86,591 research outputs found
Histoire du Commerce de Marseille, publiée par la Chambre de Commerce de Marseille sous la direction de G. Rambert, Directeur de l’École supérieure de commerce. Tome IV. De 1599 à 1660 par L. Bergasse ; De 1660 à 1789 par G. Rambert. Paris, Plon, 1954
No full textLanversin F. de. Histoire du Commerce de Marseille, publiée par la Chambre de Commerce de Marseille sous la direction de G. Rambert, Directeur de l’École supérieure de commerce. Tome IV. De 1599 à 1660 par L. Bergasse ; De 1660 à 1789 par G. Rambert. Paris, Plon, 1954. In: Mélanges de l'Université Saint-Joseph, tome 31, 1954. pp. 383-384
Histoire du Commerce de Marseille publiée par la Chambre de Commerce de Marseille, sous la direction de G. Rambert. Tome II, de 1291 à 1490. Par Éd. Baratier et F. Raynaud. Paris, Plon, 1951
No full textLanversin F. de. Histoire du Commerce de Marseille publiée par la Chambre de Commerce de Marseille, sous la direction de G. Rambert. Tome II, de 1291 à 1490. Par Éd. Baratier et F. Raynaud. Paris, Plon, 1951. In: Mélanges de l'Université Saint-Joseph, tome 29, 1951. pp. 346-347
A. Baud, G. Cornu, M. Martiniani-Reber, J.-M. Poisson, J.-F. Reynaud & C. Treffort, Saint-Rambert. Un culte régional depuis l'époque mérovingienne. Histoire et archéologie
No full textMasset Claude. A. Baud, G. Cornu, M. Martiniani-Reber, J.-M. Poisson, J.-F. Reynaud & C. Treffort, Saint-Rambert. Un culte régional depuis l'époque mérovingienne. Histoire et archéologie. In: L'Homme, 1996, tome 36 n°139. p. 187
Histoire du commerce de Marseille, VI, De 1860 à 1789. Les colonies, par G. Rambert. Paris, Plon, 1959. — Histoire du commerce de Marseille, Index des t. I, II, ΙII, IV. Plon, 1956
No full textLanversin F. de. Histoire du commerce de Marseille, VI, De 1860 à 1789. Les colonies, par G. Rambert. Paris, Plon, 1959. — Histoire du commerce de Marseille, Index des t. I, II, ΙII, IV. Plon, 1956. In: Mélanges de l'Université Saint-Joseph, tome 36, 1959. pp. 255-256
Differential enhancement of dialysate serotonin levels in distinct brain regions of the awake rat by modafinil: Possible relevance for wakefulness and depression
No full textThe present in vivo microdialysis study evaluates the possible existence of a differential regulation of serotonergic transmission by the antinarcoleptic drug modafinil [(diphenyl-methyl)-sulfinyl-2-acetamide; Modiodal] among various brain regions of the awake rat. The results show that, in the cerebral cortex, the central amygdala, and the dorsal raphe nucleus, modafinil in the dose range of 10-100 mg/kg i.p. dose-dependently increases dialysate serotonin (5-HT) levels. In other brain areas, such as the medial preoptic area and the posterior hypothalamus, the modafinil-induced increase in dialysate 5-HT levels is observed only at tenfold higher doses (100 mg/kg), 10-30 mg/kg being ineffective. Together these data suggest that, in the frontal cortex, the amygdala, and the dorsal raphe, modafinil is more potent in enhancing extracellular 5-HT levels and presumably 5-HT transmission than in the medial preoptic area and the posterior hypothalamus. In view of the role of ascending 5-HT pathways in arousal and depression, it seems likely that the antinarcoleptic drug modafinil may also have an antidepressant potential in addition to its wakefulness-promoting action, both actions involving enhancement of 5-HT neurotransmission
Amplification of cortical serotonin release: a further neurochemical action of the vigilance-promoting drug modafinil
No full textThe present in vitro and in vivo studies examined the effects of modafinil on serotonergic transmission in the rat frontal cortex. In the in vitro study modafinil (0.3-30 microM) increased electrically-evoked, but not spontaneous, serotonin ([(3)H]5-HT) efflux from cortical slices in a concentration-dependent manner while the indirect serotonin agonist dl-fenfluramine (1-15 microM) enhanced both spontaneous and evoked [(3)H]5-HT efflux. The effects of modafinil were more pronounced when the 5-HT reuptake was blocked by paroxetine. Contrary to paroxetine (0.3-3 microM) and dl-fenfluramine (1-5 microM), modafinil failed to influence the [(3)H]5-HT uptake. In the in vivo study modafinil (3-100 mg/kg i.p.) increased 5-HT dialysate levels, the maximal effect being already reached at the 30 mg/kg dose. dl-fenfluramine (5 mg/kg) induced an increase in 5-HT levels which was significantly higher than that displayed by modafinil at 30 mg/kg. In the presence of paroxetine (3 microM), the effect of modafinil at 30 mg/kg was higher than that observed in the absence of 5-HT reuptake inhibition. Finally, in the presence of the selective 5-HT(1A) receptor agonist 8-OH-DPAT, modafinil at 100 mg/kg failed to affect 5-HT dialysate levels. These results demonstrate that modafinil regulates cortical serotonergic transmission and suggest that the drug preferentially acts by amplifying the electro-neurosecretory coupling mechanisms and via mechanisms which do not involve the reuptake process
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