1,720,965 research outputs found
Il recupero farmacologico della sessualità nell’anziano.
No full textIl declino della funzione sessuale con l’età è oggi sempre più osservabile a seguito dell’allungamento della durata della vita, e la più frequente disfunzione diagnosticata è quella erettile. Con l’avanzare dell’età spesso intervengono anche altre modificazioni, come difficoltà con l’orgasmo e riduzione del volume seminale. A fronte di una riduzione della prevalenza dell’eiaculazione precoce con l’età, quella dell’eiaculazione ritardata segue un andamento opposto, pur rimanendo complessivamente piuttosto rara nella popolazione
Testosterone, invecchiamento e funzione muscolare.
No full textIl processo d’invecchiamento comporta una serie di modificazioni a carico dell’organismo umano che non risparmiano la muscolatura scheletrica. Il numero medio delle fibre muscolari e delle unità motorie mostra un declino di tipo lineare dopo i 50 anni. Circa il 50% fibre muscolari presenti all’età di 50 anni sono perse all’età di 80 anni, così come il numero delle unità motorie che può scendere da circa 200 a 75 in un singolo muscolo come l’estensore breve delle dita. La perdita delle unità motorie sembra essere la causa determinante la perdita delle fibre muscolari, le loro riduzioni numeriche hanno un inizio ed una progressione molto simili, ed è strettamente correlata al processo d’invecchiamento che si verifica anche nel sistema nervoso centrale. La perdita di fibre e unità motorie legate all’età coinvolge tutti i muscoli dell’organismo umano, ma interessano maggiormente i muscoli dove predominano le fibre tipo 2. Anche i processi rigenerativi del tessuto muscolare sono rallentati dal processo d’invecchiamento, infatti si osservano una progressiva diminuzione della capacità proliferativa delle cellule satelliti e una perdita nell’abilità di tali cellule di fondersi con le miofibre esistenti. A carico delle cellule satelliti si può inoltre osservare un declino nel loro numero accanto alle fibre tipo II e un aumento nelle fibre
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Nutritional status and follicular-derived thyroid cancer. An update
No full textThe incidence of differentiated thyroid cancer has been increasing in the last decades all over the world. Such a steady growth cannot be entirely attributable to more intensive thyroid nodule screening and more sensitive diagnostic procedures. Several environmental factors have changed with sufficient rapidity in the same time frame and may represent credible candidates for this increase. They include modified iodine intake, lifestyle-associated risk factors, exposure to various toxic compounds, pollutants and xenobiotics, nutritional deficiencies, eating habits and comorbidities. Foremost, nutritional patterns have gained high interest as possible promoters and modifiable risk factors for thyroid cancer in recent years. The aim of this narrative review is to focus on the relationship between thyroid cancer and nutritional factors, dietary habits and obesity. Low iodine intake has been associated to increased risk of thyroid cancer, favoring the development of more aggressive histotypes. Moreover, correction of iodine deficiency can shift thyroid cancer subtypes toward less aggressive forms, without affecting the overall risk for cancer. Actually, evidence regarding the association between selenium and vitamin D deficiency and thyroid cancer is very limited, despite their well-known anti-cancer potentials, and the clinical usefulness of their supplementation is still uncertain in this setting. Albeit the relationship between single foods and thyroid cancer is difficult to examine, fish and iodine-rich foods, vegetables, and fruits might exert protective effects on thyroid cancer risk. Conversely, no clear association has been found for other foods to date. Lastly, a clear association between obesity and the risk of thyroid cancer, with more aggressive behavior, seems to emerge from most studies, likely involving variations in thyroid function and chronic inflammation mediated by cytokines, insulin, leptin and adiponectins. Although no definite association between dietary factors and thyroid cancer has been firmly established so far, some nutritional patterns, together with excessive weight, seem to play a relevant role in thyroid cancer carcinogenesis as well as in its severity and aggressiveness. These effects may play an additive role to the well-established one exerted by environmental carcinogens, such as pollutants and radiation exposure
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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