1,721,025 research outputs found
Pick-herxheimer's acrodermatitis chronica atrophicans in an endemic area of northern italy
No full textA Practical Approach to the Diagnosis of Lyme Borreliosis: From Clinical Heterogeneity to Laboratory Methods
Full text linkClinical evaluation of Lyme Borreliosis (LB) is the starting point for its diagnosis. The patient’s medical history and clinical symptoms are fundamental for the disease recognition. The heterogeneity in clinical manifestations of LB can be related to different causes, including the different strains of Borrelia, the possible co-infection with other tick transmitted pathogens and also the interactions with the human host. This review aims at describing the heterogeneous symptoms of Lyme Borreliosis as well as a practical approach for the disease recognition, both in terms of clinical features and diagnostic/research tools
Neurological manifestations of Tick-borne encephalitis in North-Eastern Italy
No full textTick-borne encephalitis (TBE) is an infectious zoonotic disease, moving from Central Europe to other countries and still rare in Italy. The disease, produced by the European subtype virus, typically takes a biphasic course with neurological disorders of different severity during its second phase. We report the first three TBE cases in Friuli Venezia Giulia (FVG), characterised by extremely variable clinical features. Knowledge of these different presentations will assist physicians in increasing their level of attention to TBE also in this region, where no cases of TBE had been reported in the past, despite the fact that it borders countries with high prevalence of the infection
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
The total testing process of intra-operative parathyroid hormone. A narrative review
No full textBackground: Primary hyperparathyroidism (pHPT) is a common endocrine disorder, due to an excessive secretion of parathyroid hormone (PTH) from one or more parathyroid gland(s), where the only cure remains surgery. The surgical approach has become less invasive over the years, thanks to the advances in the preoperative localization of the enlarged parathyroid gland, as well as to the possibility to measure intra-operative parathyroid hormone (IOPTH). After the targeted removal of a parathyroid gland, IOPTH can confirm biochemically the cure of pHPT, such that it helps the surgeon to judge if the parathyroidectomy has been successful and there is no need of additional dissection. As with all laboratory tests, the quality of IOPTH total testing process is essential to the best utilization of patients' results. However, this can be affected by errors occurring in different phases. This review aims to describe the total testing process of IOPTH. Methods: We performed a search in Pubmed and a review of the literature on the current management of pHPT and the total testing process of IOPTH measurement. Results: Compared to previous studies focusing on single aspects of the IOPTH testing process, here we have analyzed all the steps crucial for the quality of IOPTH from the “pre-pre” to the “post-post” analytical phase. Conclusions: Clinicians and laboratory scientists should be aware of all the potential sources of errors in IOPTH measurement in order to improve their daily management of pHPT
ST2 marker might help to stratify in-hospital high risk patients with Tako-tsubo cardiomyopathy
No full textBorrelial Diseases Across Eurasia
Full text linkThis comprehensive review explores the distribution, diversity, and epidemiology of tick-borne borrelioses across Eurasia, focusing on Lyme borreliosis (LB) and other Borrelia-related infections. The genus Borrelia is categorized into three major groups, the Lyme Group (LG), the Relapsing Fever Group (RFG), and the Echidna-Reptile Group (REPG), each with distinct vectors, reservoirs, and pathogenic profiles. LB, caused by Borrelia burgdorferi sensu lato, is highly endemic in Europe and is increasingly reported in Asia, although it is underdiagnosed in Southeast Asia due to limited surveillance. This review details the ecological dynamics of tick vectors-primarily Ixodes spp.-and their vertebrate hosts, emphasizing the role of migratory birds and climate change in disease spread. It also highlights the presence of relapsing fever Borrelia species transmitted by soft ticks (Ornithodoros spp.) and the emergence of novel species such as Borrelia miyamotoi (RFG) and Borrelia turcica (REPG). This study underscores the need for harmonized surveillance systems, improved diagnostic tools, and integrated public health strategies to address the growing threat of borreliosis in Eurasia
ST2 marker might help to stratify in-hospital high risk patients with Tako-tsubo cardiomyopathy
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