1,721,098 research outputs found
Regulatory mutations in transforming growth factor-β3 gene involved in arrhythmogenic right ventricular cardiomyopathy
No full textSteel like Straw : Louis I. Kahn and the Indian Institute of Management in Ahmedabad
No full textDesigned by Louis I. Kahn in Ahmedabad between 1962 and 1974, the Indian Institute of Management (IIM) is considered to be one of his mature works and one of the most monumental buildings he conceived.
Initially involved only as a consultant, this project challenged him with new and unparalleled questions concerning the management of a “remote” construction site in a country where he was not familiar with tradition and methods such as India in the aftermath of its independence (1947). The reconstruction in detail of the multifaceted events of the design of the architectural complex, made it possible to highlight the significance that the IIM assumed within the broader cultural policy initiated by the Indian government and the different roles played by the protagonists involved. In particular, it retraced the working method developed by Kahn, underlining his obsessive attention to the construction details which define the overall shape of the buildings that were left with no cladding. The IIM’s focus on the various phases has also become a matter of urgency in recent years, since only a few years after the completion of the construction site the walls have begun to show the first signs of degradation which remain unsolved still today
Steel like straw. The Case of the Indian Institute of Management in Ahmedabad designed by Louis I. Kahn
No full textThe International Conference “Modern Heritage between Care and Risk” (Venice, 4-5th May 2021) was held at Università Iuav di Venezia, in collaboration with Fondation Le Corbusier and Docomomo Italia. The event offered an opportunity for an international exchange on crucial issues of documentation and preservation of the 20th century architectural heritage in a time of rapid social, cultural and political changes. The first day has been dedicated to “Ahmedabad. Laboratory of Modern Architecture”, a site-manifesto threatened today by the demolition of relevant dormitories of the Indian Institute of Management by Louis I. Kahn. The second day has been dedicated to “Living the Architectural Preservation. Modern Houses in the Conservation of 20th Century Heritage”, focused on recent conservation/restoration works of Modern authorial houses and neighbourhoods. The proceedings collect selected papers presented by international researchers and architects involved in the fields of History of Architecture and Architectural Preservation
La lezione di Venezia : come imparare dal contesto nel caso della Casa alle Zattere di Ignazio Gardella
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Acciaio come paglia, Louis I. Kahn : il caso dell'Indian Institute of Management di Ahmedabad
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Genetic bases of arrhythmogenic right ventricular cardiomyopathy
No full textArrhythmogenic right ventricular cardiomyopathy (ARVC) is a heart muscle disease in which the pathological substrate is a fibro-fatty replacement of the right ventricular myocardium. The major clinical features are different types of arrhythmias with a left branch block pattern. ARVC shows autosomal dominant inheritance with incomplete penetrance. Recessive forms were also described, although in association with skin disorders. Ten genetic loci have been discovered so far and mutations were reported in five different genes. ARVD1 was associated with regulatory mutations of transforming growth factor beta-3 (TGFβ3), whereas ARVD2, characterized by effort-induced polymorphic arrhythmias, was associated with mutations in cardiac ryanodine receptor-2 (RYR2). All other mutations identified to date have been detected in genes encoding desmosomal proteins: plakoglobin (JUP) which causes Naxos disease (a recessive form of ARVC associated with palmoplantar keratosis and woolly hair); desmoplakin (DSP) which causes the autosomal dominant ARVD8 and plakophilin-2 (PKP2) involved in ARVD9. Desmosomes are important cell-to-cell adhesion junctions predominantly found in epidermis and heart; they are believed to couple cytoskeletal elements to plasma membrane in cell-to-cell or cell-to-substrate adhesions
Conservation Plans for Modern Architecture: The Case of IIM. : A conversation with Brinda Somaya
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