1,721,163 research outputs found
Deciphering the genetic background of Systemic Sclerosis
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99157.pdf (Publisher’s version ) (Open Access)Radboud Universiteit Nijmegen, 09 oktober 2012Promotor : Riel, P.L.C.M. van Co-promotores : Coenen, M.J.H., Radstake, T.R.D.J
Oxygen shapes the early immune response
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207618.pdf (Publisher’s version ) (Open Access)Radboud University, 10 oktober 2019Promotores : Figdor, C.G., Radstake, T.R.D.J., Bogaart, G. van den Co-promotor : Marut, W
Gout. Diagnosis and its association with cardiovascular diseases
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183319.pdf (Publisher’s version ) (Open Access)Radboud University, 16 januari 2018Promotores : Riel, P.L.C.M. van, Radstake, T.R.D.J. Co-promotores : Janssen, M., Janssens, H.J.E.M
CCL 18 and CXCL 16: traffic control in rheumatoid arthritis.
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74402.pdf (Publisher’s version ) (Open Access)RU Radboud Universiteit Nijmegen, 09 april 2009Promotores : Riel, P.L.C.M. van, Adema, G.J. Co-promotor : Radstake, T.R.D.J.192 p
Innate Immunity in Rheumatoid and Psoriatic Arthritis. Toll-like Receptors as Mediators of Disease
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93619.pdf (Publisher’s version ) (Open Access)Radboud Universiteit Nijmegen, 15 juni 2012Promotor : Riel, P.L.C.M. van Co-promotor : Radstake, T.R.D.J.253 p
Marking the immune system in systemic sclerosis
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141096.pdf (Publisher’s version ) (Open Access)Radboud Universiteit Nijmegen, 03 juni 2015Promotores : Radstake, T.R.D.J., Berg, W.B. van den Co-promotores : Wagener, F.A.D.T.G., Vonk, M.C
Toll-like receptors in rheumatoid arthritis innate immune sensing of danger signals.
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52627.pdf (Publisher’s version ) (Open Access)RU Radboud Universiteit Nijmegen, 13 december 2007Promotores : Berg, W.B. van den, Riel, P.L.C.M. van Co-promotores : Radstake, T.R.D.J., Joosten, L.A.B.160 p
Hematopoietic stem cell-derived products for cancer immunotherapy
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187354.pdf (Publisher’s version ) (Open Access)Radboud University, 05 april 2018Promotores : Jansen, J.H., Radstake, T.R.D.J. Co-promotores : Dolstra, H., Hobo, W.A
A systems approach to unraveling progenitor potential and disease-associated immune cell networks.
No full textThe immune system plays a significant role in many immune and non-immune-mediated diseases' pathophysiology, it is imperative to holistically understand the many immune cell types, emphasizing their origin, function, and regulation. The origin of immune cells commences from the differentiation of the pluripotent hematopoietic stem cells (HSCs) via a process called hematopoiesis. The current literature describes hematopoiesis as a constantly occurring, step-wise lineage branching process, with each branching point signifying a commitment to a specific lineage. However, new data suggests that the classical HSC differentiation tree is more complex than known and suggests a paradigm shift depicting hematopoiesis. This thesis aims to address the unanswered questions about the immune cells and their progenitors. In the first part of this thesis, we dive deep into the ocean of immune cells and their progenitors – benchmarking their gene expression landscape. We then explore the relationship between the different cell types in the scope of their regulatory elements and further identify cell-specific genes and predict differentiation trajectories. In the second part of this thesis, we leverage the knowledge gained from the benchmarking and develop the requisite computational tools to identify immune cell types enriched in disease. We then apply our tool to several immune-mediated inflammatory diseases (IMIDs) and the highly infectious SARS-CoV-2 to shed light on COVID-19 disease in times of the growing pandemic
Letting go of the dichotomy between psoriasis and psoriatic arthritis
No full textPsoriasis and PsA have predominantly shared genetic background
and overlapping immunologic signature, confirming their denomination as falling
within a spectrum of one single disease. Local tissue factors induce a primary
inflammatory response, followed by a persistent inflammatory environment that
hosts innate and adaptive immune cells with overlapping functional effects. The
local inflammatory process of the tissue is capable of determining the phenotype:
where psoriasis and/or arthritis can occur in an independent fashion both from
clinical and pathophysiological point of view. In the circulating compartment we
detected only subtle changes between patients with psoriasis compared to PsA,
indicating that if cross-tissue contamination occurs, this is a chronic and subtle
process not readily detectible by cross-sectional screening. The result from the clinical work presented in this thesis indicate that screening questionnaires for PsA should be implemented in care for psoriasis patients attending dermatology clinics. Our results indicate major phenotypic manifestation should drive the choice of therapy, with methotrexate as preferred option over sulfasalazine for treating arthritis. Main phenotypic manifestations should drive study participant selection for both clinical and basic research questions, without the need to dichotomize PsA versus psoriasis. Future work should examine if the inflammatory response at the primary tissue site is capable of priming distant tissue sites for a secondary inflammatory response, in order to better understand and better treat PsA
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