1,721,029 research outputs found
Letter to the Editor on “Gastrointestinal tract reconstruction in adults with ultra-short-bowel syndrome. Surgical and nutritional outcomes”
Full text linkStudi stereochimici su prodotti da sintesi stereoselettive, di composti di interesse farmaceutico
No full textComment on klek et al. Enhanced recovery after surgery (eras) protocol is a safe and effective approach in patients with gastrointestinal fistulas undergoing reconstruction: results from a prospective study. nutrients 2021, 13, 1953
Full text linkWe read and appreciated the prospective study by Klek et al. [1] recently published in Nutrients: an ERAS (Enhanced Recovery After Surgery) protocol was used by the authors to reduce post-operative complications in all subjects scheduled for surgery due to enterocutaneous fistulas, collecting a consecutive series of 100 patients between 2011 and 2020. The ERAS protocol was successfully applied even though few modifications of the original plan were introduced in 2015, dividing the patients in two groups (2011–2015 and 2016–2020): a statistically significant improvement of surgical outcomes was shown by the authors, reporting a reduction of postoperative nausea and vomiting, overall complication rate, and median length of hospital stay (overall and after surgery)
Phytoliposome-based silibinin delivery system as a promising strategy to prevent hepatitis C virus infection
No full textLiposomes are nanocarriers able to solubilize and deliver a wide range of hydrophobic pharmaceuticals and to increase drug bioavailability. They show a natural tendency to hepatic accumulation, and thus represent an optimal drug delivery system for the treatment of liver diseases, including chronic virus hepatitis C. Silibinin, the main and more active component of the seed extract from Silybum Marianum, is a hydrophobic flavolignan emerging as an alternative medication for the treatment of hepatitis C virus infection, as it has been shown to inhibit hepatitis C virus entry and replication. In this study we compared cellular delivery and antiviral activity of silibinin encapsulated into phytoliposomes or not, used at the aim to overcome its poor water-solubility and bioavailability. First, it was confirmed the inhibitory activity manifested by lipid-free silibinin in preventing hepatitis C virus entry into the cells. Our data clearly demonstrated that phytoliposomeencapsulated silibinin was absorbed by the cells 2.4 fold more efficiently than the free molecule and showed a three hundreds fold more potent pharmacological activity. Moreover, we surprisingly observed that phytoliposomes themselves inhibited virus entry by reducing the infectivity of viral particles. Based on these observations, phytoliposomes used in this study might be proposed as a delivery system actively contributing to the antiviral efficacy of the encapsulated drug
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Phyto-liposomes as nanoshuttles for water-insoluble silybin–phospholipid complex
No full textAmong various phospholipid-mediated drug delivery systems (DDS) suitable for topic and oral
administration, phytosome technology represents an advanced innovation, widely used to incorporate
standardized bioactive polyphenolic phytoconstituents into phospholipid molecular complexes. In order
to extend their potential therapeutic efficiency also to other routes of administration, we proposed a
novel phytosome carrier-mediated vesicular system (phyto-liposome) as DDS for the
flavonolignan
silybin (SIL), a natural compound with multiple biological activities related to its hepatoprotective,
anticancer and antioxidant (radical scavenging) effects. We screened the optimum fraction of its
phytosome, available in the market as SiliphosTM, into liposomes prepared by extrusion, such that vesicle
sizes and charges, monitored through dynamic light scattering and laser doppler velocimetry, satisfied
several quality requirements. Special emphasis was placed on the study of host-guest interaction by
performing UV–vis absorption, spectrofluorimetry and NMR experiments both in aqueous and non-polar
solvents to probe the effect of the presence of phospholipids on the electronic properties of SIL and its
propensity to engage H bonding with the lipid headpolar groups. Finally,
fluorescence microscopy
observations confirmed the ability of phyto-liposomes to be internalized in human hepatoma cells,
which was promising for their potential application in the treatment of acute or chronic liver diseases
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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