972 research outputs found
Characterization of a wilty sunflower (Helianthus annuus L.) mutant III. Phenotypic interaction in reciprocal graft from wilty mutant and wild type plants
No full textGenetic analysis of an electrophoretic variant for the chloroplast-associated form of Cu/Zn superoxide dismutase in sunflower (Helianthus annuus L.)
No full textPolyacrylamide gel electrophoresis of water-soluble proteins from sunflower (Helianthus annuus L.) cotyledons, followed by specific staining for superoxide dismutase activity, discriminated, according to their electrophoretic mobility, two distinct achromatic bands for Cu/Zn superoxide dismutase. Zymograms of proteins from isolated chloroplasts showed that the chloroplast-located Cu/Zn superoxide dismutase (Cu/ZnSODchl) migrated faster in the SOD activity-stained gels. An electrophoretic variant pattern, whose mobility is lower than the control pattern, was identified in the ABA-deficient mutant w-1. The variant is coded by a nuclear gene with two codominant alleles
Control of hybrid ship drive systems
No full textStricter regulations on emissions force ship owners and designers to come up with new solutions for ship propulsion systems. Hybrid drive systems consisting of prime movers and batteries, like in the Toyota Prius, show great potential, especially in special ships like harbour tugs. Economic and environmental performance of such systems strongly depends on the way it is controlled. Dynamic computer models of system components were built to compare different system lay-outs and different control strategies and thus support the ship system designer with design decisions. A combination of fuzzy rule-based and optimization-algorithm control offer the best results. The modeling method, the different simulations, the optimization methods and resulting consequences for the ship system design are the main topics of this paper.Accepted Author ManuscriptShip Design, Production and Operation
Bibliographie : Octavia römische Geschichte, [vol. 1] (Nürnberg: J. Hoffmann, 1677)
No full textZur "Römischen Octavia" sind in der Herzog August Bibliothek (23:) und im Staatsarchiv (SA) Wolfenbüttel umfangreiche Vorarbeiten, Manuskripte und Diktatniederschriften erhalten, was für einen Roman des 17. und frühen 18. Jahrhunderts eine absolute Seltenheit darstellt. Über die gedruckten Bände hinaus existieren auch noch große Teile der Diktatniederschriften für einen abschließenden achten Band des Romans. Am verlässlichsten informiert hierüber die Einleitung zur Historisch-kritischen Ausgabe in HKA I, pp. XIX-LIX. Zur umfangreichen erhaltenen Korrespondenz Anton Ulrichs vgl. Mazingue (1978), pp. 887-900. Der Roman erschien in zwei Fassungen - Fassung A, verlegt in Nürnberg, und Fassung B, verlegt in Braunschweig und Wien, weichen im Text voneinander ab. A war zuerst auf vier Bände konzipiert, ist dann aber auf sechs Bände erweitert worden. Diese sechs Bände wurden 1711 zu einer Werkausgabe gruppiert. Fassung B war zuerst ebenfalls auf sechs, später auf acht Bände konzipiert, von ihr erschienen sechs Bände in Braunschweig zwischen 1712 und 1714 und ein siebter in Wien 1762. Von den Ausgaben A.3.a, A.1.b, A.2.b sind Druckvarianten überliefert, die jeweils nach den Nachdrucken der ersten drei Bände (1685-1702) und vor 1711 entstanden sind. Die ersten drei Bände der Ausgabe von 1711 bieten zum weit überwiegenden Teil Material dieser Druckvarianten
Targeted therapy with trastuzumab in dysplasia and adenocarcinoma arising in Barrett’s esophagus: a traslational approach
No full textBibliographie : Octavia römische Geschichte. Zugabe des ersten Theils, [vol. 2] (Nürnberg: J. Hoffmann, 1678)
No full textZweiter Band der ersten Fassung der "Römischen Octavia". Cf. zur vollständigen Publikationsgeschichte: Octavia römische Geschichte, [vol. 1] (Nürnberg: J. Hoffmann, 1677). Enthält mehrere teils wahrscheinlich, teils sicher autorfremde Gedichte. Zwei davon stammen von Christian Hofmann von Hofmannswaldau (vgl. HKA I, pp. CLXXIVf., Anm. 195). Von der "Geschichte der Flavia Domitilla und der Cönis", pp. 920-1015, existiert eine Übersetzung einer unbekannten französischen Hofdame ins Französische, datiert auf den 9. März 1714 (23: Cod.Guelf. 196.1 Extravag.)
