1,720,964 research outputs found
L-alpha-glycerylphosphorylcholine antagonizes scopolamine-induced amnesia and enhances hippocampal cholinergic transmission in the rat.
No full textThe effects of L-alpha-glycerylphosphorylcholine (alpha-GPC) on scopolamine-induced memory impairment and on brain acetylcholine (ACh) synthesis and release were investigated in rats. Oral administration of alpha-GPC 3 h before the behavioural test prevented the learning impairment induced by scopolamine given 30 min before the acquisition of a passive avoidance response. Similarly, retrograde amnesia induced by scopolamine, given immediately after acquisition training, was also completely reversed by the drug. These effects were dose-dependent with a maximum at 300 mg/kg. The mechanism of action of this compound was investigated by measuring hippocampal ACh synthesis and release both in vivo by means of the microdialysis technique and in vitro in tissue slices. alpha-GPC dose dependently increased ACh release with a maximum at 300 mg/kg. In addition, i.v. injection of [14C]alpha-GPC resulted in [14C]ACh formation. The data suggest that the behavioural effects of alpha-GPC may be related to its property to increase hippocampal ACh synthesis and release
L-alpha-glycerylphosphorylcholine antagonizes scopolamine-induced amnesia and enhances hippocampal cholinergic transmission in the rat
No full textmGluR5 metabotropic glutamate receptor distribution in rat and human spinal cord: a developmental study.
No full textStudio epidemiologico del virus dell'epatite C: correlazione tra distribuzione genotipica e viremia
No full textStudio relativo alla distribuzione genotipica del virus dell'epatite C e correlazione con la viremia. Nella popolazione di pazienti da noi presa in considerazione (332 pazienti), i genotipi più diffusi nella fascia d'età 20-40 anni sono 1a e 3a, mentre nella fascia d'età 40-60 anni prevalgono i genotipi 1b e 2a/2c; inoltre è stata rilevata una correlazione significativa tra alti livelli viremici ed il genotipo 1b
Repeated reserpine administration up-regulates the transduction mechanisms of D1 receptors without changing the density of [3H]SCH23390 binding
No full text
Diagnostic aspects of cutaneous lesions due to Histoplasma capsulatum in African AIDS patients in nonendemic areas.
No full textNo abstrac
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