1,721,154 research outputs found
Involvement of genes and non-coding RNAs in cancer: profiling using microarrays
No full textMicroRNAs (miRNAs) are small noncoding RNAs (ncRNAs, RNAs that do not code for
proteins) that regulate the expression of target genes. MiRNAs can act as tumor suppressor
genes or oncogenes in human cancers. Moreover, a large fraction of genomic ultraconserved
regions (UCRs) encode a particular set of ncRNAs whose expression is altered in human
cancers. Bioinformatics studies are emerging as important tools to identify associations
between miRNAs/ncRNAs and CAGRs (Cancer Associated Genomic Regions). ncRNA
profiling, the use of highly parallel devices like microarrays for expression, public resources
like mapping, expression, functional databases, and prediction algorithms have allowed the
identification of specific signatures associated with diagnosis, prognosis and response to
treatment of human tumors
Stato costituzionale (da I a V)
No full textAspetti fondamentali dello Stato costituzionale e della sua evoluzione storic
IAQ e inquinamento urbano: proposte operative per la definizione di nuovi sitemi impiantistici per la climatizzazione ambientale
No full textIndoor air quality in residential buildings: costs, effects and benefits of mechanical ventilation systems
No full text
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Reimagining urban destinations: Adaptive and transformative city brand attributes and values in the pandemic crisis
No full textThis paper contributes to the post-Covid urban tourism debate. It focuses on how cities respond to the pandemic asking how and to what extent urban destination brands are leverged by city marketers for coping with the Covid-19 crisis. It explores city brand values and attributes change as a component of the urban approach to facing the current crisis. Content analysis is carried out on pre- and post-pandemic brand communication of four Italian iconic cultural destinations (Rome, Florence, Venice and Milan) on Instagram. Findings suggest adaptive and transformative brand responses to the pandemic crisis, projecting the cities into future development scenarios. This research contributes to the recovery versus reform debate on post-Covid urban contexts and opens research on the pandemic effects on values, images and tourism stakeholders' mindsets and brand experimentation on social media platforms
Bevacizumab eye drop treatment stimulates tear secretion in rats through changes in VEGF and NGF lacrimal gland levels
No full textVEGF and NGF are known to modulate corneal healing, neovascularisation and tear secretion. While a VEGF-NGF cross talk has been recently shown to modulate corneal healing in rats, it is not known whether it also plays a role in the regulation of lacrimal function. In this study we aim to investigate the effects of anti-VEGF eye drop treatment on lacrimal gland function and on the local expression of VEGF and NGF in rats. Tear function was measured in 3 months old rats by modified Schirmer test at baseline and after 3 weeks of topical anti-VEGF eye drop treatment. Whole lacrimal glands from rats were removed after treatment and analysed by ELISA for VEGF and NGF levels. To investigate if the effects of anti-VEGF were mediated by changes in the NGF-pathway, we repeated the experiments in RCS rats, a strain with NGF-pathway impairment associated with decreased tear flow. After topical treatment with anti-VEGF eye drops, an increase in tear secretion was observed in both wild-type and RCS rats. A significant decrease of VEGF levels was also observed in lacrimal glands of both RCS and SD rats, accompanied by a significant increase in NGF levels. Inhibition of VEGF at the ocular surface in rats results in changes of tear function and lacrimal gland levels of VEGF and NGF. Further studies on the VEGF/NGF cross-talk at the ocular surface may expand our knowledge on the pathogenesis of several diseases characterized by tear dysfunction
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