60,930 research outputs found
Rae and the Tradition of Scottish Political Economy
No full textThe purpose of the chapter is to investigate how far Rae is representative of the Scottish Political Economy Tradition, where tradition is understood in terms of continuity in a shared approach, allowing for theoretical differences. While Rae conforms to most features identified with the Scottish tradition, his opposition to Smith’s methodology suggests a divergence of approach which would put him outside the tradition. It is argued here that this divergence applies only to Rae’s professed methodology, not to his practice
Funding of research in higher education: a panoptic view of the RAE
No full textThis thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.The thesis investigates the effects that the Research Assessment Exercise (RAE) has
on the Higher Education sector. The alternative view presented by the thesis is that
more knowledge can be created by concentrating on the different constituents of the
RAE and their specific interactions with particular areas of the Higher Education
sector. The RAE constituents are interpreted as drivers that influence and impact, in
dissimilar fashions, on different activities of Higher Education Institutions (HEI). This
micro analysis of the RAE enables the investigation to isolate the single effects of the
RAE drivers therefore creating a bottom-up analysis of the overall impact of the RAE.
The analysis of the impact that the drivers have on HEIs’ activities focuses on the
perception that individuals within the system have of the consequences of the RAE.
The focus on perceptions derives from personal observation of the lack of consensus
on the consequences that different drivers have on different areas. The use of
perceptions as the mean to assess the impact of the RAE enables the investigation to
create a picture of the consequences of the RAE that addresses behavioural change.
A multi-dimensional crystal view approach is used to accommodate both the micro
analysis and the perception assessment. The multi-dimensional crystal view, a
research contribution in its own right, is based on the principle that a micro analysis of
a complex system can be achieved by decomposing the system into a number of
dimensions. Insight is draw when the interactions between some of the dimensions are
investigated. In the specific case of the RAE the dimension are: the RAE drivers,
HEIs’ activities and points of observation (dimension that captures perceptions).
Knowledge and insight can be acquired when the interactions between the dimensions
are aggregated at successive higher levels. The supporting tool for the multidimensional
crystal view approach is a matrix that facilitates the analytical process.
The aggregation of the dimensions comes from combining textual statements from the
points of observation (perceptions) on the effects that the drivers of the RAE have on
the activities of HEIs. The highest level is a textual statement that synthesises all
lower level statements
Disruption of brainstem monoaminergic fibre tracts in multiple sclerosis as a putative mechanism for cognitive fatigue:a fixel-based analysis
No full textIn multiple sclerosis (MS), monoaminergic systems are altered as a result of both inflammation-dependent reduced synthesis and direct structural damage. Aberrant monoaminergic neurotransmission is increasingly considered a major contributor to fatigue pathophysiology. In this study, we aimed to compare the integrity of the monoaminergic white matter fibre tracts projecting from brainstem nuclei in a group of patients with MS (n = 68) and healthy controls (n = 34), and to investigate its association with fatigue. Fibre tracts integrity was assessed with the novel fixel-based analysis that simultaneously estimates axonal density, by means of 'fibre density', and white matter atrophy, by means of fibre 'cross section'. We focused on ventral tegmental area, locus coeruleus, and raphe nuclei as the main source of dopaminergic, noradrenergic, and serotoninergic fibres within the brainstem, respectively. Fourteen tracts of interest projecting from these brainstem nuclei were reconstructed using diffusion tractography, and compared by means of the product of fibre-density and cross-section (FDC). Finally, correlations of monoaminergic