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THE ROLE OF CARD15 MUTATIONS AND SMOKING IN THE COURSE OF DISEASE IN A MEDITERRANEAN AREA
No full text. Am J Gastroenterol. 2008 Mar;103(3):649-55.
The role of CARD15 mutations and smoking in the course of Crohn's disease in a
Mediterranean area.
Renda MC, Orlando A, Civitavecchia G, Criscuoli V, Maggio A, Mocciaro F, Rossi F,
Scimeca D, Modesto I, Oliva L, Cottone M.
Ematologia II Ospedale V. Cervello, Palermo, Italy.
AIM: To evaluate the role of CARD15 mutations and smoking in the main events of
Crohn's disease (CD).
PATIENTS AND METHODS: A total of 182 patients with CD were included in a
prospective study in order to evaluate the role of CARD15 mutations and smoking
in the main outcomes of disease course: first operation and surgical recurrence.
The following variables were evaluated in a univariable and multivariable
analysis: age, sex, site of disease, pattern, smoking habit, extraintestinal
manifestations, duration of disease, and CARD15 mutation. The Kaplan-Meier method
for survival curves and Cox model for multivariable analysis were, respectively,
used.
RESULTS: A total of 110 patients were operated on and 32 were reoperated on. The
7-yr cumulative free rate of surgery was 42% (95% CI 34-51%). At multivariate
analysis only stricturing and penetrating pattern were predictors of surgery (HR
1.7, 95% CI 1-2.8; HR 3.2, CI 1.8-5.5, respectively). The 7-yr cumulative free
rate of reoperation was 75% (95% CI 0.52-0.88). At multivariable analysis in the
model with any CARD15 mutation, only smoking habit at diagnosis (HR 3.6, 95% CI
1.4-9.1) was predictive of surgical recurrence. When single mutations were
considered in the model smoking (HR 4.2, 95% CI 1.8-10.1) and L1007fs mutation
(HR 2.9, 95% CI 1.1-7.3) were predictive of reoperation.
CONCLUSIONS: In CD, smoking predicts recurrence after surgery. The role of CARD15
mutations in the clinical course of CD remains undefined
Intestinal permeability and Genetic determinants in patients,first degree relatives,and controls in a High incidence area's of Crohn's disease in Southern Italy
No full text1. Am J Gastroenterol. 2005 Dec;100(12):2730-6.
Intestinal permeability and genetic determinants in patients, first-degree
relatives, and controls in a high-incidence area of Crohn's disease in Southern
Italy.
Fries W, Renda MC, Lo Presti MA, Raso A, Orlando A, Oliva L, Giofré MR, Maggio A,
Mattaliano A, Macaluso A, Cottone M.
Dipartimento di Medicina Interna e Terapia Medica, Università di Messina,
Messina, Italy.
OBJECTIVE: A defect of gastrointestinal barrier function is considered to
represent an important step in the pathogenesis of Crohn's disease (CD) but the
mechanisms leading to an increased intestinal permeability (IP) are poorly
understood. Since IP is influenced by pro-inflammatory mediators, it seems likely
that a genetically determined abnormal immune response may lead to a loss of
barrier function.
METHODS: In a geographic area in Southern Italy with high incidence of CD we
investigated IP (lactulose/mannitol testing) together with the three main
mutations of the NOD2/CARD15 and the D299G polymorphism of the toll-like receptor
(TLR)-4 gene in 23 families of CD patients (patients and first-degree relatives).
RESULTS: Forty-eight percent of CD patients and 40% of their healthy relatives
were found to have an abnormal IP compared to 5% of an appropriate control
population (p < 0.0001). IP, however, was not associated with the L1007finsC
mutation of the NOD2/CARD15 or the D299G variant of the TLR-4 gene. Allele
frequency of the only L1007finsC mutation of CARD15 was significantly increased
in patients (8.7%, p < 0.003) and in relatives (8.3%, p < 0.024) compared with
controls (2.4%), whereas the D299G variant of the TLR-4 gene was found to be
increased only in relatives (8.3%, p < 0.022), but not in patients (4.3%)
compared with the control population (1.7%).
CONCLUSIONS: There was no association between IP and genetic markers. Our
findings showed a very high proportion of healthy first-degree relatives to bare
alterations suggested to constitute determinants of CD. Mutations of NOD2/CARD15
or TLR-4, however, do not lead to permeability defects emphasizing the importance
of additional environmental and/or genetic factors for pathogenesis.
PMID: 16393227 [PubMed - indexed for MEDLINE
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Cytomegalovirus disappearance after treatment for refractory ulcerative colitis in 2 patients treated with infliximab and 1 patient with leukapheresis
No full textVariations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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