1,721,091 research outputs found

    Psicoterapie della Gestalt. Integrazione dell'Evoluzione Pluralistica.

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    T cell metabolism and susceptibility to autoimmune diseases

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    During an immune response, T cell differentiation and function are tightly regulated to ensure protection against pathogens and prevent the autoimmune attack versus self-antigens. It is now established that cellular activation is coupled to profound changes in cellular metabolism. Indeed, pathways that control immune cell function and metabolism are intimately related, and different metabolic programs have been shown to control specific T cell fate. This review aims to provide an integrated view of T cell metabolism and of the molecular pathways controlling an appropriate T cell receptor (TCR) engagement. We describe here how different aspects of metabolism can influence T cell functions, focusing on the emerging role of the key metabolic pathways regulating T cell activation and their alterations in different autoimmune conditions. Manipulating these programs or their substrates could provide insights into mechanisms involved in inflammatory/autoimmune conditions, unveiling the potential for developing novel therapeutic approaches to treat these diseases

    Images of Violence from Mexico: A performance art based enquiry

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    The aims of this research have been: To create images and sculptures and explore their use in performative actions; To conduct a practice-based research project that examines how representations of human violence are explored through performance, while maintaining ethical value in aesthetic perception; and To develop a methodology in performance art through which I express my work as practice and the use of myself as a participant. These aims have been informed by the blurring of perceptions of space, authenticity, and notions of the global and local; by designing a theoretical framework informed by the concept of ‘Capitalismo Gore’; by traversing a methodology that juxtaposes the performer with images of violence from Mexico, situates the performer as a locus of tension between two different communities (Mexican and British), and engulfs the performer in affective responses to Mexican victims of violence. This art-practice based research is supported by a theoretical framework that refers to the term ‘Capitalismo Gore’ as the most relevant philosophical reference to address the narrative of extreme violence happening in Mexico during the war on drugs (Valencia, 2008). This art practice invites the readers to traverse a self-narrative constructed with feedback gathered from the audience and dialogues with artists and curators of a set of performance art methodologies. These performance art methodologies juxtapose the artist-scholar with images of violence from Mexico. Moreover, the affects produced by these performances have been transformed into visual documentation, some of them in the form of zines. Booklets are a simple way to show images and to distribute them among a wider audience. They are easy to transport and can be displayed in galleries, libraries, art fairs, book fairs. They demonstrate an important testimony for this research, situated as it is between two cultures, Mexican and British. The overall methodology not only appropriates performance methods such as Ewa Partum’s active poetry, but it also introduces them into an academic context and regenerates them by replacing Partum’s performance symbols with different symbols. The development of art practice-based research emphasises the need to avoid situating the performer in the place of the victims. It seeks at some moments to place the performer next to them, sharing part of their distress and hope through performance artistic practices and its documentation. The research has generated exploratory insights through the spatial aspect of my artistic practice, the spaces in which the performances occurred and the spaces generated by these performances

    A Cluster Analysis of High School Students' Styles of "Living-Together" in the Classroom

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    Students' experience of life in class has a pivotal role in their well-being. This study aims to identify homogeneous groups of students who have different perceptions about their "living-together" in class. A self report questionnaire was administred to a sample of 1,917 10th grade Italian students (52% females; M age = 15, SD= .7). Specifically, it included PYC ("How Do You Perceive Your Classroom?") inventory to measure student perception of "living-together", three student satisfaction items and ten items values scale. Findings showed four different students' Styles of Living-Together in Classroom that affect in different ways student well-being. (C) 2011 Published by Elsevier Ltd. Selection and/or peer-review under responsibility of Dr. Zafer Bekirogullari
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