several pathways simultaneously, such as rearranged during transfection protooncogene, mitogen-activated protein kinase, and angiogenesis, can probably explain the effectiveness in controlling the progression of this malignancy. Several of these agents are currently on clinical studies in patients with differentiated and medullary thyroid cancer and most of them are showing promising clinical activity. With the approval of vandetanib for the treatment of medullary thyroid cancer, a new era in the management of this disease has begun. The molecular rationale for the use of these drugs for thyroid cancer is discussed as well as their promising clinical results.Keywords: axitinib, cabozantinib, lenvatinib, mitogen-activated protein kinase (MAPK), motesanib, pazopanib, thyroid cancer, vandetanib, vascular endothelial growth factor receptor-2 (VEGFR2
Geographic profiling in Nazi Berlin: fact and fiction
No full textGeographic profiling uses the locations of connected crime sites to make inferences about the probable location of the offender’s ‘anchor point’ (usually a home, but sometimes a workplace). We show how the basic ideas of the method were used in a Gestapo investigation that formed the basis of a classic German novel about domestic resistance to the Nazis during the Second World War. We use modern techniques to re-analyse this case, and show that these successfully locate the Berlin home address of Otto and Elise Hampel, who had distributed hundreds of anti-Nazi postcards, after analysing just 34 of the 214 incidents that took place before their arrest. Our study provides the first empirical evidence to support the suggestion that analysis of minor terrorism-related acts such as graffiti and theft could be used to help locate terrorist bases before more serious incidents occur
Voyage dans le Levant. Par M. Le Comte de Forbin Paris, de l' Imprimerie Royale 1819.
No full textPreface.Dedication: by the author to sa majesté le roiPagination: PP8+132PVolumes: 1Text Genre:Pros
Norma Coverdale, B.A.: the treatment of women in selected works of Henry de Montherlant
No full textThe aim of this thesis is to determine how women are treated in selectedworks of Henry de Montherlant. This is explored by examining their relationshipswith other women as well as with men. Inevitably, this leads to an analysis ofthe multifaceted area of love. Part I researches Montherlant's prose work and included in this section is the investigation of the importance of 'l'ordre male' to the author and the influence this exerts over his early prose work in the areas of tauromachy, war and sport, and where the male adherence to this concept leaves women. The 'syncretisme et alternance' which is central to Montherlant's thinking is explored in this section.Part 2 is concerned with Montherlant's theatre in which the psychological development of the main characters is of great importance. It is in this section that a comparative study is made of the influence of Mme. Elisabeth Zehrfuss' written contribution to La Reine morte. Her unpublished notes are set out in full in the Appendix. The thesis also draws on the unpublished correspondence between Henry de Montherlant and Elisabeth Zehrfuss between the years 1934 and 1945. An investigation is made as to whether or not there are any differences between the way women are treated in Montherlant's prose and in his theatre and the conclusion is drawn that there are
An economic analysis of the production of hydrogen from wind-generated electricity for use in transport applications
No full textWind-generated electricity is often considered a particularly promising option for producing hydrogen from renewable energy sources. However, the economic performances of such systems generally remain unclear because of unspecified or favorable assumptions and operating conditions. The aim of this paper is to clarify these conditions by examining how the hydrogen produced is used. The analysis that has been conducted in the framework of the HyFrance 3 project concerns hydrogen for transport applications. Different technical systems are considered such as motorway hydrogen filling stations, Hythane®-fueled buses or second-generation biofuels production, which present contrasted hydrogen use characteristics. This analysis reveals considerable variations in hydrogen production costs depending on the demand profiles concerned, with the most favorable configurations being those in which storage systems are kept to a minimum.wind power ; hydrogen production
Rejet wallon du CETA, nouvel accroc pour le libre-échange
No full textAlors que les chefs d’État du Canada et des pays membres de l’Union européenne s’apprêtaient à se réunir à Bruxelles le 27 octobre prochain pour adopter le texte de l’Accord économique et commercial global (AECG, plus souvent désigné sous l’acronyme anglais CETA), deux parlements régionaux belges viennent d’y opposer leur veto. Cette décision suffira-t-elle à enterrer ce projet ? Rien n’est moins sûr. Une nouvelle étude présentée au Parlement de Wallonie affûte pourtant les arguments économiques des opposants en identifiant, chiffres à l’appui, ses uniques bénéficiaires : les investisseurs
Le Messager 60th Anniversary [Articles]
No full textFour photocopies of articles about the 60th anniversary of the French-language publication Le Messager, from the March 30, 1940, edition.
Article 1: \u27Notre 60ème anniversaire\u27, Le Messager, by Louis-Philippe Gagné
Article 2: \u27Notre 60ème anniversaire\u27, Le Messager, author unknown
Article 3: \u27Notre 60ème anniversaire\u27, Le Messager, by Louis-Philippe Gagné [duplicate]
Article 4: \u27Une contribution\u27, Le Messagerhttps://digitalcommons.usm.maine.edu/le-messager/1045/thumbnail.jp
Primary and metastatic brain cancer genomics and emerging biomarkers for immunomodulatory cancer treatment
No full textRecent studies with immunomodulatory agents targeting both cytotoxic T-lymphocyte protein 4 (CTLA4) and programmed cell death 1 (PD1)/programmed cell death ligand 1 (PDL1) have shown to be very effective in several cancers revealing an unexpected great activity in patients with both primary and metastatic brain tumors. Combining anti-CTLA4 and anti-PD1 agents as upfront systemic therapy has revealed to further increase the clinical benefit observed with single agent, even at cost of higher toxicity. Since the brain is an immunological specialized area it's crucial to establish the specific composition of the brain tumors' microenvironment in order to predict the potential activity of immunomodulatory agents. This review briefly summarizes the basis of the brain immunogenicity, providing the most updated clinical evidences in terms of immune-checkpoint inhibitors efficacy and toxicity in both primary and metastatic brain tumors with the final aim of defining potential biomarkers for immunomodulatory cancer treatment
Dr. Arthur Pindle, Spelman College, April, 2012
No full textThis video is a conversation with Dr. Arthur Pindle. Dr. Pindle talks about his book, "Bayou St. John". Daniel Le, AUC Woodruff Library, is the interviewer
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