1,723,103 research outputs found
The european public prosecuter's office
No full textvon Rabea Maria FabiAbweichender Titel laut Übersetzung der Verfasserin/des VerfassersDiplomarbeit Universität Innsbruck 202
Modern languages in Germany and Sweden : A Comparison of Subject Requirements for Modern Languages between Schleswig-Holstein and Sweden
No full textForeign languages are an important part of today's school system. At the beginning of the 2000s, the Common European Framework of Reference for Languages was introduced, which aims to create cross-country comparability of language qualifications.In order to find out whether the teaching content in the two countries has similarities, which ultimately lead to a similar level within the foreign language, I deal with the following ques- tions. On the one hand, What similarities and differences can be observed in the competence area of oral communication in the lower secondary level of foreign languages between Ger- many and Sweden? and on the other hand, What similarities and differences can be observed in the subject areas in the lower secondary level of foreign languages between Germany and Sweden? For this purpose, I conduct a comparative curriculum study and a curriculum analysis, examining the Swedish and Schleswig-Holstein curricula. It could be noted that there were several similarities and differences between the curricula of the two countries. Within the sub- ject areas, many overlapping topics could be identified, such as how to be able to introduce oneself in the target language and to be able to talk about the family. In terms of writing skills, there were similarities in terms of topics, but also in terms of the type of teaching, such as presentations and stories. The biggest differences could be found in the subject areas and in the competence of writing within the structure and scope. Thus, the Schleswig-Holstein curriculum is much more extensive and detailed than the Swedish curriculum
The european public prosecuter's office
No full textvon Rabea Maria FabiAbweichender Titel laut Übersetzung der Verfasserin/des VerfassersDiplomarbeit Universität Innsbruck 202
The european public prosecuter's office
No full textvon Rabea Maria FabiAbweichender Titel laut Übersetzung der Verfasserin/des VerfassersDiplomarbeit Universität Innsbruck 202
"Nun sag, wer ist mein Vater?" – Eine Besprechung der jüngsten Normierung des Auskunftsanspruchs des Spenderkindes nach einer Samenspende
No full textStem Cells in Cardiovascular Medicine: Historical Overview and Future Prospects
No full textCardiovascular diseases remain the leading cause of death in the developed world, accounting for more than 30% of all deaths. In a large proportion of these patients, acute myocardial infarction is usually the first manifestation, which might further progress to heart failure. In addition, the human heart displays a low regenerative capacity, leading to a loss of cardiomyocytes and persistent tissue scaring, which entails a morbid pathologic sequela. Novel therapeutic approaches are urgently needed. Stem cells, such as induced pluripotent stem cells or embryonic stem cells, exhibit great potential for cell-replacement therapy and an excellent tool for disease modeling, as well as pharmaceutical screening of novel drugs and their cardiac side effects. This review article covers not only the origin of stem cells but tries to summarize their translational potential, as well as potential risks and clinical translation
“Empowering” Cardiac Cells via Stem Cell Derived Mitochondrial Transplantation- Does Age Matter?
No full textWith cardiovascular diseases affecting millions of patients, new treatment strategies are urgently needed. The use of stem cell based approaches has been investigated during the last decades and promising effects have been achieved. However, the beneficial effect of stem cells has been found to being partly due to paracrine functions by alterations of their microenvironment and so an interesting field of research, the “stem- less” approaches has emerged over the last years using or altering the microenvironment, for example, via deletion of senescent cells, application of micro RNAs or by modifying the cellular energy metabolism via targeting mitochondria. Using autologous muscle-derived mitochondria for transplantations into the affected tissues has resulted in promising reports of improvements of cardiac functions in vitro and in vivo. However, since the targeted treatment group represents mainly elderly or otherwise sick patients, it is unclear whether and to what extent autologous mitochondria would exert their beneficial effects in these cases. Stem cells might represent better sources for mitochondria and could enhance the effect of mitochondrial transplantations. Therefore in this review we aim to provide an overview on aging effects of stem cells and mitochondria which might be important for mitochondrial transplantation and to give an overview on the current state in this field together with considerations worthwhile for further investigations
Research('s) Sweet Hearts: Experimental Biomedical Models of Diabetic Cardiomyopathy
No full textDiabetes and the often accompanying cardiovascular diseases including cardiomyopathy represent a complex disease, that is reluctant to reveal the molecular mechanisms and underlying cellular responses. Current research projects on diabetic cardiomyopathy are predominantly based on animal models, in which there are not only obvious advantages, such as genetics that can be traced over generations and the directly measurable influence of dietary types, but also not despisable disadvantages. Thus, many studies are built up on transgenic rodent models, which are partly comparable to symptoms in humans due to their genetic alterations, but on the other hand are also under discussion regarding their clinical relevance in the translation of biomedical therapeutic approaches. Furthermore, a focus on transgenic rodent models ignores spontaneously occurring diabetes in larger mammals (such as dogs or pigs), which represent with their anatomical similarity to humans regarding their cardiovascular situation appealing models for testing translational approaches. With this in mind, we aim to shed light on the currently most popular animal models for diabetic cardiomyopathy and, by weighing the advantages and disadvantages, provide decision support for future animal experimental work in the field, hence advancing the biomedical translation of promising approaches into clinical application
A coupled far-field formulation for time-periodic numerical problems in fluid dynamics
No full textConsider uniform flow past an oscillating body generating a time-periodic motion in an exterior domain, modelled by a numerical fluid dynamics solver in the near field around the body. A far-field formulation, based on the Oseen equations, is presented for coupling onto this domain thereby enabling the whole space to be modelled. In particular, examples for formulations by boundary elements and infinite elements are described
iPSCs and Exosomes: Partners in Crime Fighting Cardiovascular Diseases
No full textCardiovascular diseases are the leading cause of mortality worldwide. Understanding the mechanisms at the basis of these diseases is necessary in order to generate therapeutic approaches. Recently, cardiac tissue engineering and induced pluripotent stem cell (iPSC) reprogramming has led to a skyrocketing number of publications describing cardiovascular regeneration as a promising option for cardiovascular disease treatment. Generation of artificial tissue and organoids derived from induced pluripotent stem cells is in the pipeline for regenerative medicine. The present review summarizes the multiple approaches of heart regeneration with a special focus on iPSC application. In particular, we describe the strength of iPSCs as a tool to study the molecular mechanisms driving cardiovascular pathologies, as well as their potential in drug discovery. Moreover, we will describe some insights into novel discoveries of how stem-cell-secreted biomolecules, such as exosomes, could affect cardiac regeneration, and how the fine tuning of the immune system could be a revolutionary tool in the modulation of heart regeneration
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