1,721,018 research outputs found
Простых решений не бывает
No full textЗасл. деятель науки РФ, член-корр. РАН, проф. В.Е. Радзинский о научном прогрессе и современных реалия
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Молекулярно-генетические детерминанты бесплодия при генитальном эндометриозе
No full textBackground: Genital endometriosis is an urgent problem of modern medicine. It is one of the hard-to-explain diseases and is the cause of reproductive health disorders, a decline in the quality of life and social disadaptation of women of any age. The aim of the study: To evaluate the relationship of genetic markers to the development of infertility in genital endometriosis. Materials and methods: The sample for the study included 428 patients with genital endometriosis: 132 patients with genital endometriosis accompanied by infertility (30.84%) and 296 patients with the onset of pregnancy (69.16%). Genotyping of 32 polymorphic loci of genes-candidates of hyperplastic diseases of the uterus was carried out. An analysis of the role of the polymorphic loci and their combinations in the formation of infertility in genital endometriosis was carried out using the APSampler software. Results: It was found that the risk factors for infertility in genital endometriosis are combinations of genetic variants T rs243865 MMP-2, 6A rs3025058 MMP-3, T rs11568819 MMP-7 and G rs17577 MMP-9 (OR = 2.08, pperm = 0.009), 2G rs1799750 MMP-1, 6A rs3025058 MMP-3 and G rs17577 MMP-9 (OR = 2.03, pperm = 0.013), T rs4073 IL-8, AA rs2107538 RANTES and A rs4512021 I-TAC (OR = 2.23, pperm = 0.009), T rs4073 IL-8, GA rs1801157 SDF1 and AA rs2107538 RANTES (OR = 2.80, pperm = 0.007), and the protective factors of risk of infertility in genital endometriosis combination of molecular genetic factors G rs1042838 PGR, C rs484389 PGR, T rs3798577 ESR1 and C rs2234693 ESR1 (OR = 0.44, pperm = 0.008), T rs699517 TYMS and AA rs1801394 MTRR (OR = 0.30, pperm = 0.022), A rs4073 IL-8 and G rs2107538 RANTES (OR = 0.33, pperm = 0.008). Conclusion: Polymorphism of candidate genes is associated with the development of infertility in genital endometriosis.Актуальность: Генитальный эндометриоз является актуальной проблемой современной медицины. Он входит в число труднообъяснимых заболеваний и является причиной нарушений репродуктивного здоровья, снижения качества жизни и социальной дезадаптации женщин любого возраста. Цель исследования: Оценка связей генетических маркеров с развитием бесплодия при генитальном эндометриозе. Материалы и методы: Выборка для исследования составила 428 пациенток с генитальным эндометриозом: 132 больных с генитальным эндометриозом сопровождающимся бесплодием (30.84%) и 296 больных с наступившей беременностью (69.16%). Проведено генотипирование 32 полиморфных локусов генов-кандидатов гиперпластических заболеваний матки. Анализ роли исследуемых полиморфных локусов и их комбинаций в формировании бесплодия при генитальном эндометриозе проведен с помощью программного обеспечения APSampler. Результаты: Установлено, что факторами риска формирования бесплодия при генитальном эндометриозе являются комбинации генетических вариантов Т rs243865 ММР-2, 6А rs3025058 ММР-3,Т rs 11568819 ММР-7 и G rs17577 ММР-9(OR= 2.08, ppem=0.009), 2G rs1799750 ММР-1, 6А rs3025058 ММР-3 и G rs17577 ММР-9 №= 2.03, pperm=0.013), Т rs4073 IL-8, АА rs2107538 RMIES и А rs4512021 I-ТАС (OR=2.23, pperm=0.009), Т rs4073 IL-8, GА rs1801157 SDF1 и АА rs2107538 RANTES (OR=2.80, pperm=0.007), а протективными факторами риска развития бесплодия при генитальном эндометриозе сочетания молекулярно-генетических факторов G rs1042838 РGR, С rs484389 РGR, Т rs3798577 ESR1 и С rs2234693 ESR1 (OR=0.44, pperm=0.008), Т rs699517 ТYМS и АА rs1801394 МТRR (OR=0.30, pperm=0.022), А rs4073 IL-8 и G rs2107538 RANTES (OR=0.33, pperm=0.008). Заключение: Полиморфизм генов-кандидатов ассоциирован с развитием бесплодия при генитальном эндометриозе
Treatment of climacteric disorders in menopause
No full textTreatment of climacteric disorders in menopause
Radzinsky V.E., Ordiyants I.M.
