1,244 research outputs found
Impaired Diurnal Pattern of Meal Tolerance and Insulin Sensitivity in Type 2 Diabetes: Implications for Therapy
No full text: To assess the diurnal patterns of postprandial glucose tolerance and insulin sensitivity, 19 subjects with type 2 diabetes (8 women; 60 ± 11 years; BMI 32 ± 5 kg/m2) and 19 anthropometrically matched subjects with no diabetes (ND; 11 women; 53 ± 12 years; BMI 29 ± 5 kg/m2) were studied during breakfast (B), lunch (L), and dinner (D) with identical mixed meals (75 g carbohydrates) on 3 consecutive days in a randomized Latin square design. Three stable isotopes of glucose were ustilized to estimate meal fluxes, and mathematical models were used in estimating indices of insulin action and β-cell function. Postmeal glucose excursions were higher at D versus B and at D versus L in type 2 diabetes (P < 0.05), while in ND they were higher at D versus B (P = 0.025) and at L versus B (P = 0.04). The insulin area under the curve was highest at B compared with L and D in type 2 diabetes, while no differences were observed in ND. Disposition index (DI) was higher at B than at L (P < 0.01) and at D (P < 0.001) in ND subjects, whereas DI was low with unchanging pattern across B-L-D in individuals with type 2 diabetes. Furthermore, between-meal differences in β-cell responsivity to glucose (F) and insulin sensitivity (SI) were concurrent with changes in the DI within groups. Fasting and postmeal glucose, insulin, and C-peptide concentrations, along with estimates of endogenous glucose production (EGP), Rd, SI, F, hepatic extraction of insulin, insulin secretion rate, extracted insulin, and DI, were altered in type 2 diabetes compared with ND (P < 0.011 for all). The data show a diurnal pattern of postprandial glucose tolerance in overweight otherwise glucose-tolerant ND individuals that differs from overweight individuals with type 2 diabetes. The results not only provide valuable insight into management strategies for better glycemic control in people with type 2 diabetes, but also improved understanding of daytime glucose metabolism in overweight individuals without impaired glucose tolerance or overt diabetes
Effects of Hyperglycemia and Hyperinsulinemia on Glucose Turnover during Exercise in Type 1 Diabetes
No full text224-OR: Diurnal Pattern of Insulin Action and Beta-Cell Function in Health and Type 2 Diabetes
No full textInsulin-independent glucose utilization during exercise is impaired in type 1 diabetes: a new model based analysis.
No full textCorrection to: When terminology hinders research: the colloquialisms of transitions of control in automated driving (Cognition, Technology & Work, (2022), 10.1007/s10111-022-00705-3)
No full textIn the original article, author affiliation published with error. The correct affiliations are: Davide Maggi—Institute for Transport Studies, Leeds, UK. Richard Romano—Institute for Transport Studies, Leeds, UK. Oliver Carsten—Institute for Transport Studies, Leeds, UK. Joost C. F. De Winter—Faculty of Mechanical, Maritime and Materials Engineering, Delft University of Technology, Delft, The Netherlands. The original article has been corrected.Human-Robot Interactio
1377-P: Pramlintide Lowers Postprandial Glucagon Concentrations by Inhibiting Glucagon Secretion without Altering Clearance in Type 1 Diabetes: A [13C15N]-Glucagon Study
No full textAdmiel Kosman, Siamo giunti a Dio
No full textInternational audienceSix poems from Israeli poet Admiel Kosman translated from the Hebrew into Italian. Selection of poems, presentation of the author, translation and notes by Davide Mano
Admiel Kosman, Siamo giunti a Dio
No full textInternational audienceSix poems from Israeli poet Admiel Kosman translated from the Hebrew into Italian. Selection of poems, presentation of the author, translation and notes by Davide Mano
Starchitecture: Scenes, Actors and Spectacles in Contemporary Cities
No full textHow and why do spectacular buildings get commissioned and procured? What are their visible urban effects? What can urban planners, architects, and policymakers learn in order to engage in more successful citymaking?
In recent years, media and critical attention has been lavished on famous architects, and the contributions of their designs to the branding of cities. The post-“Bilbao effect” global landscape is one where cities compete for the highest-profile skyscrapers, cultural projects, and high-profile developments designed by star architects whom even casual readers know by first name: Frank Gehry, Bjarke Ingels, Jean Nouvel, Zaha Hadid, Norman Foster, Rem Koolhaas. Far less is known about the decision-making processes behind these projects and their subsequent urban effects.
A unique combination of urban studies and photography, Starchitecture investigates projects designed by star architects in cities including Paris, New York, Abu Dhabi, Bilbao, and the architectural microcosm of the Vitra campus in Weil am Rhein, Germany. Author Davide Ponzini and photographer Michele Nastasi seek to explain and critique a growing global condition by revealing how starchitecture has been and continues to be deployed in cities around the world. The arguments they raise are vital to understanding the urban landscapes of today, and tomorrow
A Model of Glucose Production During Exercise in Normal and Ttype 1 Diabetic Subjects
No full textPrimo studio condotto sullo sviluppo di un modello capace di descrivere la produzione endogena di glucosio durante l'esercizio in soggetti sani e diabetici di tipo 1. Il modello selezionato include l'effetto dell'esercizio sulla sensibilità insulinica, un effetto ritardato dell'insulina, un effetto immediato del glucosio, un effetto immediato del glucagone su EGP. Si è ottenuto un buon fit per i soggetti sani, maggiori studi sono necessari per i soggetti diabetici.openEmbargo temporaneo per motivi di segretezza e/o di proprietà dei risultati e/o informazioni sensibil
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