1,720,988 research outputs found
Biological therapy for dermatological manifestations of inflammatory bowel disease.
No full textUlcerative colitis and Crohn’s disease are the
best known forms of inflammatory bowel disease (IBD)
and are considered immune-mediated disorders of unknown
etiology that primarily affect the gastrointestinal
tract. In addition, other organ systems can be involved,
such as skin. Erythema nodosum, pyoderma gangrenosum
and psoriasis are the dermatological comorbidities
often associated with it. The anti-tumor necrosis factor
(TNF)-α drugs (infliximab and adalimumab) have
significantly changed the management of these conditions.
In this brief review, we provide an overview on
the prevalence and clinical aspects of the more commonly
reported skin manifestations of IBD and the role
of TNF-α inhibitors in their treatment
Schwannoma of the rectum: A case report and literature review.
No full textSchwannomas of the colon and rectum are
tumors that are rarely detected. For achieving a definitive
histopathological diagnosis, the use of an appropriate
immunohistochemical panel is request. Although
schwannomas are considered to be benign tumors,
their risks of recurrence must be not ignored. The
best therapeutic option is complete surgical removal.
In the present study, we describe a case of a rectal
schwannoma occured in a 72-year-old man, presented
as a small sessile polypoid lesion, which was successfully
removed in toto by hot-biopsy, during the same
procedure. No recurrence of the lesion was observed
after 6 mo of follow-up
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Azathioprine treatment in inflammatory bowel disease patients: type and time of onset of side effects
No full textBACKGROUND: Azathioprine
(AZA) and 6-mercaptopurine (6-MP), purine analogues,
are the immunosuppressant drugs most
frequently used for inducing and maintaining remission
in inflammatory bowel disease (IBD). The
occurrence of adverse effects is a major drawback
in the use of these drugs, and short- and long-term
toxicity represent a major limitation to their use.
AIM: The present study investigated the prevalence,
type and time of onset of AZA-related adverse
events, in a cohort of IBD patients in a single
referral Centre.
PATIENTS AND METHODS: The records of
consecutive IBD outpatients, referred to our Institution
between 1987-2009, were retrospectively
evaluated.
RESULTS: We reviewed 2014 patients, in
whom AZA was prescribed in 302 of them, 139
(46%) with ulcerative colitis (UC) and 163 (54%)
with Crohn’s disease (CD). Side-effects were
complained by 98 (32.4%) out of 302 patients, 50
UC and 48 CD, (36% UC vs 29.4% CD, p = 0.26).
In 20 (20.4%) patients, 11 UC and 9 CD, side-effects
r
Hematological malignancies in chronic inflammatory bowel diseases: Report of five cases and review of the literature
No full textSeveral forms of primary and secondary hematological malignancies were rarely observed during the clinical course of inflammatory bowel diseases (IBD). Patients needing a prolonged treatment with immunosuppressants, such as azathioprine or methotrexate, with familiarity and genetic predisposition seem to be at a higher risk of leukemia. On the other hand, asthenia, thickness, and fever may be the symptoms of the onset of each kind of hematological malignancy. The finding of anemia, alteration of leukocyte count and large undetermined cells may suggest increased probability of abnormal proliferation of a single white blood cell line. In this report, the occurrence of hematological malignancies is described in five patients affected by IBD (three with ulcerative colitis and two with Crohn's disease) attending our Gastroenterology Unit. © Springer-Verlag 2006
Endoscopic papillary balloon dilation for difficult common bile duct stones: Our experience.
No full textAIM: To evaluate the efficacy and safety of endoscopic
balloon dilation (EBD) performed for common bile duct
(CBD) stones.
METHODS: From a computer database, we retrospectively
analyzed the data relating to EBD performed in
patients at the gastrointestinal unit of the Sandro Pertini
Hospital of Rome (small center with low case volume)
who underwent endoscopic retrograde cholangiopancreatography
(ERCP) for CBD from January 1, 2010
to February 29, 2012. All patients had a proven diagnosis
of CBD stones studied with echography, RMNcholangiography
and, when necessary, with computed
tomography of the abdomen (for example, in cases
with pace-makers). Prophylactic therapies, with gabexate
mesilate 24 h before the procedure and with an antibiotic
(ceftriaxone 2 g) 1 h before, were administered
in all patients. The duodenum was intubated with a
side-viewing endoscope under deep sedation with intravenous
midazolam and propofol. The patients were
placed in the supine position in almost all cases
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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