41 research outputs found
Kaynar, L., Cetin, A., Hacıoğlu, SK., Eser, B., Koçyiğit, I., Canöz, Ö., Tasdemir, A., Karadağ, C., Kurnaz, F., Saraymen, R., Silici, S. Efficacy of royal jelly on methotrexate-induced systemic oxidative stres and damage to small intestine in rats
No full textEffects of age and anxiety on learning and memory
No full textThis study aims to investigate the effects of age and anxiety on behavior, learning and memory in rats. Before and after the anxiety and learning tests, locomotor activity, exploratory activity and autonomic functions of the rats were tested in open field area. At the beginning and at the end of behavior tests, urines were collected so as to determine 5-hydroxyrindolaceticacid (5-HIAA) levels. Following these tests, rats were anesthetized and their serum corticosteron (CORT) levels were analyzed. Behav Brain Res. 2008 Dec 16;195(1):147-52. doi: 10.1016/j.bbr.2008.05.023. Epub 2008 Jun 8. Effects of age and anxiety on learning and memory. Küçük A, Gölgeli A, Saraymen R, Koç N. Author information Dumlupinar University, Medicine Faculty, Physiology Department, Tavsanli Road 10.km, 43270 Kutahya, Turkey. [email protected] Abstract This study aims to investigate the effects of age and anxiety on behavior, learning and memory in rats. Before and after the anxiety and learning tests, locomotor activity, exploratory activity and autonomic functions of the rats were tested in open field area. At the beginning and at the end of behavior tests, urines were collected so as to determine 5-hydroxyindolaceticacid (5-HIAA) levels. Following these tests, rats were anesthetized and their serum corticosteron (CORT) levels were analyzed. After anxiety, except for defecation, all parameters in open field such as line crossing, rearing, sitting and number of grooming were decreased in both young and aged animals. 5-Hydroxyindolaceticacid levels were decreased and serum CORT levels were increased, it is supported that especially the aged rats were much more affected from anxiety compared to the young ones. Elevated T-maze results show that emotional learning did not change while conditioned performance was tested in the closed arm and unconditioned performance was tested in the open arm. Nevertheless, it is observed that aging leaded to extensions in avoidance responses and thus caused difficulty in learning. In water maze test, rats showed higher performance in reaching the platform in repetitive trials; this demonstrates that they have learned by environmental cues. Experimental group had not better performance in reaching the platform according to control group, so this supports that anxiety affects spatial learning. As a conclusion, it could be stated that especially in aged rats, anxiety that is created by elevated T-maze and cat odor and supported with 5-hydroxyindoleacetic acid and serum corticosterone, causes difficulty in emotional and spatial learning. </p
Novel Biomarker for Measuring NADPH Oxidase Activity: A Preliminary Study
No full textErciyes University Scientific Research Projects BAP Unit [TSA-2024-13659]This study was supported by grants from Erciyes University Scientific Research Projects BAP Unit as TSA-2024-13659 project. Ethical approval number: 2023/482
Paşaoğlu H, Tayyar M, Başbuğ M, Saraymen R, Üstdal M: Kayseri yöresi gebelerinde serum biyokimyasal değişimleri.
