467 research outputs found
Una radio di relazioni. Il caso di Radio Cooperativa di Padova
No full textThe research has as object relations that are established between non-mainstream media, their audience and their network of supporters. The moment with the advent of Web 2.0 interactivity between media and users is radically changing the social action and interesting to identify the processes that create a community around an average.
To do this, the emphasis has been on the experience of a Venetian Local Radio, Radio Cooperativa of Padua, a radio based on pure voluntary, not income derived from advertising and is maintained by voluntary contributions from listeners and supporters. As stated mission, the issuer has the "give voice to the voiceless" and deals mainly with issues related to civil rights, environmental protection and peace. The choice of a radio depends on whether the media has long been the way for greater interaction with the audience than other media by using the phoneLa ricerca ha come oggetto le relazioni che si instaurano tra media non mainstream, il loro pubblico e la loro rete di sostenitori. Nel momento in cui con l’avvento del web 2.0 l’interattività tra media e utenti sta radicalmente mutando l’agire sociale e interessante individuare i processi che creano una comunità attorno a un media.
Per fare questo l'attenzione si è rivolta sull'esperienza di una Radio locale veneta, Radio Cooperativa di Padova, una radio basata sul volontariato puro, che non ricava introiti da inserzioni pubblicitarie e viene mantenuta con i contributi volontari di ascoltatori e sostenitori. Come mission dichiarata, l'emittente ha il “dare voce a chi non ha voce” e si occupa, principalmente, di temi legati ai diritti civili, alla salvaguardia dell'ambiente e alla pace. La scelta di una radio dipende dal fatto che questo media ha da tempo reso possibile una maggiore interazione con gli ascoltatori rispetto ad altri media grazie all'utilizzo del telefon
Pollastro F., Rajan T. S., Giacoppo S., Iori R., De Nicola G. R., Grassi G., Bramanti, P., Mazzon E. Effetto antinfiammatorio e antiossidante di una nuova combinazione di cannabidiolo e moringina in macrofagi LPS-stimolati. Modena, Scuola di Fitochimica “P. Ceccherelli” 10-12 giugno 2016
No full textLe risposte ai questionari
No full textIl capitolo presenta e commenta i risultati di 1483 questionari somministrati a studenti dei licei scientifici (751) e degli istituti professionali (732) in quattro regioni italiane relativamente alla percezione delle differenze culturali. Ove possibile, i dati vengono confrontati con dati Eurobarometro a livello italiano e dell'Unione Europea
Novel Gram-Scale Production of Enantiopure R-Sulforaphane from Tuscan Black Kale Seeds
No full textDietary R-sulforaphane is a highly potent inducer of the Keap1/Nrf2/ARE pathway. Furthermore, sulforaphane is currently being used in clinical trials to assess its effects against different tumour processes. This study reports an efficient preparation of enantiopure R-sulforaphane based on the enzymatic hydrolysis of its natural precursor glucoraphanin. As an alternative to broccoli seeds, we have exploited Tuscan black kale seeds as a suitable source for gram-scale production of glucoraphanin. The defatted seed meal contained 5.1% (w/w) of glucoraphanin that was first isolated through an anion exchange chromatographic process, and then purified by gel filtration. The availability of glucoraphanin (purity ≈ 95%, weight basis) has allowed us to develop a novel simple hydrolytic process involving myrosinase (EC 3.2.1.147) in a biphasic system to directly produce R-sulforaphane. In a typical experiment, 1.09 g of enantiopure R-sulforaphane was obtained from 150 g of defatted Tuscan black kale seed meal
Liquidity induced asset bubbles via flows of ELMMs
No full textWe consider a constructive model for asset price bubbles, where the market price is endogenously determined by the trading activity on the market and the fundamental price is exogenously given, as in [R. Jarrow, P. Protter, and A. Roch, Quant. Finance, 12 (2012), pp. 1339--1349]. To justify from a fundamental point of view, we embed this constructive approach in the martingale theory of bubbles (see [R. Jarrow, P. Protter, and K. Shimbo, Math. Finance, 20 (2010), pp. 145--185] and [F. Biagini, H. Föllmer, and S. Nedelcu, Finance Stoch., 18 (2014), pp. 297--326]) by showing the existence of a flow of equivalent martingale measures for , under which equals the expectation of the discounted future cash flow. As an application, we study bubble formation and evolution in a financial network
Anti‐inflammatory effects of hypoxia‐preconditioned human periodontal ligament cell secretome in an experimental model of multiple sclerosis: a key role of IL‐37
No full textRecent research has widely investigated the anti-inflammatory effects of mesenchymal stem cells and their secretory products, termed the secretome, in the treatment of multiple sclerosis (MS). The present study examined the capacity of the conditioned medium (CM) from human periodontal ligament stem cells (hPLSCs) under hypoxia (H-hPDLSCs-CM) to suppress experimental autoimmune encephalomyelitis (EAE), a murine model of MS. To induce EAE, female C57BL/6 mice were immunized with myelin oligodendroglial glycoprotein peptide35-55 At the onset of symptoms, H-hPDLSCs-CM was infused via the tail vein of mice. Our results demonstrate the efficacy of H-hPDLSCs-CM treatment in diminishing clinical and histologic disease score. A key finding from this study is the marked expression of anti-inflammatory cytokine IL-37, paralleled by the suppression of proinflammatory cytokines in mice with EAE that were treated with H-hPDLSCs-CM. In addition, a consequent modulation of oxidative stress, autophagic, and apoptotic markers was observed in mice with EAE after hPDLSCs-CM administration. In addition, to provide additional evidence of the molecular mechanisms that underlie H-hPDLSCs-CM, we investigated its therapeutic action in scratch injury-exposed NSC-34 neurons, an in vitro model of injury. This model reproduces severe inflammation and oxidative stress conditions as observed after EAE damage. In vitro results corroborate the ability of hPDLSCs-CM to modulate inflammatory, oxidative stress, and apoptotic pathways. Taken together, our findings suggest H-hPDLSCs-CM as a new pharmacologic opportunity for the management of MS.-Giacoppo, S., Thangavelu, S. R., Diomede, F., Bramanti, P., Conti, P., Trubiani, O., Mazzon, E. Anti-inflammatory effects of hypoxia-preconditioned human periodontal ligament cell secretome in an experimental model of multiple sclerosis: a key role of IL-37
Esplosioni demografiche di Barbitistes vicetinus (Galvagni & Fontana, 1993) (Orthoptera, Tettigoniidae) in Veneto.