Bevacizumab in Clinical Practice: Prescribing Appropriateness Relative to National Indications and Safety
No full textThe aim of this study was to describe the clinical use of bevacizumab in Lombardy (9.5 million inhabitants), Italy, during 2006-2007 in patients with metastatic colorectal cancer (mCRC) to evaluate compliance with the Italian Medicine Agency (AIFA) indications, the incidence of adverse events, and the survival rate. We performed computerized record linkage among three different Lombardy health care databases: File F registry, Regional discharge database, and Registry Office records. Patients were classified into approved and off-label uses according to the AIFA indications. Treatment with bevacizumab was administered to 780 patients, of whom 81.7% (n = 637) had mCRC. Among these, 37.8% (n = 241) of patients received the drug in observance of AIFA indications. Overall, similar to 10% of patients had serious treatment-related toxicities (fistula, 3.5%; venous thromboembolism, 2.8%; hemorrhage, 1.9%; intestinal perforation and arterial thromboembolism, <1%). The 1-year survival rate was 74.3% and the 2-year survival rate was 39.2%. The median survival time was 20.5 months, and there were no meaningful differences between gender and age groups. There was a gap between the bevacizumab approved indication and clinical practice pattern: overall, less than one half of the patients received bevacizumab in observance with the regulatory indication. The main reason for nonadherence to the indication was use as a second-line or advanced line of therapy. The incidence of serious adverse events and the survival rates of mCRC patients were similar to those reported in clinical trials. The Oncologist 2012; 17: 117-12
CXCR4, EGFR and HER2 expression in patients with high-risk synovial sarcoma (SS): A clinicopathologic study
No full textPlasma cytokines profile in older subjects with late onset Alzheimer's disease or vascular dementia.
No full textSome cytokines have been involved in the pathogenesis of late onset Alzheimer's disease (LOAD). A possible increase in plasma cytokines levels has been reported in LOAD and vascular dementia (VD), but the results of previous studies are conflicting. We evaluated the plasma levels of IL-6, TNF-alpha, IL-1beta, and IL-10 in four groups of older individuals: 60 patients with LOAD, 80 patients with VD, 40 subjects with cerebrovascular disease but without dementia (CDND), and 42 controls (C). By analysis of covariance (adjustment for age, gender, coronary heart disease, diabetes, hypertension, smoking, and alcohol consumption) we found that: *IL-1beta was higher in VD, LOAD, and CDND compared with controls (p<0.005). *TNF-alpha was higher in VD and LOAD compared to C (p<0.05), and in VD compared to LOAD (p<0.03). *IL-6 was higher in VD compared with LOAD (p<0.03). No differences in IL-10 values were found (Kruskal-Wallis, Asymp. Sig. 0.14). By logistic regression analysis, we demonstrated that high levels (defined as above the median) of IL-1beta and TNF-alpha, but not of IL-6, were associated with increased likelihood of having VD and LOAD compared to C, while high IL-6 levels were associated with a increased probability of having VD, compared with LOAD. Our study support the notion of a low-grade systemic inflammation in older patients with LOAD or VD, characterized by an increase in plasma IL-1beta and TNF-alpha levels. The high IL-6 levels found in VD might be not a specific finding, as it might come from several conditions including atherosclerosis and related vascular risk factors, comorbidity, and frailty
The effects of business ethics and corporate social responsibility on intellectual capital voluntary disclosure
No full textPurpose – This study aims to examine the potential effect that business ethics (BE) in general and corporate
social responsibility (CSR) more specifically can exert on the voluntary disclosure (VD) of intellectual capital
(IC) for the ethically most engaged firms in the world.
Design/methodology/approach – The research design is based on an inductive approach. As part of the
global quantitative investigation, the authors have analyzed the impact of BE and CSR on the transparent
communication of the IC. The data under analysis have been investigated using multiple linear regression.
Findings – Based on a sample of 83 enterprises emerging as the most ethical companies in the world, the
results have revealed that the adoption of ethical and socially responsible approach is positively associated
with the extent of VD about IC. This finding may help attenuating the asymmetry of information and the
conflict of interest potentially arising with corporate partners. Hence, IC-VD may stand as an evidence of ethical
and socially responsible behaviors.
Practical implications – Global and national regulators and policymakers can be involved by these results
when setting social reporting standards because they suggest that institutional and/or cultural factors affect
top management’s social reporting behavior in the publication of the IC information.
Social implications – Direct and indirect stakeholders, if supported by ethical and socially responsible
behaviors of the company, could assess more in detail the quality of the disclosed information concerning
the IC
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