Peoples’ Friendship University of Russia, Moscow
The onset of menopause is one of the most critical periods in a woman’s life. Climacteric syndrome (CS) develops in 65-80% of women as a result of physiological deficiency of estrogens. The most frequent phenomena, associated with the age-related insufficiency of female sex hormones, include disorders from the autonomic nervous system, emotional disorders, atrophic changes in the vaginal wall, skin and mucous membranes, resulting in urogenital chronic inflammatory diseases, dermatitis. These disorders are the decisive factor in the prescription of drugs for CS treatment. The main direction of therapeutic and preventive work is a comprehensive correction of hormone-deficient conditions based on menopausal hormone therapy. However, this therapy can be contraindicative for women with various diseases, such as estrogen-dependent oncological diseases or thrombosis in the anamnesis. In this connection, the so-called «alternative» therapies (selective modulators
of estrogen receptors, phytoestrogens, neuropeptide vasomotor blockers) are used. The use of neuropeptide vasomotor blockers showed a confirmed positive effect in the treatment of clinical manifestations of CS. Pineamin®, created by synthesis of
a complex of epiphysis polypeptides, is one of such drugs. Pineamin® is a non – toxic drug, which quickly stops neurovegetative symptoms of CS.
Key words: climacteric syndrome, menopause, estrogen deficiency, phytoestrogens, neuropeptide vasomotor blockers, Pineamin.
For citation: Radzinsky V.E., Ordiyants I.M. Treatment of climacteric disorders in menopause // RMJ. 2018. № 5(I). P.37 –40.<br
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Occult form of premature ovarian insufficiency
No full textPremature ovarian insufficiency (POI) is a life-changing diagnosis, with profound physical and psychological consequences. Despite the description of different genetic, immune and iatrogenic factors of POI, the etiology of most cases of this disease are unexplained, and optimal management strategies are still unclear. Recent data showed that POI may have a long period of oligomenorrhea before the fully developed form (complete ovarian failure stage), with the occurrence of amenorrhea and climacteric symptoms. The main problem in the recognition of early stages of POI is the lack of proper diagnostic criteria. Patients with an undiagnosed occult form of POI may present with menstrual irregularities, unexplained infertility or repeated IVF failures. We evaluated 23 patients with unexplained oligomenorrhea and/or infertility. After a proper evaluation of these patients, a low ovarian reserve was identified, and an occult form of POI was diagnosed. © 2016 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group
Occult form of premature ovarian insufficiency
No full textPremature ovarian insufficiency (POI) is a life-changing diagnosis, with profound physical and psychological consequences. Despite the description of different genetic, immune and iatrogenic factors of POI, the etiology of most cases of this disease are unexplained, and optimal management strategies are still unclear. Recent data showed that POI may have a long period of oligomenorrhea before the fully developed form (complete ovarian failure stage), with the occurrence of amenorrhea and climacteric symptoms. The main problem in the recognition of early stages of POI is the lack of proper diagnostic criteria. Patients with an undiagnosed occult form of POI may present with menstrual irregularities, unexplained infertility or repeated IVF failures. We evaluated 23 patients with unexplained oligomenorrhea and/or infertility. After a proper evaluation of these patients, a low ovarian reserve was identified, and an occult form of POI was diagnosed. © 2016 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
- …
