203 research outputs found
Cybersecurity Education - Answering the Questions that Smaller Businesses are Asking
No full textCybersecurity is a global contemporary issue concerning the management and utilization of information technology (IT) (Kelley, 2008). Cybersecurity supports social sustainability goals as it is a frequently used tool for data management to secure data and protect privacy (Piccarozzi, et al. 2023). Cybersecurity is integral in maintaining the freedom and dignity of the individual, and greater awareness and strong multi-stakeholder partnerships are crucial for achieving the Sustainable Development Goals (SDGs) in a hyper-connected and digitized world (Michael, et al. 2019). Cyber threats represent IT leaders’ biggest concern (Kappelman et al., 2019). While more big companies are hacked, smaller businesses are attacked more frequently, with one in five small to medium businesses being hacked yearly (Segal, 2022). Smaller businesses report affordability barriers preventing them from accessing technologies, trained cyber security staff, and external security services that can keep their organizations safe from cyber-attacks (Cynet, 2022). Access to the Standards and Framework may represent another barrier for smaller businesses. The Australian Government has committed to ensuring that small business support programs are easy to understand and accessible, and that businesses have strong incentives to participate (Department of Home Affairs, 2023). This research attempts to remove the barriers to accessing rich resources in cybersecurity Standards and Frameworks to improve the cybersecurity maturity of smaller Australian businesses. Hence, the research question addressed in this paper is, “How can the Standards and Frameworks be used to educate smaller businesses about cybersecurity?” This research provides a scholarly contribution to support the Australian’s Governments commitment to provide understandable and accessible Cybersecurity Standards and Frameworks to educate smaller business
Treatment of refractory infectious keratitis with corneal collagen cross-linking window absorption
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Industry-based IT Certifications in Higher Education Institutions:A Stakeholder Perspective
No full textIndustry-based certifications (IBC) are one way to provide credentials to learners in Higher Education Institutions (HEI) with product-specific skills (e.g., Low-Code development) that can complement academic degrees (e.g., Business Informatics). To understand the ecosystem of industry-based certifications in the context of HEI, we first visualize stakeholders using the influence and affected features of a rainbow diagram. In this opinion paper, we draw on our personal experiences to understand the opportunities and challenges stakeholders face through the lens of Curriculum Theory to determine that IBC is a recognized way of learning IT skills in a Higher Education Institution. By applying a case study in an Australian university, we explore the challenges and potential of IBC to create value (social, functional, and emotional) to stakeholders in the ecosystem. We will discuss how we integrated the Low-Code development content in an undergraduate and postgraduate course at a mid-sized university. We make several recommendations that could be adopted by stakeholders to drive strategic decision-making.</p
High fluence iontophoretic corneal collagen cross-linking: in vivo OCT imaging of riboflavin penetration
No full textIontophoresis-Assisted Corneal Collagen Cross-Linking with Epithelial Debridement: Preliminary Results
Full text linkProgression of keratoconus in patients while awaiting corneal cross-linking: A prospective clinical study
No full textPURPOSE: To assess topographical changes in patients with keratoconus while awaiting corneal cross-linking (CXL) treatment. METHODS: In this prospective, double-center, observational clinical study, patients with keratoconus were enrolled. Progression was defined as a change in the curvature within the cone area of at least 1.00 diopter (D) on tangential map and a thinning of 20 m at the thinnest point after measurements taken at least 3 months apart. Morphological parameters were assessed at baseline (day of listing for CXL) and on the day of CXL treatment, including slit-lamp biomicroscopy, keratometry (maximum, minimum, and mean), and thinnest corneal thickness using corneal tomography (Pentacam; Oculus Optikgeräte GmbH, Wetzlar, Germany). RESULTS: One hundred four eyes of 104 patients were included. The waiting time was 84.8 ± 62.9 days. Twenty-five percent of patients showed evidence of progression while waiting for treatment. Patients who progressed while waiting for treatment were younger (22.2 ± 6.79 years) compared to those who did not show evidence of progression (25.4 ± 5.62 years) (P = .02). Stratification by age groups showed a significant worsening of maximum keratometry of 1.18 ± 1.37 D in patients younger than 18 years compared to those 18 to 26 years of age and those older than 26 years (P = .002 and .042, respectively). The multivariate model confirmed that the progression steepening of the maximum keratometry while waiting for treatment was associated with age (P = .028). CONCLUSIONS: The results suggest that stratification of waiting time according to the patient's age is required to reduce the risk of further progression of keratoconus
