1,439 research outputs found
A duality result for almost split sequences
No full textOver an artinian hereditary ring R, we discuss how the existence of almost split sequences starting at the indecomposable non-injective preprojective right R-modules is related to the existence of almost split sequences ending at the indecomposable non-projective preinjective left R-modules. This answers a question raised by Simson in [27] in connection with pure semisimple rings
Bip 1, a monoclonal antibody with specificity for the major birch pollen allergen Bet v 1, modulates IgE binding to the allergen
No full textno abstrac
Financial Analysis of Company Valenta ZT s.r.o.
No full textCílem mé práce je zhodnotit finanční zdraví výrobního podniku Valenta ZT s. r. o. Za pomocí veřejně dostupných zdrojů provedu finanční analýzu, která bude přínosná nejen pro vedení společnosti, případně i pro subjekty s ní spojené. Analýza bude provedena v období 2011-2015. Práce je rozdělena na část teoretickou a část praktickou. V teoretické části popíši problematiku a nástroje finanční analýzy. V části praktické představím analyzovanou společnost, dále pak odvětví, ve kterém se podnik nachází a zpracuji finanční analýzu. Na závěr jednotlivé výstupy ohodnotím a navrhnu případná opatření.The target of this bachelor thesis is to evaluate the financial health of manufacturing company Valenta ZT s.r.o. I shall do a financial analysis while using publicly available sources and documents. This analysis should be useful not only for the company itself, but also for other subjects connected with it. The analysis covers the period between years 2011 and 2015. The thesis consists of two parts. The first part, theoretical, will describe the matters and tools of financial analysis. Second, practical part, shall present the company and also the field in which the company operates. Financial analysis will also be presented in this second part. At the end of this thesis I shall evaluate the outcome of the analy-sis and propose few possible steps for the company
The immunoglobulin-like modules Cε3 and α2 are the minimal units necessary for human IgE-FcεRI interaction
No full textAtopic allergy is a genetically determined immunodisorder that affects almost 20% of the population worldwide. Immediate symptoms of type I allergy are caused by the release of biologic mediators from effector cells induced by IgE-allergen complexes that cross-link the high-affinity receptor for IgE (FcepsilonRI). Chronic disease manifestations result from allergen-specific T-cell activation, a process that is enhanced when allergens are presented via FcepsilonRI-bound IgE. We report the baculovirus expression, as soluble recombinant proteins, of the minimal units required for human IgE and FcepsilonRI interaction: Cepsilon3 represents the third constant domain of the IgE heavy chain, and alpha2 is the membrane-proximal Ig-like module from FcepsilonRIalpha. Native overlay experiments showed binding of human FcepsilonRIalpha to recombinant Cepsilon3 and of natural or recombinant human IgE to recombinant alpha2. Moreover, recombinant Cepsilon3 inhibited binding of natural IgE antibodies to alpha2, and preincubation of human IgE with alpha2 inhibited anti-IgE-triggered histamine release from human basophils. Isolated Cepsilon3 and alpha2 can now be used for the molecular and structural analysis of the IgE-FcepsilonRI interaction, as well as for diagnostic and therapeutic applications
Brunski, Jan Jacek - Maur, Eduard - Pulaski, Michal - Valenta, Jaroslav (eds.): Mezi dvěma transformacemi. Československo a Polsko v letech 1947 (1948) - 1989.: MŠMT ČR + FF UK, Praha 2001. 237 s. ISBN 80-7308-01 5-X.
No full textA review of the book by Jan Jacek Brunski, Eduard Maur, Michal Pulaski and Jaroslav Valenta
Rev. Marcus A. Valenta, pastor of St. Francesco di Paula Church, addressing the crowd during riot in Municipal Auditorium, San Antonio, Texas, 1939
No full textPicture caption for related photo (L-2222-R): ''Father M. A. Valenta shown as he spoke to crowd announcing meeting was over. Father Valenta later led a crowd of 2000 or more to Alamo where Lord's prayer was said.''''San Antonio Saturday surveyed the havoc wrought in the greatest exhibition of mob violence and vandalism in the city's history--caused by a meeting of a handful of Communists in the Municipal Auditorium. In the wake of the mass hysteria participated in by a crowd of 10,000 Friday night, were 17 identified injured....The demonstration, brought on when veterans' and other organizations condemned action of the city in granting a permit to the Communist party for a rally in a structure dedicated as a war memorial, was led by teenage youths and a sprinkling of veterans....Father Valenta, seeking to disperse the angry mob, mounted to a balcony in the front part of the building and began pleading with the crowd....Failing in this attempt, he went to the front of the building and led the mob inside as a door at the main entrance was broken open....''(August 26) ; ''....Prominent in the affair at the auditorium Friday night were: The Rev. Marcus A. Valenta, Catholic pastor and secretary of the archdiocese, who led the rioters in a parade through the downtown district and in prayers before the Alamo....''(August 27
HIV-specific antibody responses in HIV-infected patients: From a monoclonal to a polyclonal view
