1,115 research outputs found
Massively expedited genome-wide heritability analysis (MEGHA)
No full textThe discovery and prioritization of heritable phenotypes is a computational challenge in a variety of settings, including neuroimaging genetics and analyses of the vast phenotypic repositories in electronic health record systems and population-based biobanks. Classical estimates of heritability require twin or pedigree data, which can be costly and difficult to acquire. Genome-wide Complex Trait Analysis (GCTA) is an alternative tool to compute heritability estimates from unrelated individuals, using genome-wide data that is increasingly ubiquitous, but is computationally demanding and becomes difficult to apply in evaluating very large numbers of phenotypes. Here we present a novel, fast and accurate statistical method for high-dimensional heritability analysis using genome-wide single nucleotide polymorphism (SNP) data from unrelated individuals, termed Massively Expedited Genome-wide Heritability Analysis (MEGHA), and accompanying nonparametric sampling techniques that enable flexible inferences for arbitrary statistics of interest. MEGHA produces estimates and significance measures of heritability with several orders of magnitude less computational time than existing methods, making heritability-based prioritization of millions of phenotypes based on data from unrelated individuals tractable for the first time. As a demonstration of application, we conducted heritability analyses on global and local morphometric measurements derived from brain structural magnetic resonance imaging (MRI) scans, using genome-wide SNP data from 1,320 unrelated young healthy adults of non-Hispanic European ancestry. We also computed surface maps of heritability for cortical thickness measures and empirically localized cortical regions where thickness measures were significantly heritable. Our analyses demonstrate the unique capability of MEGHA for large-scale heritability-based screening and high-dimensional heritability profile construction
Megha-Tropiques mission status
No full textThe French-Indian Megha-Tropiques mission was launched in October 2011 from the Satish Dhawan Space Centre in Sriharikota. Onboard the satellite, MADRAS is a conical scanning passive microwave radiometer with 9 channels from 18.6 GHz to 157 GHz dedicated mainly to the retrieval of rain over both land and ocean. The originality of the Megha-Tropiques mission is not so much in the capabilities of the MADRAS instrument which are similar to a SSM/I, but it is in its peculiar low inclination orbit (20°) combined with a large swath (~1700 km) which gives an incomparable revisit over the 23° S-23° N region. The first data received from MADRAS show that the instrument, regardless of some data transmission difficulties, is giving very good quality brightness temperatures with very low noise level even at 89 and 157 GHz. The presentation will give a brief review of the mission status and of the connected scientific activities regarding the rain retrieval algorithms, for both instantaneous products (Level 2) and the 1 degree-1 day product (Level 4). The presentation will also give a brief overview of the algorithm validation activities (microphysics) and products validation (rain) which will be detailed in separate presentations and posters
MT__Paper Supplementary Figures .pptx
No full textBMPR2
dysfunction impairs insulin signaling and glucose homeostasis in cardiomyocytes
Anna
Hemnes MD1, Joshua Fessel MD PhD1,2, 3, Xinping Chen PhD1,
Shijun Zhu PhD1, Niki Fortune BS1, Christopher Jetter BS1,
Michael Freeman PhD4, John Newman MD1, James West PhD1,
Megha Talati PhD1
1 Division of Allergy, Pulmonary
and Critical Care Medicine, Vanderbilt University School of Medicine,
Nashville, TN 37232, USA
2 Department of Pharmacology,
Vanderbilt University Medical Center,
Nashville, Tennessee, USA.
3 National Heart, Lung, and Blood
Institute, National Institutes of Health, Bethesda, Maryland.
4 Department of Radiation Oncology, Vanderbilt University
Medical Center, Nashville, Tennessee.
Corresponding
author:
Megha Talati Email Address: [email protected]</p
Megha-Tropiques mission status
No full textThe French-Indian Megha-Tropiques mission was launched in October 2011 from the Satish Dhawan Space Centre in Sriharikota. Onboard the satellite, MADRAS is a conical scanning passive microwave radiometer with 9 channels from 18.6 GHz to 157 GHz dedicated mainly to the retrieval of rain over both land and ocean. The originality of the Megha-Tropiques mission is not so much in the capabilities of the MADRAS instrument which are similar to a SSM/I, but it is in its peculiar low inclination orbit (20°) combined with a large swath (~1700 km) which gives an incomparable revisit over the 23° S-23° N region. The first data received from MADRAS show that the instrument, regardless of some data transmission difficulties, is giving very good quality brightness temperatures with very low noise level even at 89 and 157 GHz. The presentation will give a brief review of the mission status and of the connected scientific activities regarding the rain retrieval algorithms, for both instantaneous products (Level 2) and the 1 degree-1 day product (Level 4). The presentation will also give a brief overview of the algorithm validation activities (microphysics) and products validation (rain) which will be detailed in separate presentations and posters
Upper Tropospheric humidity from Megha-Tropiques : A humidity-convection study
No full textUpper tropospheric humidity (UTH) and rainfall estimates are produced operationally from Megha-Tropiques observations since its launch on October 12th, 2012. With its low inclination (20°) orbit, this indo-french satellite offers a frequent revisit of the tropical belt giving 3 to 5 passes every day. This configuration provides an interesting sampling of the convective systems during their life that allows studies of their evolution, from their precipitation core to their close environment. The UTH is computed for the 3 upper channels of SAPHIR (±0.2 GHz, ±1.1 GHZ and ± 2.8 GHz) following a well established method applied to water vapor channels (6.3μm: e.g. Soden and Bretherton, 1993; 183 GHz: e.g. Spencer and Braswell, 1997) which gives an idea of the vertical distribution of the relative humidity in the upper part of the troposphere. The CINDY/DYNAMO international campaign that took place over the equatorial Indian Ocean from the 1st October 2011 to the 31 March 2012 aimed to study the conditions for the development of active convection in the context of the MJO (Madden-Julian Osillation). Thanks to a large deployment of ground instruments (SPol-Ka polarimetric radar, Smart-R radar, radiosoundings) and airborne measurements (SAPHIR-Falcon 20, NOAA-P3) it is possible to describe quite thoroughly the whole state of the atmosphere while the Megha-Tropiques satellite (mainly SAPHIR and MADRAS instruments) overpasses. This offers an ideal opportunity to study the relationship between convection and its moist environment. A few case studies are selected from the CINDY/DYNAMO observations and explored with the Megha-Tropiques estimations of rainfall and UTH: a simple eulerian approach is used over the area of activity of the cloudy systems and the distribution of UTH is analyzed and associated to the rainfall rate which is a good signature of the intensity of convectio
Milkweed Assassin Bug (Suggested Common Name) Zelus longipes Linnaeus (Insecta: Hemiptera: Reduviidae)
No full textCommonly called the milkweed assassin bug, because it closely resembles the milkweed bug, it is also known as the longlegged assassin bug and the Zelus assassin bug. Members of the genus Zelus belong to the subfamily Harpactorinae and are diurnal in nature. They are generalist predators feeding on a wide range of soft-bodied prey in garden and fields, such as mosquitoes, flies, earthworms, cucumber beetles, and caterpillars (fall armyworm, rootworm, etc.) Learn more in this 7-page fact sheet written by Megha Kalsi and Dakshina R. Seal and published by the UF Department of Entomology and Nematology Department, February 2011.
