1,355,068 research outputs found
Reliability and testing strategies in technical design: A case study of optimization and simulation
No full textOur research group integrating knowledge coming from different fields as aeronautical, mechanical and computer science engineering developed a new methodology to design electromechanical systems saving time and money. By means of an accurate analysis of the design techniques usually adopted, we conceived a seven step design strategy and in the paper we present a particular step of this process applied to a case study we solved with this new methodology. In particular the paper presents in detail two different brake caliper models, each having a well-defined purpose. It is illustrated the experimental validation we did in order to get the best optimization of the system. So described models are useful to design the brake caliper and evaluate its effect on the whole brake system in a cheap and fast way, saving money and achieving the target of guaranteeing reliability standard
Adalimumab is effective in achieving clinical and endoscopic long-term deep remission : a case report
No full textAnti-tumour necrosis factor-alpha has dramatically changed the natural history of Crohn's disease in the last decades. Adalimumab is effective in inducing and maintaining clinical remission as well as in inducing deep mucosal healing, which is a prognostic factor for further progression of the disease. Long-term treatment with adalimumab is considered safe and should be continued for at least 3 years in patients with aggressive long-standing Crohn's disease.We report the case of a 61-year-old woman with aggressive and complicated steroid-dependant Crohn's disease in whom clinical and endoscopic long-term deep remission was achieved for up to 3 years, without any need for steroids, hospitalization or surgery
Endoscopic mucosal resection-endoscopic submucosal dissection: Do we really need endoscopic ultrasonography assistance?
No full textEndoscopic mucosal resection has become the standard of care for early gastrointestinal cancer. The application of this new treatment requires an accurate stadiation of the neoplasia. The exclusion of nodal involvement and the evaluation of the depth of tumor penetration within the gastrointestinal wall is essential to select patients who can benefit from this approach. Echoendoscopy allows endoscopists to evaluate subde changes in the layers of the gastrointestinal wall giving an important aid to local tumor staging and planning the adequate treatment
Development of an electro-hydraulic brake system minimizing cost
No full textThe paper describes the procedure our research group followed to prototype an Electro-Hydraulic Braking system (EHB). The first step consisted in developing a model of the system, by using the softwares AMESim® and Simulink®. Then the Pedal Force Emulator (PFE) was designed in detail and built. A devoted Hardware-In-the-Loop (HIL) bench was used to test the prototype and the same procedure was followed for the hydraulic unit. It is important to underline that the principal target of the activity consisted in trying to adapt the standard components of a traditional braking system to develop a low cost EHB. Also devoted valves to connect the driver foot to the wheel calipers in case of fault were used to create a reliable failsafe system
Endoscopic submucosal dissection technique
No full textESD represents an efficient solution for the endoscopic treatment of neoplasia limited to the mucosal layer, its technique is complex and mimicks a "surgical" resection. ESD diffusion in our endoscopic structures will significantly increase our options for treatment of early neoplasms of the digestive tract
Hardware-In-the-Loop with active roll control
No full textActive Roll Control (ARC) is getting one of the most interesting technological innovations in the automotive industry during last years. The paper presents the method adopted by our research group to design Active Roll Control systems for automotive applications. Active Roll Control concept is presented in detail, both from the point of view of the targets and the practical realization. The design process consists of a first part involving the simulation of vehicle dynamics and the evaluation of the effects of the active system, without considering in detail the delays due to the actuation system. The second step of the process consists in simulating in detail the actuation system for ARC, by giving origin to a co-simulation between the same vehicle model and the detailed model of the actuation system. According to the results related to simulation, the actuation system is designed. The paper presents the list of the main problems connected with the structural design of ARC. The described process was carried on both for a hydraulic and an electro-mechanical ARC. Thirdly, the prototypes of both the systems are presented. The analysis of the effectiveness of their performance was implemented through devoted Hardware-In-the-Loop (HIL) test benches. They are described in detail, especially from the point of view of the connection between the hardware of the bench and the software simulating vehicle dynamics. The conclusion of the paper presents a comparison between the hydraulic and the electro-mechanical ARC, by putting in evidence the peculiarities of the solutions, which could be governed by similar control algorithms
Concerns on the very high complication rates reported after self-expanding metal stent (SEMS) placement for colorectal cancer in a Catalan retrospective study.
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