3,514 research outputs found
Haasia cornuata Strasser 1940
No full textNew data for Haasia cornuata (Strasser, 1940) SLOVENIA: 1 ♂, 1 juvenile, Veliki Mižuk Pit, Mokri Potok, 15 Dec. 2015, leg. T. Delić & S. Polak (IZB).Published as part of Dragan Ž. Antić, Tvrtko Dražina, Tonći Rađa, Luka R. Lučić & Slobodan E. Makarov, 2016, Taxonomic status of the family Biokoviellidae Mršić, 1992 (Diplopoda, Chordeumatida): reconsideration, with a description of one new species, pp. 1-23 in European Journal of Taxonomy 205 on page 18, DOI: 10.5852/ejt.2016.205, http://zenodo.org/record/26927
Typhloiulus longinquus Strasser 1965
No full textTyphloiulus longinquus Strasser, 1965 Typhloiulus (Typhloiulus) longinquus Strasser, 1965 Typhloiulus longinquus: Minelli 1982 Material. 1 ♂ (ZMUC), Italy: Lettomanopello (PE), cave Praie (type locality!), 16.VII. 1982, Antonucci leg., R. Pisoni ded. 1989. Descriptive notes. Ozopores placed behind suture at ca 1 / 3 of metazonal length. Preanal process stout, turned somewhat downwards. Subanal scale short and rounded. Male legs in anterior part of body with a very small, weakly pronounced adhesive pad on tibia, with a pit on postfemur. Distribution. Known only from the type locality: Italy: cave Praie, S of Lettomanoppello.Published as part of Vagalinski, Boyan, Stoev, Pavel & Enghoff, Henrik, 2015, A review of the millipede genus Typhloiulus Latzel, 1884 (Diplopoda: Julida: Julidae), with a description of three new species from Bulgaria and Greece, pp. 334-362 in Zootaxa 3999 (3) on page 342, DOI: 10.11646/zootaxa.3999.3.2, http://zenodo.org/record/23401
Abb. 1 in Wiederentdeckung der verschollenen Wasserschneckenarten Anisus vortex (LINNAEUS 1758) und Ferrissia wautieri (MIROLLI 1960) in Salzburg (Gastropoda, Planorbidae)
No full textAbb. 1: Anisus vortex aus der Stadt Salzburg. Rasterelektronenmikroskopische Aufnahme.Published as part of Strasser, T., Travnitzky, R. & R.A, 2006, Wiederentdeckung der verschollenen Wasserschneckenarten Anisus vortex (LINNAEUS 1758) und Ferrissia wautieri (MIROLLI 1960) in Salzburg (Gastropoda, Planorbidae), pp. 903-906 in Linzer biologische Beiträge 30 (1) on page 904, DOI: 10.5281/zenodo.543443
Darstellung der Propellerfreifahrtcharakteristik im zweiten und dritten Quadranten in Polynomform
No full textHaasia stenopodium Strasser 1966
No full textNew data for Haasia stenopodium (Strasser, 1966) CROATIA: 1 ♂, 2 ♀♀, Pepelarica Pit, Middle Velebit, 4 Jul. 2015, leg. G. Rnjak (CBSS); 1 ♂, 3 ♀♀, Meduza Pit, Crikvena, North Velebit National Park, 4 Aug. 2015, leg. B. Jalžić (CBSS). SLOVENIA: 1 ♀, Velika Ledenica u Paradani Pit, Lokve, Batuje, Nova Gorica, 6 Apr. 2014, leg. T. Delić & Š. Borko (IZB); 1 ♂, same data except Jun. 2014, leg. Š. Borko (IZB); 2 ♂♂, 1 juvenile, Brezno Treh Src, Cifre, Snežnik, 12 Sep. 2015, leg. T. Delić (IZB); 1 ♂, 2 ♀♀, 2 juveniles, Brajnice Pit, Dobec, Bezuljak, 14 Nov. 2015, leg. T. Delić (IZB).Published as part of Dragan Ž. Antić, Tvrtko Dražina, Tonći Rađa, Luka R. Lučić & Slobodan E. Makarov, 2016, Taxonomic status of the family Biokoviellidae Mršić, 1992 (Diplopoda, Chordeumatida): reconsideration, with a description of one new species, pp. 1-23 in European Journal of Taxonomy 205 on page 18, DOI: 10.5852/ejt.2016.205, http://zenodo.org/record/26927
Structural basis for m(3)G-cap-mediated nuclear import of spliceosomal UsnRNPs by snurportin1
Get PDFIn higher eukaryotes the biogenesis of spliceosomal UsnRNPs involves a nucleocytoplasmic shuttling cycle. After the m(7) G-cap-dependent export of the snRNAs U1, U2, U4 and U5 to the cytoplasm, each of these snRNAs associates with seven Sm proteins. Subsequently, the m(7)G-cap is hypermethylated to the 2,2,7-trimethylguanosine (m(3)G)-cap. The import adaptor snurportin1 recognises the m(3)G-cap and facilitates the nuclear import of the UsnRNPs by binding to importin-beta. Here we report the crystal structure of the m(3)G-cap-binding domain of snurportin1 with bound m(3)GpppG at 2.4 angstrom resolution, revealing a structural similarity to the mRNA-guanylytransferase. Snurportin1 binds both the hypermethylated cap and the first nucleotide of the RNA in a stacked conformation. This binding mode differs significantly from that of the m(7)G-cap-binding proteins Cap-binding protein 20 (CBP20), eukaryotic initiation factor 4E (eIF4E) and viral protein 39 (VP39). The specificity of the m(3)G-cap recognition by snurportin1 was evaluated by fluorescence spectroscopy, demonstrating the importance of a highly solvent exposed tryptophan for the discrimination of m(7)G-capped RNAs. The critical role of this tryptophan and as well of a tryptophan continuing the RNA base stack was confirmed by nuclear import assays and cap-binding activity tests using several snurportin1 mutants
A conceptual framework for cautious escalation of anticancer treatment: How to optimize overall benefit and obviate the need for de-escalation trials.
No full textBACKGROUND
The developmental workflow of the currently performed phase 1, 2 and 3 cancer trial stages lacks essential information required for the determination of the optimal efficacy threshold of new anticancer regimens. Due to this there is a serious risk of overdosing and/or treating for an unnecessary long time, leading to excess toxicity and a higher financial burden for society. But often post-approval de-escalation trials for dose-optimization and treatment de-intensification are not performed due to failing resources and time. Therefore, the developmental workflow needs to be restructured toward cautious systemic cancer treatment escalation, in order to guarantee optimal efficacy and sustainability.
METHODS
In this manuscript we discuss opportunities to produce the information needed for cautious escalation, based on models of cancer growth and cancer kill kinetics as well as exploratory biomarkers, for the purpose of designing the optimal phase 3 superiority trial. Subsequently, we compare the sample size needed for a phase 3 superiority trial, followed by a necessary de-escalation trial with the sample size needed for a multi-arm phase 3 trial with intervention arms of differing intensity. All essential items are structured within a Framework for Cautious Escalation (FCE). The discussion uses illustrations from the breast cancer setting, but aims to be applicable for all cancers.
RESULTS
The FCE is a promising model of clinical development in oncology to prevent overtreatment and associated issues, especially with regard to the number of repetitive treatment cycles. It will hopefully increase the relevance and success rate of clinical trials, to deliver improved patient-centric outcomes
Über Grenzen verbinden: Rezente Debatten zur Migrationsforschung in der Sozial- und Kulturanthropologie
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