1,671 research outputs found
Comprehensive schools and traditional education in the Federal Republic of Germany
No full textTillmann K-J. Comprehensive schools and traditional education in the Federal Republic of Germany. International journal of educational research. 1988;12(5):471-480.This article first presents some general information on the traditional tripartite system of education in Germany: Hauptschule, Realschule, Gymnasium. It describes the changes this system has undergone since the 1960s: because of the increased demand for schooling offering higher qualification certificates, the Hauptschule has declined in image and importance. The following passage shows both the political and social reasons that led to an experimental phase of the integrated comprehensive schools in all of the eleven states at the end of the 1960s. The integrated comprehensive school was not able to supersede the tripartite school system in the development of educational policies but only managed to be accepted as a fourth possibility. In the course of the experimental phase a wide, decentralized evaluation research programme was carried out. The most important results - horizontal mobility, equality of educational opportunity, school climate, academic achievement - are mentioned in context. The findings of the evaluation research programme do not provide any proof of the political failure of the educational reform in favour of a comprehensive system
Structure-based design of artificial metalloenzymes and beyond
No full textOptically active molecules play a fundamental role in the functions of live. The enantioselective synthesis of chiral building blocks is crucial for the production of high value compounds such as pharmaceuticals or pesticides. Besides homogenous transition metal and enzymatic catalysts, artificial metalloenzymes - that consist of metal cofactors anchored within protein scaffolds - have been developed in the past decade to access optically pure compounds. The creation and optimization of these hybrid systems requires structural information. The asymmetric transfer hydrogenation of functional carbonyl, imine or enone groups to obtain the corresponding alcohols, amines or alkanes in high optical purity is achieved by transition metal piano stool complexes as well as by a number of different enzymes. In this thesis, two artificial transfer hydrogenases based on the streptavidin-biotin system for the asymmetric reduction of cyclic imines are structurally characterized. Potential substrate binding modes are proposed and the origins of the enantioselectivities are discussed. The Sharpless osmium-catalyzed asymmetric dihydroxylation of olefins is a powerful method to obtain chiral vicinal diols from variously substituted substrate molecules. The enantioselectivity of the reaction is governed by the interactions between the substrate olefins and the bulky chiral ligands bound to the catalytic osmium tetroxide center. In this thesis, an artificial olefin dihydroxylase is structurally characterized which is based on the embedding of an osmium tetroxide catalyst within streptavidin. Although none of the four osmium-binding sites located in the crystal structures was bound to the biotin-binding pocket, the activity pattern of various streptavidin mutants suggests that the active site is located in proximity to this position. During the processing of the diffraction data of one of the streptavidin-osmium crystals, an ambiguous packing disorder was diagnosed for which a quantitative model is proposed in the final chapter of this thesis.
Human carbonic anhydrase II is a well-characterized monomeric protein and numerous arylsulfonamide inhibitors with nanomolar and subnanomolar affinities for this enzyme are described in the literature. The potential of this protein to act as a host for the creation of an artificial transfer hydrogenase is evaluated by the structural characterization of an arylsulfonamide-tethered transition metal piano stool complex bound to human carbonic anhydrase II. This study is also investigating the structural origins of the high affinities of piano stool arylsulfonamide complexes for human carbonic anhydrase II and the implications for future metallodrug design.
A number of ruthenium-arene piano stool complexes have been demonstrated to strongly inhibit the growth of human cancer cell lines by unspecific interactions with nucleobases. To introduce DNA-specificity via second coordination sphere interactions, two ruthenium arene complexes have been biotinylated and bound to streptavidin. The structural basis of the DNA-specificity governed by the streptavidin-ruthenium arene complex is investigated.
The in vivo activity of artificial metalloenzymes is a prerequisite for their genetic optimization by directed evolution. Moreover, hybrid enzymes have the potential to be used in vivo to complement metabolic pathways or to act as bioorthogonal catalyst in the activation of prodrugs. The strategy of enzyme-encapsulation into cell-penetrating nanoreactors is investigated which allows the shuttling of artificial metalloenzymes into cells
Fritz Tillmann, Die sonntäglichen Episteln, tm Dienste der Predigt erklärt, 1950
No full textR. C. Fritz Tillmann, Die sonntäglichen Episteln, tm Dienste der Predigt erklärt, 1950. In: Revue des Sciences Religieuses, tome 27, fascicule 2, 1953. p. 206
Gemeinsam eine lokale Antibiotika-Verordnungskultur schaffen - das Praxisbeispiel des Projektes AnTiB
No full textHartmann J, Tillmann R, Leeuw B, Bornemann R. Gemeinsam eine lokale Antibiotika-Verordnungskultur schaffen – das Praxisbeispiel des Projektes AnTiB . In: 53. Kongress für Allgemeinmedizin und Familienmedizin (DEGAM-Kongress). Düsseldorf: German Medical Science GMS Publishing House; 2019.Hintergrund: In der ambulanten Medizin bestehen große regionale Unterschiede bei Antibiotika-(AB-)Verordnungen. Diese können nur zum Teil medizinisch erklärt werden. Das Verordnungsverhalten wird maßgeblich durch „lokale kulturelle unausgesprochene Regeln“ mitbeeinflusst.[zum vollständigen Text gelangen Sie über die oben angegebene URL
The Influence of Social Information on Norms of Cooperation [research data PhD project]
No full textReplication package for the dissertation titled "The Influence of Social Information on Norms of Cooperation" by Tillmann Eymess, Heidelberg University.
The package includes all replication files for the individual chapters of the dissertation as well as supplementary material. Provided are .csv files with the minimal data sets necessary to replicate all results, as well as scripts (for Stata and R), and readme files
Integration und Differenzierung: Überwindung des gegliederten Schulsystems
No full textTillmann K-J. Integration und Differenzierung: Überwindung des gegliederten Schulsystems. In: Oberliesen R, ed. Schule Ost - Schule West: ein deutsch-deutscher Reformdialog. Reihe: Forschung Pädagogik. Vol 2. Hamburg: Bergmann und Helbig; 1992: 135-145
Was leistet die PISA-Studie zur Steuerung des Bildungssystems?
No full textTillmann K-J. Was leistet die PISA-Studie zur Steuerung des Bildungssystems? In: Tippelt R, ed. Steuerung durch Indikatoren. Vorstandsreihe der Deutschen Gesellschaft für Erziehungswissenschaft. Opladen: Barbara Budrich; 2009: 17-30
The wrong trousers? Common folk in striped clothes as readers of early modern recipes.
No full textBy Tillmann Taape When trying to make historical sense of printed medical recipe collections, one tricky but important question always recurs: who did the author and/or publisher think would be likely to read and benefit from their books? In my own research, which focuses on the works of the surgeon-apothecary Hieronymus Brunschwig (introduced here and here), this question is particularly intriguing because these books were among the first medical books to be printed in German. Of course, li..
Datenreport Erziehungswissenschaft 2008
No full textTillmann K-J, Rauschenbach T, Tippelt R, Weishaupt H, eds. Datenreport Erziehungswissenschaft 2008. Schriften der Deutschen Gesellschaft für Erziehungswissenschaft (DGfE). Opladen: Barbara Budrich; 2008
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