No full textSmoking-Induced Bone Defects May Be Due to Oxidative Damage in Postmenopausal Women
No full textObjective: Smoking has been implicated as a risk factor for bone defects in postmenopausal women (PMW). The exact mechanism by which it exerts its negative effects on bone is not yet fully known. The purpose of this study was to investigate the impact of smoking on the oxidative status in PMW) and to assess the relationship between one mineral density (BMD) and these oxidant/antioxidant parameters. Material and Methods: The female subjects were randomly selected with simple sampling method according to smoking habits among those presenting to outpatient menopause clinics for menauposal symptoms [smokers (n= 30), mean age was 49.7 +/- 3.5 and non-snonsmokers (n= 30), mean age 51.2 +/- 3.4]. Antioxidant enzymes including superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and paraoxonase (PON), oxidative stress biomarkers such as malondialdehyde (MDA) and nitric oxide (NO) levels, hormonal status, bone turnover markers and BMD were evaluated. Results: Femoral bone and lumbar spine dual-energy X-ray absorptiometry (DEXA) results revealed that the rate of osteopenia and osteporosis in smokers and non-smokers were 75% and 52.5%, respectively. The T-scores were lower in smokers than non-smokers (median -2.7 [percentile, (-3.8%)-(-23%)] and median -1.4 [percentile, (-1.9%)+0.9%)]; p< 0.001). The activities of antioxidant enzymes SOD, GSH-Px and PON were lower and the levels of oxidative stress products MDA and NO were higher in smokers than in non-smokers (p< 0.001). We found a significant correlation between decreased T-score and oxidative stress parameters in the smoking group. A positive correlation was found between the T-score and SOD (r= 0.39, p= 0.035), GSH-Px (r= 0.37, p= 0.046) and PON (r= 0.48, p= 0.008). There was a negative correlation between the T-score and the NO level (r= -0.39, p= 0.032), but no significant correlation was found between MDA levels and the T-score (r= -0.15, p= 0.430). Conclusion: This increased oxidative stress may represent a risk factor for the progress of osteoporosis in smoking PMW. Further studies are needed to clarify the role of smoking on oxidative bone damage and the underlying mechanisms must be addressed
The role of lipoxin A4 in exercise-induced bronchoconstriction in asthma
No full textBackground. The pathogenesis of exercise-induced bronchoconstriction in asthma is incompletely understood, and the role of lipoxin A4 has not been investigated. Objective. To investigate the involvement of lipoxin A4 in exercise-induced bronchoconstriction. Methods. Two groups of children were enrolled in the study: asthmatic children with positive (n = 12) and negative (n = 8) responses to exercise. Levels of lipoxin A4 were determined in plasma before and immediately after exercise challenge using enzyme-linked immunosorbent assay. Results. No significant difference was observed in the pre-exercise lipoxin A4 levels among the groups (p 0.05). A significant difference was observed in the postexercise lipoxin A4 levels between the two groups (p = 0.041). We also observed significant decreases in plasma lipoxin A4 levels immediately after exercise challenge both in asthmatic children with positive responses to exercise (p = 0.013) and negative responses to exercise (p = 0.05). But these levels were significantly higher in asthmatic children with negative responses to exercise (p = 0.041). There was an inverse correlation between lipoxin A4 levels and a reduction in forced expiratory volume at one second percent after exercise (p = 0.045, r = -0.465). Conclusion. Our results are the first demonstration of the lower levels of lipoxin A4 associated with exercise-induced bronchoconstriction in asthma. We hypothesize that the development of exercise-induced bronchoconstriction in asthmatic children may be in relation to a reduced endogenous lipoxin biosynthetic capability. Lipoxin mimetics and related compounds could provide novel therapeutic approaches to the treatment of exercise-induced bronchoconstriction in asthma
Brown Swiss Irkı Sütlerde Ca ve P İçeriğinin Diğer Bileşenlerle (Protein,Toplam Kuru Madde, Kül) İlişkisi
No full textSerum cadmium levels of people living in Kayseri-Belsin Region-Turkiye
No full textConcentrations of cadmium in blood serum of samples of 84 (30 male + 54 female) healthy people living in Belsin-Kayseri, near the great industrial zone of Kayseri named Organize Sanayi Bolgesi, were determined by Graphite Furnace Atomic Absorption Spectrometry. The mean concentration of Cd was found to be 5.98 ± 0.66 µg/l. The serum cadmium concentration of persons living in this region are approximately three times higher than the world values
Element content of propolis from different regions of Turkey
No full textLevels of Na, K, Ca, Mg, N, Cu and Zn of propolis samples originating from different geographic locations of Turkey were investigated. Sodium was the most abundant element in the samples. The calcium content was found between 0.118-0.0793 mg g-1. The highest magnesium content was found in samples from Yozgat region, whereas the lowest was in those of Adana region. Potassium content changed between 0.121-0.364 mg g-1. There were no statistical differences in nitrogen levels. Interestingly, no sulphur (S) was detected in propolis samples. The copper and zinc content changed between 0.045-0.096 mg g-1, 0.176-0.676 mg g-1, respectively. Finally, mineral content of Turkish propolis was about the same as the commercial propolises from other countries. The content of Cu in propolises was generally within safe limits, and compared well with levels in foods from Turkish Food Codex, though Zn contents were high
