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Use of cyproterone acetate, finasteride, and spironolactone to treat idiopathic hirsutism
No full textOBJECTIVE: To compare the effectiveness of cyproterone acetate, finasteride, and spironolactone in the treatment of idiopathic hirsutism.
DESIGN: Prospective randomized clinical study.
SETTING: University hospital.
PATIENT(S): Forty-one women (median age, 21 years [range, 18-34 years]) with idiopathic hirsutism who had requested to use an oral contraceptive.
INTERVENTION(S): Patients were randomly assigned to receive cyproterone acetate (12.5 mg/d for the first 10 days of the cycle), finasteride (5 mg/d), or spironolactone (100 mg/d) for 12 months. Follow-up was done at the end of therapy.
MAIN OUTCOME MEASURE(S): Ferriman-Gallwey score before treatment, at 6 and 12 months of treatment, and 1 year after the end of treatment, and androgenic profile before and after treatment.
RESULT(S): At the end of therapy, the Ferriman-Gallwey score decreased by 38.9%, 38.6%, and 38.5% in patients who used cyproterone acetate, finasteride, and spironolactone, respectively. One year after therapy, the Ferriman-Gallwey score of patients who used spironolactone was significantly lower (6.74 +/- 1.41) than that of patients who used either cyproterone acetate (7.92 +/- 1.08), or finasteride (9.08 +/- 0.99). The androgenic profile did not change significantly during treatment.
CONCLUSION(S): In patients with idiopathic hirsutism, the short-term results of treatment with cyproterone acetate, finasteride, and spironolactone are similar, but spironolactone is effective for a longer time
Effects of cyproterone acetate, finasteride, and spironolactone in patients with idiopatic hirsutism. Short- and long-term results
No full textHirsute women (Ferriman-Gallwey score > 6), with both normal ovulatory function (history of regular menstrual cycles and progesterone levels > 13 nmol/L in luteal phase) and normal circulating androgen levels, were defined as having idiopatic hirsutism (IH). Hirsutism affects between 5-10% of female patients, but according to the above definition only 5-15% of hirsute women may have IH. The aim of this study was to evaluate the effects of 12-months cyproterone acetate (25 mg/day for the first 10 days of the cycle), finasteride (5 mg/day), and spironolactone (100 mg/day) administration in patients with IH who received in addition an oral monophasic contraceptive (ethiniyl estradiol 0.03 mg + gestodene 0.075 mg, or ethinyl estradiol 0.05 mg + L-norgestrel 0.5 mg, 21 days/month).
Thirty-three women (mean age 23.64±5.30 years, range 17-34 years) with an overall Ferriman-Gallwey (FG) score of 11.39±1.37 (range 8-14) were studied. The analysis of variance showed a significant correlation between age and FG score (r=0.059213, F=165.58, p=0.00). Patients were divided into three groups, according to the different treatment they were to receive: Group A (cyproterone acetate), 12 (36.4%) patients, Group B (finasteride), 12 (36.4%) patients, and Group C (spironolactone), 9 (27.2%) patients. Free testosterone (FT), dehydroepiandrosterone sulphate (DHEAS), androstenedione (AD), and 17-OH-progesterone (17OHP) serum levels were recorded before treatment, 6 and 12 months later, and 6 months after it was suspended. Basal FG scores were 11.17±1.27 (Group A), 12.08±1.08 (Group B), and 10.78±1.56 (Group C). Mean age, basal FG score, and basal hormonal data did not differ (p=NS) among the three groups.
Six months from the beginning of the therapy FG score decreased (p<0.05) in all patients: Group A=7.17±1.27 (55.8%), Group B=8.08±1.08 (49.5%), Group C=7.89±0.93 (36.6%). In Groups A and B the clinical improvement was significantly (p<0.05) higher. A further slight (p=NS) decrease of 5.0%, 8.9%, and 14.4% in Groups A, B, and C, respectively, was observed 6 months later, when the treatment was suspended. Final FG scores were similar (p=NS) in all patients: Group A=6.83±0.99 (63.5%), Group B=7.42±1.38 (62.8%), and Group C=6.89±1.54 (56.5%). FT, DHEAS, AD, and 17OHP mean serum levels did not change significantly (p=NS) during the treatment. No adverse reactions or particular side effects were observed, and in
general the patient tolerance was good. Six months from the end of the therapy the FG score was 7.92±1.08, 9.08±0.99, and 7.67±1.41 in Groups A, B, and C, respectively, and its increase was significantly (p<0.05) higher in Groups A and B.
In conclusion, in patients with IH the short-term effects of finasteride, cyproterone acetate and spironolactone are similar. Following the suspension of therapy clinical improvement may remain for a long time in patients who undergo spironolactone therapy
Thalidomide and sensory neurotoxicity: A neurophysiological study.
No full textIF=4.869 - Q1, secondo autore: punti 1
1st International Conference on Cutaneous Lupus Erythematosus. DÃ1⁄4sseldorf, Germany, September 1-4, 2004
No full text
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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