No full textHIV infections represent a major global health threat, affecting more than 35 million individuals worldwide. High infection rates and problems associated with lifelong antiretroviral treatment emphasize the need for the development of prophylactic and therapeutic immune intervention strategies. It is conceivable that insights for the design of new immunogens capable of eliciting protective immune responses may come from the analysis of HIV-specific antibody responses in infected patients. Using sophisticated technologies, several monoclonal neutralizing antibodies were isolated from HIV-infected individuals. However, the majority of polyclonal antibody responses found in infected patients are nonneutralizing. Comprehensive analyses of the molecular targets of HIV-specific antibody responses identified that during natural infection antibodies are mainly misdirected towards gp120 epitopes outside of the CD4-binding site and against regions and proteins that are not exposed on the surface of the virus. We therefore argue that vaccines aiming to induce protective responses should include engineered immunogens, which are capable of focusing the immune response towards protective epitopes
Natural rubber latex and hymenoptera venoms share immunoglobinE-epitopes accounting for cross-reactive carbohydrate determinants
No full textBackground Epidemiological data on the prevalence and risk factors of latex sensitization have suggested a significant association between latex sensitization and the presence of one or more positive skin prick test responses to aeroallergens, food allergens and to one or more insect venoms. Xylose and core 3-fucose are typical complex glycans in plants and are foreign to mammals. Plant N-glycans and insect N-glycans may cross-react in humans. Objective The aim of our study was to investigate whether there are cross-reactive IgE-binding structures in natural rubber latex (NRL) and hymenoptera venoms and to examine their nature. Methods Hundred and twenty-five consecutive patients with insect venom allergy were screened for coincidental latex-specific IgE. IgE-binding components in the venoms from Apis mellifera and/or vespula species and in NRL extracts were characterized by IgE-immunoblotting to the natural allergen sources and determination of specific IgE to recombinant allergens. Cross-reactive components were investigated by inhibition experiments. The involvement of carbohydrates in the constitution of cross-reactive IgE-epitopes was further examined by specific IgE-binding to cross-reactive carbohydrate determinants (CCD) in bromelain and horseradish peroxidase as well as by periodate treatment. Results NRL glove extracts inhibited patients' serum IgE-binding to venom allergens. Vice versa, the IgE-binding to latex glove extracts could be inhibited by pre-incubation with the insect venoms. Specific IgE-binding to recombinant latex allergens was absent, whereas the cross-reactive IgE-epitopes were sensitive to periodate treatment and specific IgE to CCD (MMXF and MUXF type) could be detected. Conclusion Insect venoms and NRL share IgE-binding CCD that may be responsible for positive serological test results to NRL in patients with insect venom allergy. This copositivity occurs frequently (13.6%) among venom-allergic individuals and did not elicit clinical symptoms upon contact to latex in the patients examined. In contrast, true cosensitization to insect venoms and NRL allergens can occur and may not be missed
Diagnostic Value of PET-Measured Longitudinal Flow Gradient for the Identification of Coronary Artery Disease
No full textObjectivesThe purpose of this study was to evaluate the diagnostic value of a positron emission tomography (PET)/computed tomography (CT)–determined longitudinal decrease in myocardial blood flow (MBF) gradient during hyperemia and myocardial flow reserve (MFR) for the identification of epicardial stenosis ≥50%.BackgroundAlthough PET-determined reductions in MFR are increasingly applied to identify epicardial lesions in coronary artery disease (CAD), it may be seen as a suboptimal approach due to the nonspecific origin of decreases in MFR.MethodsIn 24 patients with suspected or known CAD, MBF was measured with 13N-ammonia and PET/CT in ml/g/min at rest, during dipyridamole stimulation, and the corresponding MFR was calculated. MBF was also determined in the mid and mid-distal myocardium of the left ventricle (LV). A decrease in MBF from mid to mid-distal LV myocardium was defined as longitudinal MBF gradient. MBF parameters were determined in the myocardial region with stress-induced perfusion defect and with stenosis ≥50% (territory 1), without defect but with stenosis ≥50% (territory 2), or without stenosis ≥50% (territory 3).ResultsIn territories 1 and 2 with focal stenosis ≥50%, the severity of epicardial artery stenosis correlated with the Δlongitudinal MBF gradient (stress-rest) (r = 0.52; p < 0.0001), while this association was less pronounced for corresponding MFR (r = −0.40; p < 0.003). On a vessel-based analysis, the sensitivity and specificity of the Δlongitudinal MBF gradient in the identification of epicardial lesions was higher than those for MFR (88% vs. 71%, p ≤ 0.044; and 81% vs. 63%, p = 0.134, respectively). Combining both parameters resulted in an optimal sensitivity of 100% and intermediate specificity of 75%. The diagnostic accuracy was highest for the combined analysis than for the Δlongitudinal MBF gradient or MFR alone (94% vs. 86%, p ≤ 0.003; and 94% vs. 70%, p ≤ 0.0002).ConclusionsThe combined evaluation of a Δlongitudinal MBF gradient and MFR may evolve as a new promising analytic approach to further optimize the identification of CAD lesions
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