1,720,995 research outputs found
Correlation between phenotypic and proteomic variability in Thlaspi caerulescens population adapted to serpentine Ni rich soil of Monte Prinzera.
No full textIdentification of analytical and molecular descriptors for heavy metals decontamination in poplar species: genomic approach
No full textIdentification of analytical and molecular descriptors for heavy metals decontamination in poplar species: a genomic approach.
No full textGenomic and proteomic approach to identify analytical and molecular descriptors for Cd decontamination in poplar species.
No full textIdentification of molecular descriptors for heavy metals decontamination in poplar species.
No full textOptimizing Formulation Conditions of PLGA Microparticles to Enhance Indomethacin Encapsulation
Full text linkDrug delivery systems can avoid the drawbacks of Indomethacin (IND), a non-steroidal anti-inflammatory drug used to treat osteoarthritis and arthritis, which requires high doses to reach therapeutic plasma levels leading to significant systemic side effects. This study aims to optimize poly(lactic-co-glycolic acid) (PLGA) microparticles (MPs) for intra-articular IND administration. MPs are prepared by solvent evaporation and freeze-dried for stability. Initial formulations with Tween 80 yield rubbery samples with low drug loading (1%); replacement of Tween 80 with Gelatin produces a stable powder with syringable MPs (particles size: 7 mu m), although, DL (3%) and EE (30%) remain suboptimal, due to IND polymorphic transformation. Differential Scanning Calorimetry and Fourier-Transform Infrared spectroscopy demonstrate a molecular dispersion of IND in PLGA. Adjusting the aqueous phase to pH 3 in the formulation process, i.e below IND pKa, significantly enhances EE (90%) due to the reduction of drug solubility in the external aqueous phase. In vitro release study shows prolonged IND release over several days, confirming an effective drug encapsulation. This study provides a foundational framework toward the optimization of the successful encapsulation of IND in PLGA MPs, potentially advancing future clinical applications of such drug delivery systems.This study aims to optimize PLGA microparticles for intra-articular delivery of Indomethacin (IND). The use of Gelatin as a surfactant in place of Tween 80 limited the plasticizer effect on the polymer, improving stability. Adjusting pH to 3 in the external phase enhanced encapsulation efficiency (90%), leading to prolonged IND release, demonstrating effective drug encapsulation for potential clinical use. imag
Analisi proteomica della risposta al nichel nella specie iperaccumulatrice Thlaspi caerulescens.
No full textAnalisi proteomica comparativa nel clone “Poli” di Populus nigra L. per determinare e valutare i fenomeni di tolleranza e uptake durante stress da cadmio.
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