EENY489/IN883: Milkweed Assassin Bug (Suggested Common Name) Zelus longipes Linnaeus (Insecta: Hemiptera: Reduviidae) (ufl.edu
The Megha-Tropiques rainfall products ground validation plan
No full textThe Megha-Tropiques satellite, dedicated to water and energy budget in the Tropical atmosphère was successfully launched in October 2011. This Tropical member of GPM will provide an enhanced sampling of the convective systems in the inter-tropical band and will contribute to better estimations of the precipitation in this zone. Applications of the MT rainfall products are expected in a range of fields, ranging from climate studies to hydrology, or even health (vector based disease monitoring). We will review the Megha-Tropiques Ground Validation Activities in the inter-tropical zone. Both direct evaluation of the rainfall products by comparison with ground reference, and integrated (or hydrological) validation are planned. The ground reference will be provided by weather radar or rain gage networks, from operational or research projects. A validation super site based on a polarimetric radar has been set up in West Africa. We will discuss the various methods that will be applied to evaluate both the level 2 (instant rainfall) and level 4 (gridded, daily rainfall) , and how we are intending to account for uncertainties and sampling errors in our validation reports
Milkweed Assassin Bug (Suggested Common Name) Zelus longipes Linnaeus (Insecta: Hemiptera: Reduviidae)
No full textCommonly called the milkweed assassin bug, because it closely resembles the milkweed bug, it is also known as the longlegged assassin bug and the Zelus assassin bug. Members of the genus Zelus belong to the subfamily Harpactorinae and are diurnal in nature. They are generalist predators feeding on a wide range of soft-bodied prey in garden and fields, such as mosquitoes, flies, earthworms, cucumber beetles, and caterpillars (fall armyworm, rootworm, etc.) Learn more in this 7-page fact sheet written by Megha Kalsi and Dakshina R. Seal and published by the UF Department of Entomology and Nematology Department, February 2011.
EENY489/IN883: Milkweed Assassin Bug (Suggested Common Name) Zelus longipes Linnaeus (Insecta: Hemiptera: Reduviidae) (ufl.edu
Milkweed Assassin Bug (Suggested Common Name) Zelus longipes Linnaeus (Insecta: Hemiptera: Reduviidae)
No full textCommonly called the milkweed assassin bug, because it closely resembles the milkweed bug, it is also known as the longlegged assassin bug and the Zelus assassin bug. Members of the genus Zelus belong to the subfamily Harpactorinae and are diurnal in nature. They are generalist predators feeding on a wide range of soft-bodied prey in garden and fields, such as mosquitoes, flies, earthworms, cucumber beetles, and caterpillars (fall armyworm, rootworm, etc.) Learn more in this 7-page fact sheet written by Megha Kalsi and Dakshina R. Seal and published by the UF Department of Entomology and Nematology Department, February 2011.
EENY489/IN883: Milkweed Assassin Bug (Suggested Common Name) Zelus longipes Linnaeus (Insecta: Hemiptera: Reduviidae) (ufl.edu
The Megha-Tropiques rainfall products ground validation plan
No full textThe Megha-Tropiques satellite, dedicated to water and energy budget in the Tropical atmosphère was successfully launched in October 2011. This Tropical member of GPM will provide an enhanced sampling of the convective systems in the inter-tropical band and will contribute to better estimations of the precipitation in this zone. Applications of the MT rainfall products are expected in a range of fields, ranging from climate studies to hydrology, or even health (vector based disease monitoring). We will review the Megha-Tropiques Ground Validation Activities in the inter-tropical zone. Both direct evaluation of the rainfall products by comparison with ground reference, and integrated (or hydrological) validation are planned. The ground reference will be provided by weather radar or rain gage networks, from operational or research projects. A validation super site based on a polarimetric radar has been set up in West Africa. We will discuss the various methods that will be applied to evaluate both the level 2 (instant rainfall) and level 4 (gridded, daily rainfall) , and how we are intending to account for uncertainties and sampling errors in our validation reports
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