No full textStudio dell'umidità ascendente, delle caratteristiche fisiche delle murature di Palazzo Badoer e prove di desalinificazione.
No full textA cura dell’Istituto per lo Studio delle Grandi Masse, CNR
Relapsed/Refractory Diffuse Large B-Cell Lymphoma (R/R DLBCL) Patients: A Retrospective Analysis of Eligibility Criteria for CAR-T Cell Therapy
No full textPatients (pts) with diffuse large B-cell lymphoma (DLBCL) refractory to second-line therapy or relapsed after an autologous stem cell transplant (ASCT) have a very poor clinical outcome with a median overall survival (OS) of 5 and 8-10 months, respectively. Autologous anti-CD19 chimeric antigen receptor (CD19 CAR) T cells have been associated with sustained complete remissions and long-term survivals in a large proportion of pts with R/R DLBCL by the two pivotal clinical trials Zuma1 and Juliet. This has led to the rapid approval by FDA and then by EMA of CAR-T cells for the third-line treatment of R/R DLBCL. Despite being a potentially revolutionary treatment for pts with advanced disease, the costs are much greater than any previously approved cancer therapy and this may become a substantial economic challenge for the health care system. The definition of inclusion and exclusion criteria capable of identifying more precisely pts who can successfully undergo CAR-T cell therapy, minimizing the severity of the toxicity, still remains a matter of discussion. Moreover, some eligible pts run the risk of becoming ineligible because of poor disease control. Indeed, one of the major obstacles to the successful use of CAR-T cells is the 4-5 week period so far required for the manufacturing and transfer of CAR-T cells. To address this issue, we have examined data of R/R DLBCL pts managed between 2010 and 2018 at our Center in order to: 1) better identify the characteristics and outcome of a cohort of R/R DLBCL pts potentially eligible, according to the approval criteria, for CAR-T cell therapy; 2) define factors influencing CAR-T cell eligibility; 3) make a realistic estimate of pts eligible for CAR-T cells. In this retrospective real-life cohort of R/R DLBCLs, 82/480 pts (17%) were R/R tosecond-line treatment including ASCT. Considering Juliet's inclusion/exclusion criteria for CAR-T cell therapy, only 50 pts (10.4%) would be eligible for CAR-T cells. Our analysis suggests that elevated LDH plus ECOG ≥2 have to be considered the two most significant features of very rapid disease progression. These variables should be taken in account in order to better select DLBCL pts potentially eligible to CAR-T therapy
4(α-L-RHAMNOSYLOXY)-BENZYL ISOTHIOCYANATE, A BIOACTIVE PHYTOCHEMICAL THAT DEFENDS CEREBRAL TISSUE AND PREVENTS SEVERE DAMAGE INDUCED BY FOCAL ISCHEMIA/REPERFUSION
No full textNatural compounds are a promising source to treat several pathologies. The present study shows the in vivo pharmacological beneficial effect of 4(α-L-rhamnosyloxy)-benzyl isothiocyanate (glucomoringin isothiocyanate; GMG-ITC) obtained from glucomoringin (GMG; 4(α;-L-rhamnosyloxy)- benzyl glucosinolate), purified from Moringa oleifera seeds and hydrolyzed by myrosinase enzyme (β-thioglucoside glucohydrolase; E.C. 3.2.1.147). Cerebral ischemia/reperfusion (CIR) was induced in rats according to a classic model of carotid artery occlusion for a time period of 1 h and the reperfusion time was prolonged for seven days. GMG-ITC (3.5 mg GMG/ml plus 30 μl enzyme/rat; one ml i.p./rat) was administered 15 min after the beginning of ischemia and daily. The results clearly show that GMG-ITC possesses the capability to counteract the CIR-induced damage reducing TNF-alpha release, IκB-alpha cytosolic degradation/NFκBp65 nuclear translocation, as well as several other direct or indirect markers of inflammation (phospho-ERK p42/44, p-selectin) and oxidative stress (inducible Nitric Oxide Synthase (iNOS), MMP-9). GMG-ITC was shown to exert neuroprotective properties in preventing CIR-induced damage and the related cascade of inflammatory and oxidative mediators that exacerbate the progression of this disease in an experimental rat model. Our results clearly show that the tested phytochemical GMG-ITC possesses the capability to counteract CIR-induced damage
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