488 research outputs found

    The Journey from Australia to Italy of Alice Pung’s Bestselling Novel

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    Alice Pung's Unpolished Gem was translated into Italian in 2010. Giving some examples of the challenge this work of translation presented, Adele D'Arcangelo will try to put Pung's novel in the picture of a wider production of multicultural literature available in Italy. Positive aspects related to the reception of Gemma Impura in Italy will be pointed out as well as the vital and fundamental collaboration between author and translator. The innate potentialities of Unpolished Gem to transform a personal experience in a universal one were doubled by the translation of the book in another language, allowing a wider and more eclectic readership to become familiar with Alice's story, and making its Australian setting overcome the boundaries of language and spac

    Phosphenes in space: a study on the interaction between carbon ions and rod photoreceptor

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    I fosfeni, o light flash, sono stati percepiti per la prima volta durante il volo verso la luna della navicella Apollo. In genere sono avvertiti al buio, prima di addormentarsi. In questa tesi si studia l'ipotesi di una eccitazione dei fotorecettori della retina da parte di ioni pesanti (carbonio). Campioni di recettori dei bastoncelli vengono irradiati, e viene studiato l'effetto degli ioni carbonio su topo, attraverso la registrazione della risposta elettrofisiologica (segnale retinico e corticale). La tesi si e' sviluppata nell'ambito del progetto ALTEA (Anomaluos Long Term Effect on Astronauts) e tutti gli esperimenti relativi a questo lavoro sono stati svolti a terra. L’obiettivo di ALTEA e’ piu’ generale e riguarda lo studio del rischio funzionale sul sistema nervoso centrale degli astronauti dovuto alla particelle ionizzanti presenti in condizioni di microgravita’ durante le missioni spaziali a lungo termine; ALTEA include sia esperimenti a terra che in orbita, a bordo della Sazione Spaziale Internazionale. La tesi inizia con una introduzione al progetto ALTEA; nel secondo capitolo e’ descritto lo studio chiamato ALTEA-MICE (Mice intermittent Irradiation with Concurrent Electrophysiological monitoring). Nel terzo capitolo sono descritto il sistema costituito dai segmenti esterni dei bastoncelli bovini in sospensione e il meccanismo di attivazione dei fotorecettori. Nel quarto capitolo e quinto capitolo mi sono occupata della interazione radiazione – materia nei tessuti e del caso specifico dell’irradiazione dei campioni dei segmenti esterni contenenti la rodopsina. Nel quinto e ultimo capitolo viene presentato un modello che spiega l’isomerizzazione (attivazione) del retinale della rodopsina come prodotto dell’azione dei radicali liberi provenienti dalla radiolisi dell’acqua.Phosphenes, or light flashes, have been reported by astronauts since the first Apollo flights to the Moon. They are usually described as occurring in the dark and typically before falling asleep. The light flashes are thought to originate as an effect of high- energy particles interacting with the visual system. The study presented in this thesis investigates the hypothesis of a direct excitation of the rod photoreceptors inside the retina and in particular the interaction between carbon ions and rods. Also the retinal and cortical electrophysiological response of mice submitted to carbon ions irradiation have been studied. This thesis has been developed as a section of the ’Anomalous Long Term Effects on Astronauts’ (ALTEA) program, and all the experiments concerning this thesis took place on ground. The objective of the ALTEA project is more general, and is aimed to assess the functional risks on the central nervous system due to particle flux in microgravity conditions during long term space mission. ALTEA includes a series of experiments both in orbit and on ground. The experiments on board International Space Station will contribute to define the causes of the anomalous phosphene perception of the astronauts by detecting the incident particles through the head of the astronauts and concurrently monitoring the central nervous system functionality. The experiments on ground include the direct irradiation with carbon ions of the outer segments of the rods, and an animal model to investigate the retina/cortex responses of mice irradiated in controlled laboratory experiments. In these experiments on ground I directly contributed in the preparation, the test and the optimization of the experiments and in the following analysis of the data. The whole project has been supported by the Italian Space Agency. The outline of this thesis includes an introduction to the interdisciplinary ALTEA program in the first chapter. In the second chapter ALTEA-MICE (Mice intermittent Irradiation with Concur- rent Electrophysiological monitoring) study is described: the experimental sessions as well as the evidences in the electrophysiological responses of the mouse retina have been described in detail. My role has been chiefly the experimental set up, and I also collaborated on the data analysis. The main results of this investigations have been published. In the third chapter the system of the rod outer segments in suspension and the mechanism of the activation of the photoreceptors are described. The fourth chapter deals with the radiation effects in the biological tissue, and in the fifth chapter there is particular regard to the effects of radiation on samples containing a suspension of rods extracted from bovine retinae. The effects on the rod photoreceptor rhodopsin has been studied: measurements have been performed irradiating with carbon ions the outer segments of the rods in suspension. The amount of the isomeric transformations (bleaching) of the molecules of chromophore into the photoreceptor gives the extent of the effects of radiation. I collaborated to the experiment and carried out the following data analysis. Finally, in the sixth chapter the process of the photo-isomerization of rhodopsin is explained by a model: the process starts with the water radiolysis and the formation of hydroxyl radicals OH in order to achieve the lipid peroxidation, then there is the subsequent emission of visible photons which are responsible for the photoreceptor bleaching. Since rhodopsin is surrounded by phospholipids, present in high concentration in the disc membranes, the effect of chemiluminescence is proposed to be the cause of the photo-transduction cascade and the light flash perception as a consequence. In order to test this hypothesis, a series of experiments was aimed at studying the effects of the hydroxyl radicals produced in an enzymatic way. The main results of this work are illustrated in chapter six, and have been published

