215 research outputs found
89. OLMO E., MORESCALCHI A., PISANO E., STANYON R., 1991. A deeper insight into sex chromosomes, Nor and heterochromatin in two antarctic ice-fishes.
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Coping with aggressive behaviour from people with dementia
No full text Experiencing aggression in people with dementia can have a terrible impact on care staff. In this article, Miriam Ruth Stanyon describes a three-pronged approach to preventing, managing and coping with aggression in people with dementia </jats:p
Molecular and classical cytogenetic analyses demonstrate an apomorphic reciprocal chromosomal translocation in Gorilla gorilla
No full textThe existence of an apomorphic reciprocal chromosomal translocation in the gorilla lineage has been asserted or denied by various cytogeneticists. We employed a new molecular cytogenetic strategy (chromosomal in situ suppression hybridization) combined with high-resolution banding, replication sequence analysis, and fluorochrome staining to demonstrate that a reciprocal translocation between ancestral chromosomes homologous to human chromosome 5 and 17 has indeed occurred
Counterfeits, Contraltos and Harmony in De Quincey’s Sublime
No full textWhat counts as legitimately sublime and what as counterfeit? The question of policing boundaries is internal to the sublime, and particularly fraught insofar as it is defined as transgressing limits of various kinds. If music is included in the sublime – by no means a foregone conclusion in its history – then what sort of music? Must it be violent, shocking or dissonant, transgressing orderly harmony in some obvious way? This chapter examines the fraught status and remit of harmony in the literary-critical discourse of the sublime. When music and musical concepts appear within broader scholarship on the sublime, they are often aligned with dissonance and irresolvability, as part of a construction of modernity likewise aligned with the breaking of old orders and harmonies. The chapter complicates this view through a double study of the late Romantic author Thomas De Quincey and his favourite singer, the Italian contralto Josephine Grassini. It examines both the multifaceted work to which music and harmony are put in De Quincey’s Confessions (1821), and the complexity of Grassini’s performances beyond the limits of the text, including her vocal traits, gendering, roles and repertoire during the Napoleonic wars, leading to reconsideration of sublimity’s relationship to pathos alongside harmony
Play to learn. Teach by play
No full textThe synthesis provided by Kline in the target article is noteworthy, but ignores the inseparable role of play in the evolution of learning and teaching in both humans and other animals. Play is distinguished and advantaged by its positive feedback reinforcement through pleasure. Play, especially between adults and infants, is probably the platform from which human learning and teaching evolved
Fluorescence in situ hybridization probe preparation
No full textThe public human genome sequencing project utilized a hierarchical approach. A large number of BAC/PAC clones, with an insert size approximate from 50 kb to 300 kb, were identified and finely mapped with respect to the Sequence Tagged Site (STS) physical map and with respect to each other. A “golden path” of BACs, covering the entire human genome, was then selected and each clone was fully sequenced. The large number of remaining BACs was not fully sequenced, but the availability of the end sequence (~800-1000 bp) at each end allowed them to be very precisely mapped on the human genome. The search for copy number variations of the human genome used several strategies. One of these approaches took advantage of the fact that fosmid clones, contrary to BAC/PAC clones, have a fixed insert size (~40 kb) (Kidd et al., Nature 453: 56-64, 2008). In this context, the ends of ~7 million fosmid clones were sequenced, and therefore it was possible to precisely map these clones on the human genome. In summary, a large number of genomic clones (GC) are available for FISH experiments. They usually yield bright FISH signals and are extremely precious for molecular cytogenetics, and in particular cancer cytogenetics. The already-labeled probes available commercially are usually based on a combination of such GCs. The present chapter summarizes the protocols for extracting, labeling, and hybridization onto slides of DNA obtained from GC
Filogeneomica comparata tra Primati e Scandentia: il mappaggio delle sonde cromosomiche umane su Tupaia minor (Scandentia)
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