42 research outputs found
Kollimalai Masi Periyannasamy – Prayers and Offerings
No full textMasi Periyannasamy is known as the village guardian deity located in Kollimalai Masi hills in Namakkal district. The structure of temple is built under a roof covered with grass. It has a lion as its vehicle. This temple at Masi hills is considered to be the original temple. It is said that Masi Periyannan Swamy temples have been constructed at Namakkal and Trichy by taking soil from this temple. The little deity is associated with folklore and dialects. This idolatry began to worship human beings in order to continuously exchange the memory of the ancestors who lived with them among the progeny and to worship them in the hope that they might help them in some way or the other. While prayer and offering obeisance are fundamental to these two forms of worship, it is different in terms of Saivism and Non-vegetarianism. In the form of minor deity worship, worship is mostly non-vegetarian. There is no sacrifice in the worship of the great deity. But it assumes significance in the worship of the minor deities. However, there is also a tendency for people who are overly believers in the worship of the deity to associate the minor deity with the deities like Shiva and Thirumal. But it does not have long-standing legends. Associated with folk tales, they see Shiva as the form and the incarnation of Thirumal. In this system, nowadays there is a tendency for people to see Kollimalai Masi Periyannasamy, a small deity, as an incarnation of Thirumal. In this article, the methods of worship performed to Masi Periyannasamy are dealt with
Chronomodulated drug delivery systems for the treatment of hypertension: An overview
No full textThis review paper aims to provide an overview of chronomodulated drug delivery systems for the treatment of hypertension. Hypertension is a chronic medical condition that affects millions of people worldwide, and effective treatment is crucial to prevent complications such as heart disease and stroke. Chronomodulated drug delivery utilises the concept of circadian rhythms to optimise drug efficacy and minimise side effects. The paper examines various chronomodulated drug delivery approaches, including pulsatile, delayed-release, and chronopharmaceutical systems, highlighting their advantages and limitations. Furthermore, the potential future developments in this field are discussed, emphasising the importance of personalised medicine and the integration of wearable technology for real-time monitoring and drug administration. Overall, this review provides valuable insights into the potential of chronomodulated drug delivery systems for improving patient outcomes and minimising side effects. By utilising chronomodulated drug delivery approaches, healthcare professionals can ensure that medications are released at specific times when they are most effective, thereby maximising their therapeutic benefits. Pulsatile drug delivery systems, for example, can mimic the body's natural circadian rhythm, allowing for targeted drug release during periods of peak efficacy. Delayed-release systems, on the other hand, can help reduce side effects by delivering drugs to specific regions of the gastrointestinal tract where they are better tolerated
MONSTER PHASE OF ACETAMINOPHEN USE IN PREGNANCY: CURRENT VISION OF AN OLD DRUG
No full textIn various countries, Acetaminophen [APAP] is the frequently used painkiller found in hundreds of medications during pregnancy. It has been broadly used for eras and health care professionals prefer acetaminophen as a choice during pregnancy for relieving pain and fever. Current research reports bothersome inclinations in the rate of acetaminophen exposure and related pregnancy outcome. The exposure of pregnant women to acetaminophen is of great concern. Existing literature evidence shows that acetaminophen exposure during pregnancy may leads to preterm birth, attention deficit hyperactivity disorder (ADHD), autism, male infertility, asthma in pediatrics. Therefore, the prophylactic anticipation of acetaminophen exposure can be a far-sighted approach in order to safeguard humans and wildlife from enduring dangerous effects. This article reviews the epidemiological findings and aims to shed awareness into the second generation outcome of an old drug in pregnant women.</jats:p
Tapentadol: Use and Abuse: Tapentadol – Use and Abuse
No full textTapentadol is a synthetic opioid analgesic that has been on the market in India since 2011. According to international studies, there is a low danger of abuse and diversion. Prescription opioid pain reliever abuse remains a major public health concern. Tapentadol, a prescription painkiller, differs from opioids such as oxycodone and morphine in that it has two modes of action: opioid receptor agonism and norepinephrine reuptake inhibition. Tapentadol has been on the market in India for eight and a half years. Our center was the topic of a single peer-reviewed research in 2017 that detailed two instances of abuse. Tapentadol is less likely to be diverted, abused, addicted, overdosed, or sold on the street than other prescribed opioids. This article reviews uses, pharmacological properties and abuse of tapentadol as it is the most serious issues like addiction, seeking behavior, withdrawal, and physical dependency .The main challenge with tapentadol use is controlling the ratio of MOR agonist to NRI. Finally, tapentadol provides both nociceptive and neuropathic pain relief, but there are concerns about abuse and reliance.
Keywords: Tapentadol, Abuse, Opioid, Addiction
AN ASSESSMENT OF POTENTIAL DRUG-DRUG INTERACTIONS IN HYPERTENSIVE PATIENTS IN A TERTIARY CARE HOSPITAL
No full textObjective: To an assessment of potential drug-drug interactions in hypertensive patients in a tertiary care hospital.
Methods: A prospective, observational study was conducted at a tertiary care hospital, Erode for a period of 8 mo. A sample of 480 patients was assessed for PDDIs using drug checker in Micromedex®-2.7.
Results: A total of 430 patients were analyzed and it was found to be 396 (82.50%) hypertensive patients had PDDIs, and a sum total of 1160 PDDIs were observed. Potential drug-drug interactions (PDDIs) higher in female hypertensive patients [255 (64.39%)] compared to males. Incidences of PDDIs were found to be higher in the age group of 60-70 y were [177 (44.69%)] and incidences of interactions based on the duration of (4-6 d) hospital stays were 272 (68.68%). Moreover, 49.24% of patients were found to be prescribed with more than 7 drugs, with higher incidences of PDDIs. Some of the most common drug interacting pair was between aspirin and clopidogrel combination observed in 325 PDDIs in the major, with pharmacodynamics in nature.
