133 research outputs found
Prefazione
No full textSi descrivono storia e linee di sviluppo della prima fortuna dell'opera di Carlo Emilio Gadd
La favola e l’istante. Gadda e il ”passo” del racconto (note introduttive)
No full textThe article offers an initial approach to Carlo Emilio Gadda’s “narrative method”, which is explored starting from the construction of the sentence and then focusing on the writing of the author on a more general level. The analysis takes its start from an acknowledgement of the fragmentary status of Gadda’s narrative form and examines it in light of the opposition between two regimes of the enunciative process: the diegema and the noema
Appunti sulla militanza di Gadda
No full textSi analizzano le occorrenze del lessema "ideologia" nella scrittura - specie saggistica - di Carlo Emilio Gadda; da questo, e da altri indizi testuali, si definisce la sua idea circa il rapporto tra letteratura e società
Le recensioni di Gadda
No full textSi definiscono i termini con i quali Carlo Emilio Gadda "legge" e recensisce opere letterarie di altri scrittori o - in certi casi - testi di critica letteraria. Ne risulta un fatto apparentemente singolare (ma alla fine del tuto comprensibile): il raffinatissimo "stilista" Gadda non si interessa granché a linguaggio e a stile delle opere che studia
Il Monastero di S. Salvatore di Bordonaro. Storia e Documenti (secoli XII-XVI)
No full textDiplomatic edition with historical introduction of 15 greek and latin documents drawn in Sicily between the XIIth and the XIIIth C. concerning a greek monastery founded in the early Normand period. The edition is completed by a commentary to each act and the regestes of the later archival production now conserved in the Fundación Casa Ducal de Medinaceli in Toledo
Cronache-Edizioni e commenti 12/07
No full textEdizioni di Petrarca in occasione del settimo centenario della sua nascita (S. Morrone); F. Guicciardini, Più consigli et avvertimenti, Plusieurs advis et conseils (R. Castagnola);G. Leopardi, Lettere (R. Stracuzzi); R. Serra, Le Lettere (R. Stracuzzi)
Osservazioni sui falsi privilegi di Arcadio e di Ruggero II per Messina e sul Praxeon ton basileon
No full textIl contributo propone nuove ipotesi sulla cronaca apocrifa e inedita intitolata Praxeon ton basileon, sulla sua datazione e sui rapporti con il falso privilegio di Arcadio per la città di Messina, tradizionalmente datato al XV secolo, ma da Federico Martino invece ritenuto del 1282
Identification of a novel SH3PXD2B::FER fusion in a case of plexiform myofibroblastic tumor and review of the literature
No full textFibroblastic/myofibroblastic tumors encompass a wide spectrum of lesions. Among them, plexiform myofibroblastoma (PM) represents a rare and distinctive entity recently described as mostly occurring in children and with a favorable prognosis. Histologically, PM shows SMA, CD34, and desmin expression in most cases, while it is negative for β-catenin and S100. To date, the molecular mechanisms underlying PM tumorigenesis remain largely unknown. Herein, we describe a 7-year-old girl with a myofibroblastic lesion with plexiform features arising in the right deltoid region. The tumor proved positive for SMA staining, in absence of desmin, CD34, S100, and EMA expression. RNAseq analysis revealed a novel in-frame SH3PXD2B::FER fusion gene. The FER gene encodes a cytoplasmic tyrosine kinase which is implicated in several biologically aggressive tumors, where it is overexpressed and associated with EGFR recycling and stabilization. In our case, immunohistochemical analysis revealed a strong positivity for EGFR indicating an upregulation of EGFR transcription that might correlate with the novel chimeric protein involving the FER kinase domain. To our knowledge, the SH3PXD2B::FER fusion has never been reported previously. Whether the current case represents an example of a plexiform myofibroblastic tumor or a distinct tumor entity remains to be determined
The control of epidermal stem cells (holoclones) in the treatment of massive full-thickness burns with autologous keratinocytes cultured on fibrin. [5YIF: 3.60, Citations: 215]
No full textBACKGROUND: Cell therapy is an emerging therapeutic strategy aimed at replacing or repairing severely damaged tissues with cultured cells. Epidermal regeneration obtained with autologous cultured keratinocytes (cultured autografts) can be life-saving for patients suffering from massive full-thickness burns. However, the widespread use of cultured autografts has been hampered by poor clinical results that have been consistently reported by different burn units, even when cells were applied on properly prepared wound beds. This might arise from the depletion of epidermal stem cells (holoclones) in culture. Depletion of holoclones can occur because of (i) incorrect culture conditions, (ii) environmental damage of the exposed basal layer of cultured grafts, or (iii) use of new substrates or culture technologies not pretested for holoclone preservation. The aim of this study was to show that, if new keratinocyte culture technologies and/or "delivery systems" are proposed, a careful evaluation of epidermal stem cell preservation is essential for the clinical performance of this life-saving technology.
METHODS:
Fibrin was chosen as a potential substrate for keratinocyte cultivation. Stem cells were monitored by clonal analysis using the culture system originally described by Rheinwald and Green as a reference. Massive full-thickness burns were treated with the composite allodermis/cultured autograft technique.
RESULTS:
We show that: (i) the relative percentage of holoclones, meroclones, and paraclones is maintained when keratinocytes are cultivated on fibrin, proving that fibrin does not induce clonal conversion and consequent loss of epidermal stem cells; (ii) the clonogenic ability, growth rate, and long-term proliferative potential are not affected by the new culture system; (iii) when fibrin-cultured autografts bearing stem cells are applied on massive full-thickness burns, the "take" of keratinocytes is high, reproducible, and permanent; and (iv) fibrin allows a significant reduction of the cost of cultured autografts and eliminates problems related to their handling and transportation.
CONCLUSION:
Our data demonstrate that: (i) cultured autografts bearing stem cells can indeed rapidly and permanently cover a large body surface; and (ii) fibrin is a suitable substrate for keratinocyte cultivation and transplantation. These data lend strength to the concept that the success of cell therapy at a clinical level requires cultivation and transplantation of stem cells. We therefore suggest that the proposal of a culture system aimed at the replacement of any severely damaged self-renewing tissue should be preceded by a careful evaluation of its stem cell population
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