Iontophoresis-Assisted Corneal Collagen Cross-Linking with Epithelial Debridement: Preliminary Results
No full textPurpose. To report the early outcomes of iontophoresis-assisted corneal collagen cross-linking procedure with epithelial debridement (I-SCXL). Methods. Twenty eyes of twenty patients with progressive keratoconus were included in this prospective clinical study. Best spectacle corrected visual acuity (BSCVA), sphere and cylinder refraction, corneal topography, Scheimpflug tomography, aberrometry, anterior segment optical coherence tomography (AS-OCT), and endothelial cell count were assessed at baseline and at 1, 3, and 6 months of follow-up. The parameters considered to establish keratoconus progression were always proven with differential maps as change in curvature in the cone area of at least 1 diopter obtained with an instantaneous map. Results. Functional parameters showed a significant improvement (p 0.05). Conclusion. The early results indicate that the I-SCXL may be able to reduce the treatment time and improve the riboflavin diffusion
Transepithelial iontophoresis versus standard corneal collagen cross-linking: 1-year results of a prospective clinical study
Full text linkPURPOSE: To compare 1-year transepithelial corneal collagen cross-linking with iontophoresis (I-CXL) outcomes with standard CXL (S-CXL) epithelium-off for progressive keratoconus. METHODS: Forty eyes of 40 patients with progressive keratoconus were included in this comparative, prospective clinical study. Corrected distance visual acuity (CDVA), spherical equivalent, cylinder refraction, cor-neal topography, Scheimpfug tomography, aberrometry, and endothelial cell count were assessed at baseline and at 1, 3, 6, and 12 months of follow-up. RESULTS: Patients received either I-CXL (20 eyes) or S-CXL (20 eyes). Functional parameters (visual acuity and aberrometry) showed a significant improvement (P . 05). CONCLUSIONS: The 1-year outcomes suggest that I-CXL might be comparable to S-CXL in stabilizing the progression of the degenerative ectatic disease. Additionally, quicker improvement of functional parameters was reported in the I-CXL group
Improving the quality of protein NMR structures by Rosetta refinement and its application in molecular replacement
No full textThis dissertation demonstrates restrained Rosetta refinement can improve the quality of protein NMR structures and describes a protocol to improve their phasing power. Recent studies manifest unrestrained Rosetta refinement can improve the stereochemical quality and geometry of protein NMR structures, to move NMR structures closer to their X-ray counterparts and consequently to improve their phasing power in a few cases. In this study, we intend to explore whether those observations stand corrected in general and the impact of incorporating NMR experimental restraints into Rosetta refinement. We developed a newer version of PdbStat software to convert Cyana/Xplor formatted restraints into Rosetta formatted restraints. Based on a dataset of 41 NESG NMR/X-ray structure pairs, we have done unrestrained and restrained Rosetta refinement for all the NMR structures. The knowledge based structural quality Z-scores are significantly improved by Rosetta refinement with or without restraints. Compared with unrestrained Rosetta refined structures, restrained Rosetta refined structures fit the experimental data better, are in better agreement with their X-ray counterparts and are generally of better phasing power, while unrestrained Rosetta refinement often drives the NMR structures further from their X-ray counterparts especially when the structural similarity between NMR structures and X-ray structures is high. To summarize, a majority of the experimental NMR restraints still apply for X-ray crystal structures determined at crystalline environment, and they can be utilized to guide Rosetta refinement to improve the quality of NMR structures. Molecular replacement (MR) is widely used for addressing the phase problem in X-ray crystallography. Historically, crystallographers have had limited success using NMR structures as MR search models. Here, we report a comprehensive investigation of the utility of protein NMR structures as MR search models, using a dataset of 25 NESG NMR/X-ray structure pairs. Starting from NMR ensembles prepared by an improved protocol, FindCore, correct MR solutions were obtained for 22 targets. Rosetta refinement of NMR structures provided MR solutions for another two proteins. We also demonstrate that such properly prepared NMR ensembles and X-ray crystal structures have similar performance when used as MR search models for homologous structures, particularly for targets with sequence identity >40%.Ph. D.Includes bibliographical referencesIncludes vitaby Binchen Ma
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