Conclusion: Clinical pharmacist ought to have the role of regular monitoring of drug therapy in identifying and preventing the medications that have the potential to cause drug-drug interactions, thereby minimizing the undesirable outcomes in drug medical care and improving the quality of care
A CRITIQUE ON CANCER VACCINE.
No full textThe goal of a successful vaccine is to prepare the immune system for invasion of a foreign pathogen and teach them to recognize antigens as well as reduce the risk of transmission. In the field of cancer, vaccines are found to be the latest discovery. Provenge? (Sipuleucel-T) is the only vaccine approved by Food and Drug Administration for the treatment of cancer. Vaccines are an appealing therapeutic strategy because they are specific. In addition they stimulate the adaptive immune system, thereby producing a memory response allowing for sustained effect without repeated therapy. Revelation of a potential anticancer treatment is as yet a test to the researchers. Thus, the development of effective cancer vaccines require, thoughtful clinical trials, and scientific progress which might induce long-term specific anticancer response and could contribute to effective and lasting elimination of malignant cells.</p
Role of chloroquine as an anticancer agent
No full textChloroquine is a prototype antimalarial drug used to prevent and treat malaria, amebiasis and other autoimmune disorders such as rheumatoid arthritis and systemic lupus erythematosus. The drug acts as an autophagy inhibitor were autophagy is a self-destructive process which is needed to balance sources of energy at developmental process and in response to nutrient deprivation. New studies have shown the crucial role of chloroquine in cancer treatment and is been extensively used as a monotherapy or adjunct therapy in various types of cancer. This review summarizes the role of chloroquine and its action as an autophagy inhibitor in cancer treatment and also the various safety issues concerning with the same.
Keywords: Adjuanct therap; Autophagy inhibitor; Chloroquine; Monotherapy</jats:p
EXPERIMENTAL DESIGN APPROACH TO FABRICATE AND OPTIMIZE FLOATING TABLETS OF LEVOFLOXACIN FOR HELICOBACTER PYLORI INFECTION
No full textObjective: To improve the treatment of H. pylori infection, by achieving the required bactericidal concentrations of antibiotics in the stomach, by delivering the antibiotics to the mucus layer and release the drug at the site of infection for a prolonged period would be significantly more effective than conventional dosage forms.
Methods: The experimental method of the research was designed to prepare Levofloxacin floating by using Hydroxypropyl Methylcellulose (HPMC K4M), Hydroxypropyl Methylcellulose (HPMC K100M) and Xanthan gum by Three-level Box–Behnken design optimization method. The prepared tablets were evaluated for Thickness, Hardness, Friability, Weight variation, Swelling index (SI), Floating lag time (FLT) and Time required to release 90% of the drug from the tablet (T90%).
Results: It was found that the Thickness-3.12±0.11 mm to 3.28±0.10 mm, Hardness-4.52±0.36 kg/cm2 to 4.81±0.24 kg/cm2, Friability-0.81±0.02g to 0.86±0.12g, Weight variation-480±1.90 mg to 523±0.89 mg, Swelling index (SI)-61.9±0.624% to 99.95±0.226%, Floating lag time (FLT)-81.12±0.63 s to 119.7±0.567 s and Time required to release 90% of the drug from the tablet (T90%)-7.0±0.55 h to 10.33±0.289 h. HPMC K100M and Xanthan gum showed good swelling as compared to HPMC K4M. The study revealed that HPMC K100M grade had a significant effect on drug release.
Conclusion: The developed gastro-floating tablets can extend levofloxacin duration in the stomach and produce a prolonged release effect. The prepared levofloxacin floating tablet oral drug delivery system appears to be a promising choice for the efficient eradication of H. pylor
MONSTER PHASE OF ACETAMINOPHEN USE IN PREGNANCY: CURRENT VISION OF AN OLD DRUG
No full textIn various countries, Acetaminophen [APAP] is the frequently used painkiller found in hundreds of medications during pregnancy. It has been broadly used for eras and health care professionals prefer acetaminophen as a choice during pregnancy for relieving pain and fever. Current research reports bothersome inclinations in the rate of acetaminophen exposure and related pregnancy outcome. The exposure of pregnant women to acetaminophen is of great concern. Existing literature evidence shows that acetaminophen exposure during pregnancy may leads to preterm birth, attention deficit hyperactivity disorder (ADHD), autism, male infertility, asthma in pediatrics. Therefore, the prophylactic anticipation of acetaminophen exposure can be a far-sighted approach in order to safeguard humans and wildlife from enduring dangerous effects. This article reviews the epidemiological findings and aims to shed awareness into the second generation outcome of an old drug in pregnant women
Electronic structure investigations of 1-amino-2,6-dimethylpiperidine by NMR spectral studies by <em>ab initio</em> and DFT calculations
No full text638-648In this work, a combined experimental and theoretical study on molecular structure, vibrational spectra of 1-amino-2,6-dimethylpiperidine (ADP) has been reported. The FTIR and FT-Raman spectrum have been recorded in the region 4000-400 cm-1 and 3500-50 cm-1, respectively. The molecular geometry, harmonic vibrational frequencies and bonding features of ADP have been calculated by using ab initio/HF and density functional theory/B3LYP methods with 6-31+G(d,p) basis set. A detailed interpretation of the FTIR, FT-Raman, NMR spectra of ADP has also been reported. Natural bond orbital analysis has been carried out to explain the charge transfer or delocalization of charge due to the intra-molecular interactions. Energy of the highest occupied molecular (HOMO) orbital and lowest unoccupied (LUMO) molecular orbital have been predicted