axonal damage with the modified fatigue impact scale scores were evaluated in MS. Fixel-based analysis revealed significant axonal damage - as measured by FDC reduction - within selective monoaminergic fibre-tracts projecting from brainstem nuclei in MS patients, in comparison to healthy controls; particularly within the dopaminergic-mesolimbic pathway, the noradrenergic-projections to prefrontal cortex, and serotoninergic-projections to cerebellum. Moreover, we observed significant correlations between severity of cognitive fatigue and axonal damage within the mesocorticolimbic tracts projecting from ventral tegmental area, as well as within the locus coeruleus projections to prefrontal cortex, suggesting a potential contribution of dopaminergic and noradrenergic pathways to central fatigue in MS. Our findings support the hypothesis that axonal damage along monoaminergic pathways contributes to the reduction/dysfunction of monoamines in MS and add new information on the mechanisms by which monoaminergic systems contribute to MS pathogenesis and fatigue. This supports the need for further research into monoamines as therapeutic targets aiming to combat and alleviate fatigue in MS.© 2021 T. Carandini, M. Mancini, I. Bogdan, C. Rae, A. Barritt, A. Sethi, N. Harrison, W. Rashid, E. Scarpini, D. Galimberti, M. Bozzali, M. Cercignani. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. See http://creativecommons.org/licenses/by/4.0/ </p
1ST MEASUREMENT OF GAMMA(D(S)(+)-]MU+NU)/GAMMA(D(S)(+)-]PHI-PI+)
No full textComplete Author List:
ACOSTA D, ATHANAS M, MASEK G, PAAR H, BEAN A, GRONBERG J, KUTSCHKE R, MENARY S, MORRISON RJ, NAKANISHI S, NELSON HN, NELSON TK, RICHMAN JD, RYD A, TAJIMA H, SCHMIDT D, SPERKA D, WITHERELL MS, PROCARIO M, YANG S, BALEST R, CHO K, DAOUDI M, FORD WT, JOHNSON DR, LINGEL K, LOHNER M, RANKIN P, SMITH JG, ALEXANDER JP, BEBEK C, BERKELMAN K, BESSON D, BROWDER TE, CASSEL DG, CHO HA, COFFMAN DM, DRELL PS, EHRLICH R, GALIK RS, GARCIASCIVERES M, GEISER B, GITTELMAN B, GRAY SW, HARTILL DL, HELTSLEY BK, JONES CD, JONES SL, KANDASWAMY J, KATAYAMA N, KIM PC, KREINICK DL, LUDWIG GS, MASUI J, MEVISSEN J, MISTRY NB, NG CR, NORDBERG E, OGG M, PATTERSON JR, PETERSON D, RILEY D, SALMAN S, SAPPER M, WORDEN H, WURTHWEIN F, AVERY P, FREYBERGER A, RODRIGUEZ J, STEPHENS R, YELTON J, CINABRO D, HENDERSON S, KINOSHITA K, LIU T, SAULNIER M, SHEN F, WILSON R, YAMAMOTO H, ONG B, SELEN M, SADOFF AJ, AMMAR R, BALL S, BARINGER P, COPPAGE D, COPTY N, DAVIS R, HANCOCK N, KELLY M, KWAK N, LAM H, KUBOTA Y, LATTERY M, NELSON JK, PATTON S, PERTICONE D, POLING R, SAVINOV V, SCHRENK S, WANG R, ALAM MS, KIM IJ, NEMATI B, ONEILL JJ, SEVERINI H, SUN CR, ZOELLER MM, CRAWFORD G, DAUBENMIER CM, FULTON R, FUJINO D, GAN KK, HONSCHEID K, KAGAN H, KASS R, LEE J, MALCHOW R, MORROW F, SKOVPEN Y, SUNG M, WHITE C, WHITMORE J, WILSON P, BUTLER F, FU X, KALBFLEISCH G, LAMBRECHT M, ROSS WR, SKUBIC P, SNOW J, WANG PL, WOOD M, BORTOLETTO D, BROWN DN, FAST J, MCILWAIN RL, MIAO T, MILLER DH, MODESITT M, SCHAFFNER SF, SHIBATA EI, SHIPSEY IPJ, WANG PN, BATTLE M, ERNST J, KROHA H, ROBERTS S, SPARKS K, THORNDIKE EH, WANG CH, DOMINICK J, SANGHERA S, SHELKOV V, SKWARNICKI T, STROYNOWSKI R, VOLOBOUEV I, ZADOROZHNY P, ARTUSO M, HE D, GOLDBERG M, HORWITZ N, KENNETT R, MONETI GC, MUHEIM F, MUKHIN Y, PLAYFER S, ROZEN Y, STONE S, THULASIDAS M, VASSEUR G, ZHU G, BARTELT J, CSORNA SE, EGYED Z, JAIN V, SHELDON P, AKERIB DS, BARISH B, CHADHA M, CHAN S, COWEN DF, EIGEN G, MILLER JS, OGRADY C, URHEIM J, WEINSTEIN A
Macroalgal biodiversity in the Beaufort Marine Biodiscovery Project
No full textAbstracts 48th European Marine Biology Symposium (Galway, 19-23 August 2013) - Poster number 1
D-1821: 210 South 100 East, Logan, Utah, Scott J. and Betty Rae Marshall/Clara M. Brown/Eva S. Bell/Ephriam and Rose T. Herzog residence. Lot 6 Block 11 Plat D
No full textD-1821: 210 South 100 East, Logan, Utah, Scott J. and Betty Rae Marshall/Clara M. Brown/Eva S. Bell/Ephriam and Rose T. Herzog residence. Lot 6 Block 11 Plat
Existence of laws with given marginals and specified support
No full textThesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Mathematics, 1982.MICROFICHE COPY AVAILABLE IN ARCHIVES AND SCIENCEBibliography: leaves 106-109.by Rae Michael Andrew Shortt.Ph.D
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