2,050 research outputs found
Utili (art. 2262 c.c.)
No full textSi tratta del commento all'art. 2262 c.c. ovvero alla norma che disciplina la percezione degli utili nelle società di person
Ameliorating effect of tauroursodeoxycholate (TUDC) but not taurocholate (TC) on chlorpromazine (CPZ) cholestasis.
No full textMolecular epidemiology of Streptococcus bovis causing endocarditis and bacteraemia in Italian patients.
No full textStreptococcus bovis is being recognised increasingly as a cause of infective
endocarditis, and has also been associated with underlying gastrointestinal
malignancy. This study evaluated the molecular epidemiology of S. bovis isolates
responsible for endocarditis or bacteraemia in Italian patients between January
1990 and August 2003. S. bovis isolates were classified on the basis of their
biochemical profiles, antimicrobial susceptibilities and genotypes. Of 25
isolates studied, 20 were S. bovis I and five were S. bovis II. Seven biochemical
profiles were identified. Pulsed-field gel electrophoresis (PFGE) analysis
identified 22 profiles that differed by at least two DNA fragments and showed a
similarity of < 87%. Most PFGE patterns represented single isolates that differed
in antimicrobial susceptibility, but three PFGE types were observed, with
identical profiles and antibiotypes, in isolates from two different patients. S.
bovis I and II isolates grouped into two distinct genetic clusters (I and II)
with a similarity coefficient of 38%. Two sub-clusters (Ia and Ib), with a
similarity coefficient of 47%, included 17 S. bovis I isolates with similar
biochemical profiles (15 with biotype A, and two with biotype B), but different
resistance phenotypes. Based on the phenotypic and genotypic heterogeneity of the
isolates, it is postulated that the increase in S. bovis endocarditis in this
geographical area might have been caused by the selection of sporadic endemic
clones from the endogenous intestinal
DEM analysis of bonded granular geomaterials
No full textIn this paper, the application of the distinct element method (DEM) to frictional cohesive (c, ϕ) geomaterials is described. A new contact bond model based on the Mohr–Coulomb failure criterion has been implemented in PFC2D. According to this model, the bond strength can be clearly divided into two distinct micromechanical contributions: an intergranular friction angle and a cohesive bond force. A parametric analysis, based on several biaxial tests, has been run to validate the proposed model and to calibrate the micromechanical parameters. Simple relationships between the macromechanical strength parameters (c, ϕ) and the corresponding micromechanical quantities have been obtained so that they can be used to model boundary value problems with the DEM without need of further calibration.
As an example application, the evolution of natural cliffs subject to weathering has been studied. Different weathering scenarios have been considered for an initially vertical cliff. Firstly, the case of uniform weathering has been studied. Although unrealistic, this case has been considered in order to validate the DEM approach by comparison against analytical predictions available from limit analysis. Secondly, non-uniform weathering has been studied. The results obtained clearly show that with the DEM it is possible to realistically model boundary value problems of bonded geomaterials, which would be overwhelmingly difficult to do with other numerical techniques
Combination therapy in severe Acinetobacter baumannii infections: an update on the evidence to date.
No full textAcinetobacter baumannii is a drug-resistant Gram-negative pathogen increasingly causing hospital-acquired infections in critically ill patients. In this review, we summarize the current mechanisms of antimicrobial resistance in A. baumannii and describe in detail recent in vitro and in vivo experimental data on the activity of antimicrobial
combinations against this microorganism. We then introduce the rationale for the use of combination antibiotic therapy in resistant A. baumannii infections. Finally, we present and critically discuss both uncontrolled clinical studies and the few randomized clinical trials
of combination antimicrobial therapy for these infections, with a special focus on ongoing multinational trials and optimal approach to future research in this field
FIMEC indentation test for the mechanical characterization of steels and other alloys of MATTER interest
No full text
Steatosis accelerates the progression of liver damage of chronic hepatitis C patients and correlates with specific HCV genotype and visceral obesity.
No full textThe role of steatosis in the progression of liver damage in chronic hepatitis C (CHC) was studied. Enrolled were 180 consecutive liver biopsy-proven CHC patients and 41 additional subjects with a known duration of infection. We evaluated the histological activity index (HAI), grade of fibrosis and steatosis, body mass index (BMI; kg/m(2)), distribution of body fat, HCV genotype, and levels of HCV-RNA. Eighty six (48%) patients showed steatosis, and a higher prevalence was observed in genotype 3a infection (P 30%) showed higher serum levels of
gamma-GT and ALT (P <.001). Overall, steatosis was not significantly associated to BMI. Analysis by single genotype showed a significant association between the grade of steatosis and BMI in type 1 infection r =.689; P <.001) and with levels
of HCV RNA in type 3a infection r =.786; P <.001). Visceral fat distribution rather than BMI proved to be associated with steatosis (P <.001). Data obtained from patients with a known date of infection confirmed that steatosis grades 3-4 were associated with a higher annual rate of fibrosis progression, and showed
that alcohol and steatosis act together in increasing fibrosis (P <.05). Our data ndicate that steatosis is an important cofactor in increasing liver necroinflammatory activity and in accelerating fibrosis in CHC. Visceral obesity and genotype 3a play a role in the development of steatosis
On the optimal profile of a slope
No full textThe problem of determining the best profile for a c, φ soil slope is tackled, with reference to rigid rotational failure mechanisms. By means of limit analysis, upper bound values of collapse load are determined. A new mathematical function is derived to compute the external work made by the weight of a double spiral shaped soil region sliding away. It is found that a log spiral front is associated with a larger safety factor than a planar one. The obtained results may also explain the log-spiral shape of perimeter walls of some typical Japanese castles
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