601 research outputs found
Why are Wischnewski spots not always present in lethal hypothermia? The results of testing a stress-reduced animal model
No full textHypothermic fatalities in humans are characterized by a range of often subtle pathological findings that typically include superficial erosive gastritis (Wischnewski spots). Experimental studies have been successfully performed using animal models to replicate this finding, however study animals have inevitably been subjected to a variety of additional stressors including food deprivation, restraint and partial immersion in water while conscious. As it is recognised that stress on its own may cause superficial erosive gastritis, a model has been developed to enable the study of the effects of hypothermia in isolation. 42 Sprague-Dawley rats were allowed free social contact and were fed and watered ad libitum prior to being anaesthetized with isoflurane. Once unconscious, rats were placed on drape cloth covering metal mesh platforms in a styrofoam box packed with ice. The apparatus enabled both maintenance of a specific low temperature (26 °C) in 14 animals, and continued reduction of core temperatures in the remaining 28 (who all died of hypothermia under anaesthesia). Examination of the gastric mucosa in both groups macroscopically and microscopically failed to demonstrate typical Wischnewski spots in any of the 42 animals. Thus, in this model, death from hypothermia occurred without the development of these lesions. These results suggest that stress may be a significant effect modifier in the development of Wischnewski spots in lethal hypothermia.Fiona Bright, Calle Winskog, Melissa Walker, Roger W. Byar
Integrating Inhomogeneous Processing and Proto-object Formation in a Computational Model of Visual Attention
No full textWischnewski M, Steil JJ, Kehrer L, Schneider WX. Integrating Inhomogeneous Processing and Proto-object Formation in a Computational Model of Visual Attention. In: Ritter H, Sagerer G, Dillmann R, Buss M, eds. Human Centered Robot Systems: Cognition, Interaction, Technology. Cognitive Systems Monographs, 6. 2009: 93-102
Collaborazione scientifica
No full textCollaborazione scientifica nell'ambito del progetto europeo KM3NeT.
Il programma di lavoro al quale il Dott. Wischnewski ha collaborerà era inserito nell'attività del Work Package 5 del progetto finanziato dalla comunità economica europea (VI programma quadro) denominato KM3NeT-Design Study. In particolare il Dr. Wischnewski ha collaborato a
- studio delle proprietà ambientali dei siti del Mediterraneo abissali;
- stima dell'assorbimento, diffusione, attenuazione in acqua della luce Cherenkov prodotta dalla propagazione di particelle relativistiche in acqua;
- studio dell'effetto delle proprietà ottiche dell'acqua marina abissale sulle proprietà di un Telescopio per Neutrini;
- confronto fra le proprietà abissali del Mediterraneo e quelle di Baikal ed IceCube, loro effetto sulle proprietà del Telescopio per Neutrini.
Il Dott. Wischnewski per l’esperienza acquisita durante il lavoro di ricerca per BAIKAL, AMANDA ed IceCube è stato il collaboratore ideale per il lavoro su descritto
CpG-island promoters drive transcription of human telomeres
No full textThe longstanding dogma that telomeres, the heterochromatic extremities of linear eukaryotic chromosomes, are transcriptionally silent was overturned by the discovery that DNA-dependent RNA polymerase II (RNAPII) transcribes telomeric DNA into telomeric repeat-containing RNA (TERRA). Here, we show that CpG dinucleotide-rich DNA islands, shared among multiple human chromosome ends, promote transcription of TERRA molecules. TERRA promoters sustain cellular expression of reporter genes, are located immediately upstream of TERRA transcription start sites, and are bound by active RNAPII in vivo. Finally, the identified promoter CpG dinucleotides are methylated in vivo, and cytosine methylation negatively regulates TERRA abundance. The existence of subtelomeric promoters, driving TERRA transcription from independent chromosome ends, supports the idea that TERRA exerts fundamental functions in the context of telomere biology
Neurophysiological and behavioral effects of oscillatory transcranial direct current stimulation (otDCS)
No full texthttp://dx.doi.org/10.13039/501100001655 German Academic Exchange Servicehttp://dx.doi.org/10.13039/501100004564 Republic of Serbia Ministry of Education Science and Technological Developmenthttp://dx.doi.org/10.13039/501100003246 Nederlandse Organisatie voor Wetenschappelijk Onderzoekhttp://dx.doi.org/10.13039/501100000780 European Commissionhttp://dx.doi.org/10.13039/501100001659 Deutsche Forschungsgemeinschafthttp://dx.doi.org/10.13039/501100002347 Bundesministerium für Forschung, Technologie und Raumfahrthttp://dx.doi.org/10.13039/100010661 Horizon 2020 Framework Programmehttp://dx.doi.org/10.13039/100018693 Horizon 202
Untersuchungen zur Wassergasbildung bei Störfaellen an HTR-Reaktoren am Beispiel einer geplanten Heissgastemperaturerhöhung auf 950°C am AVR-Reaktor
No full textFactors influencing credibility perceptions of AI journalism: Investigating attitudes, trust in news media, and perceived agency
No full textThis bachelor thesis addresses factors influencing the perceived credibility of AI-generated articles in journalism. Specifically, the influence of media trust, agency, the machine heuristic, and the author on perceived (message) credibility will be investigated
The Raman coupling function in amorphous silica and the nature of the long wavelength excitations in disordered systems
No full textNew Raman and incoherent neutron scattering data at various temperatures and
molecular-dynamic simulations in amorphous silica are compared to obtain the Raman coupling
coefficient C(omega) and, in particular, its low-frequency limit. This study indicates that in the omega --> 0 limit C(omega) extrapolates to a non vanishing value, giving important indications on the
characteristics of the vibrational modes in disordered materials; in particular our results indicate
that even in the limit of very long wavelength the local disorder implies non regular local atomic
displacements
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