1,720,973 research outputs found
Proteomic approach for the analysis of acrylamide-hemoglobin adducts Perspectives for biological monitoring
No full textThe formation of adducts between acrylamide and hemoglobin in vitro was investigated by using mass spectrometric methodologies to identify the amino acid residues sensitive to alkylation. Liquid chromatography-electrospray ionisation mass spectrometry analysis of either intact or trypsin-digested alpha- and beta-globin chains isolated from hemolysate samples incubated in vitro with acrylamide at different molecular ratios allowed us to identify Cys93 of beta-globin as the most reactive site in hemoglobin, according to a Michael-type addition reaction between acrylamide and the sulphydryl group of cysteine. The only other reactive sites were Cys 104 of alpha-globin and the N-terminal amino groups of both chains. The method developed, based on electrospray ionisation quadrupole time-of-flight tandem mass spectrometry analysis of intact globin chains was able to specifically detect low levels of adducts. In this way, rapid identification of alkylated portion of Hb was achieved to be potentially used as a biomarker for high-sensitivity biological monitorin
Studio sui sintomi soggettivi in addetti alla Risonanza Magnetica Nucleare (RMN)
No full textAlcuni studi nel personale addetto alla Risonanza Magnetica Nucleare (RMM) suggeriscono un’aumentata prevalenza di alcuni sintomi soggettivi quali sensazione di sapore metallico, vertigini e sensazione di movimento, nausea e cefalea, ed un possibile effetto su alcuni test neuro-comportamentali e neurofisiologici, reversibili dopo interruzione dell’esposizione.
I dati sono però moto limitati. In questo lavoro presentiamo uno studio che stiamo avviando su tali sintomi in addetti alla RMN, ed alcuni dati preliminari raccolti in un gruppo pilota per testare lo strumento
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Il contributo al processo formativo in radioprotezione medica dei dati preliminari di un'indagine conoscitiva tra i soci dell'AIRM
No full textarticolo sui risultati ottenuti da un'indagine condotta presso i soci dell'AIRM in merito ai fabbisogni formativi e all'aggiornamento delle competenze in radioprotezione medic
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Prevenzione delle esposizioni accidentali nell’uso di nuove tecnologie per la radioterapia con fascio esterno
No full textTraduzione del volume :ICRP Publication 112 - Preventing Accidental Exposures from New External Beam Radiation Therapy Technologies - Annals of the ICRP Volume 39 Issue 4, 200
Il contributo al processo formativo in radioprotezione medica dei dati preliminari di un'indagine conoscitiva tra i soci dell'AIRM
No full textarticolo sui risultati ottenuti da un'indagine condotta presso i soci dell'AIRM in merito ai fabbisogni formativi e all'aggiornamento delle competenze in radioprotezione medic
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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