    Dr. Kate Adele Hill Collection

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    Finding Tool created by the West Texas Collection.Dr. Kate Adele Hill, a native of Travis County and the author of three books related to her work as a county home demonstration agent, was the granddaughter of Sam H. Hill, early Schleicher County settler. The family’s ranching interests were in Kerr, Schleicher, and Tom Green Counties, Her father was W.H. Hill. The collection includes four books, magazines, newspaper clippings, family photographs, and genealogy on the Hill family. Genealogy is located in the Vertical Files.Dr. Kate Adele Hil

    Analysis Of Idioms Found In Selected Song Lyrics Of Adele

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    This article discusses the analysis of idioms found in Adele song lyrics. The method used in this research is a qualitative approach. Data collection was carried out by the author through Adele song lyrics such as Easy on me, Rolling in the dark, Someone like you, Hello, Send my love and others. The final product features every idiom Palmer uses in select songs. Partial idiomatic phrases consist of 7 (70%) phrases, followed by phrasal verbs (2, 20%), and prepositional verbs (1, 10%). In some of Adele songs, some idioms terms with unique meanings derived from Adele songs dominate. There are many idioms, each with a special meaning. The researcher divides meaning into conceptual meaning, connotative meaning, theme meaning, emotive meaning, reflected meaning, stylistic meaning, and collactive meaning

    Le patine bianche sui dipinti delle tombe di Tarquinia: il moonmilk

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    The Etruscan tombs of Tarquinia hold a treasure, not visible to the naked eye, formed by a microbial community unique in the world. Over the centuries, microorganisms have produced a white patina that has covered the surfaces of these hypogeal environments. In some tombs this patina appears as a veil, while in others the thickness is a few centimeters. Further analysis has recently revealed that this patina is formed by a peculiar structure of calcium carbonate, called Moonmilk. The Moonmilk was formed over the centuries thanks to the metabolism of microorganisms and to specific environmental conditions. This article traces the history of the discovery of Moonmilk in the tombs of Tarquinia and presents a unique example of biocolonization that contributes to the protection of wall paintings and not to their degradation

    Altered Expression of the CB1 Cannabinoid Receptor in the Triple Transgenic Mouse Model of Alzheimer's Disease

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    The endocannabinoid system has gained much attention as a new potential pharmacotherapeutic target in various neurodegenerative diseases, including Alzheimer's disease (AD). However, the association between CB1 alterations and the development of AD neuropathology is unclear and often contradictory. In this study, brain CB1 mRNA and CB1 protein levels were analyzed in 3 × Tg-AD mice and compared to wild-type littermates at 2, 6 and 12 months of age, using in-situ hybridization and immunohistochemistry, respectively. Semiquantitative analysis of CB1 expression focused on the prefrontal cortex (PFC), prelimbic cortex, dorsal hippocampus (DH), basolateral amygdala complex (BLA), and ventral hippocampus (VH), all areas with high CB1 densities that are strongly affected by neuropathology in 3 × Tg-AD mice. At 2 months of age, there was no change in CB1 mRNA and protein levels in 3 × Tg-AD mice compared to Non-Tg mice in all brain areas analyzed. However, at 6 and 12 months of age, CB1 mRNA levels were significantly higher in PFC, DH, and BLA, and lower in VH in 3 × Tg-AD mice compared to wild-type littermates. CB1 immunohistochemistry revealed that CB1 protein expression was unchanged in 3 × Tg-AD at 2 and 6 months of age, while a significant decrease in CB1 receptor immunoreactivity was detected in the BLA and DH of 12-month-old 3 × Tg-AD mice, with no sign of alteration in other brain areas. The altered CB1 levels appear, rather, to be age-and/or pathology-dependent, indicating an involvement of the endocannabinoid system in AD pathology and supporting the ECS as a potential novel therapeutic target for treatment of AD

    Memoirs of Adele Sarpy Morrison.

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    Gilt top edge.Author's autograph presentation copy."One hundred copies of this book have been privately printed for distribution among friends of the author."Mode of access: Internet

    A Critical Discourse Analysis of Song "Easy on Me" by Adele

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    The purpose of this research is to analyze how the role or attitude of the author towards a song that was created by examining the effect, judgment, and appreciation. The researcher used descriptive qualitative method by using three analytical processes proposed by Fairclough's CDA model. The data from this research are the lyrics of Adele's song entitled "Easy on Me". The findings show that Adele describes her feelings in this song explicitly by using a figure of speech. In her song, Adele conveys the effect of how worried and devastated she is when faced with the problem of her divorce. In the aspect of assessment, Adele admires nature through her own point of view, so that some of her song lyrics are interpreted using the beauty and serenity of nature. Based on appreciation, Adele assesses that divorce or separation in a relationship is the end of her journey, so she wants to give up and surrender

    Patient Preferences for Home Exercise Program Provision: A Patient Survey

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    Abstract Date Presented 3/31/2017 This study examines patient preferences regarding delivery mode of home exercise programs. Understanding of patient preferences in rehabilitation supports client centeredness and patient–practitioner relationships and is recommended as an evidence-based technique to improve client adherence. Primary Author and Speaker: Kristin Valdes Additional Authors and Speakers: Adele Campbell</jats:p
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