1,721,793 research outputs found

    Informational Cascades in Financial Economics: A Review

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    The paper surveys and appraises the recent theoretical research on informational cascades and herding behavior in capital markets. Standard models of informational cascades hardly apply to capital markets where all publicly available information is reflected in the price. The paper briefly describes the situations in which an informational cascade may take place also in the context of financial markets and shows how herding can help to explain bubbles and crashes

    Targeting TGFbeta-mediated processes in cancer

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    TGFbeta is a pleiotropic cytokine that has regulatory roles during embryonic development and adult tissue homeostasis, and is especially important for epithelial, neural and immune system differentiation and function. An increasing number of literature reports support a role for autocrine and paracrine TGFbeta-mediated processes in cancer. Progress in delineating the effects of TGFbeta in different tumors and stages of cancer has stimulated the development of TGFbeta-targeted therapies. This review describes the causes of TGFbeta malfunction in cancer, the rationale for therapeutic targeting of TGFbeta in human neoplasia, and the molecular strategies to modulate the signal
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