736 research outputs found
Postcyberpunk features in the Luben Dilov’s novel «Choosing oneself»
No full textCтаття присвячена актуальній проблемі функціонування посткіберпанку у
фантастичному романі відомого сучасного болгарського письменника. У роботі
названі основні риси посткіберпанку та визначено особливості їх реалізації у тексті. Наголошено на авторському осмисленні окремих екзистенціалів (безсмертя,
самовизначення, сумнів, песимізм, абсурд) як однієї з рис посткіберпанку. Визначено специфіку зображення сновидінь в онейросфері постмодерністського роману,
яка обумовлена авторською настановою зображення боротьби протилежних начал у душі героя, аналізом особливостей його свідомості, творенням нової міфології. Вказані можливі напрями для подальшого дослідження твору: проблематика
сексуальності, фройдизму, оніричного дискурсу.Статья посвящена актуальной проблеме функционирования посткиберпанка в фантастическом романе известного современного болгарского писателя. В
работе названы основные черты посткиберпанка и определены особенности их
реализации в тексте. Отмечено авторское осмысление отдельных экзистенциалов (бессмертие, самоопределение, сомнение, пессимизм, абсурд) как одна из черт
посткиберпанка. Определена специфика изображения сновидений в онейросфере
постмодернистского романа. Указаны возможные направления для дальнейшего
исследования произведения: проблематика сексуальности, фрейдизма, сновидений.The article «Postcyberpunk features in the Luben Dilov’s novel «Choosing Oneself»
is dedicated to the problem of the postcyberpunk’s functioning in the science fiction novel
of the well-known Bulgarian modern writer. The main features of postcyberpunk and
their implementation in the text are analyzed. The functioning of postmodern fiction with
typical for the Bulgarian literature of early 2000s genre diffusion — a combination of techniques
and themes of science fiction, cyberpunk, dystopian — is called by the scientists (eg,
L. Person) postcyberpunk.
It is stated that the work of the Bulgarian writer is highly existential, therefore the
categories of immortality, self determining, exhaustion, doubt, despair, pessimism, death,
immortality absurdity are examined. The author focuses on the question of human immortality:
whether a person who has died several times can be treated as a person and,
ultimately, what is a person? The suffering man «without hope» who doesn’t belong to the
future any longer is a classic type of the existential literature. The postmodern principle of
character destruction realises not only at the psychological and social levels, but also at the
level of actual existence. The scientist Daniel Dimih didn’t exist any more, he was replaced
by the biorobot Brain. Trying to stay a human being when the physical transformations
have turned it into something else bring Luben Dilov closer to the advanced researches of
postcyberpunk.
The specificity of dreams’ images in the postmodern novel is analyzed. A dream in the
novel manifasts itself at several levels: as an actual state of unconsciousness, as a dream
reality and as an alternative space. The possible directions for the further investigations
are: sexuality, Freudism, dream discourse.There are the following elements available in the postcyberpunk novel «Choosing
Oneself»: cyberspace, direct connection of the human brain to the computer systems, artificial
intelligence, bioimplant, nanotechnology, quantum physics, genetic engineering,
social character, an attempt to help humanity, biopunk, cosmopunk. Luben Dilov in his
novel gives new sense to such characteristics of postmodern aesthetics as destruction of
character, the collapse of rationalism, the death of author ect. The article enables the
exploring of the three realities functioning — real, dream and literary. The author points
out that the novel gives many ways of reading and understanding
Propuesta de mejora en las áreas de producción y logística para reducir los costos operativos de la Confitería Luben S. R. L. Trujillo, 2021
No full textEl objetivo del presente trabajo de investigación fue Determinar en que medida la implementación de metodología 5’S, Gestión de almacén, Tiempo estándar y Planificación de Requerimiento de Materiales disminuye los altos costos operativos de la confitería LUBEN S.R.L. El diagnóstico de la situación actual en el área de producción y logística para la línea de tortas determinó altos costos operativos, las pérdidas económicas para el año 2019 son S/ 14,280 en el área de producción y de S/ 33,123 en el área de logística. Con las causas identificadas, el estudio desarrolló propuestas de mejora en base al DOP, DAP, estudio de tiempos, sistema MRP, documentos logísticos, codificación de materiales y codificación por ubicación de los materiales, metodología 5’S, método ABC y Distribución de planta. Además, se incluye el diseño de procedimiento de desarrollo, formatos normalizados que permiten controlar los procesos de producción y la gestión de logística correcta de inventarios y almacén.
Posteriormente se realizo un análisis económico financiero con la finalidad de comprobar que el estudio realizado es viable para la organización puesto que se obtuvo un VAN de S/.79.042.62, TIR de 84.71%, B/C de 1.043 y PRI de 2.6 años, el cual se concluye que la propuesta de mejora es factible y rentable para la confitería LUBEN S.R.L.The objective of this research work was to determine to what extent the implementation of the 5's methodology, Warehouse Management, Standard Time and Material Requirement Planning reduces the high operating costs of the LUBEN S.R.L. confectionery. The diagnosis of the current situation in the production and logistics area for the cake line determined high operating costs, the economic losses for 2019 are S / 14,280 in the production area and S / 33,123 in the logistics area. With the causes identified, the study developed proposals for improvement based on the DOP, DAP, time study, MRP system, logistics documents, materials coding and materials location coding, 5's methodology, ABC method and Plant distribution. In addition, it includes the design of the development procedure, standardized formats that allow control of the production processes and the correct logistics management of inventories and warehouse.
Subsequently, a financial economic analysis was carried out in order to verify that the study carried out is viable for the organization since a NPV of S / .79.042.62, IRR of 84.71%, B / C of 1.043 and PRI of 2.6 years was obtained. , which concludes that the improvement proposal is feasible and profitable for the LUBEN S.R.L. confectioner
Television viewing, walking speed, and grip strength in a prospective cohort study
No full textPurpose: Television (TV) watching is the most prevalent sedentary leisure time activity in the United Kingdom. We examined associations between TV viewing time, measured over 10 yr, and two objective measures of physical capability, usual walking speed (UWS) and grip strength.Methods: Community-based participants (n = 8623; 48–92 yr old) enrolled in the European Prospective Investigation of Cancer—Norfolk study attended a third health examination (3HC, 2006–2011) for measurement of maximum grip strength (Smedley dynamometer) and UWS. TV viewing time was estimated using a validated questionnaire (n = 6086) administered during two periods (3HC, 2006–2007; 2HC, 1998–2000). Associations between physical capability and TV viewing time category (<2, 2 < 3, 3 < 4, and ?4 h·d?1) at the 3HC, 2HC, and using an average of the two measures were explored. Sex-stratified analyses were adjusted for age, physical activity, anthropometry, wealth, comorbidity, smoking, and alcohol intake and combined if no sex–TV viewing time interactions were identified.Results: Men and women who watched the least TV at the 2HC or 3HC walked at a faster usual pace than those who watched the most TV. There was no evidence of effect modification by sex (Pinteraction = 0.09), and in combined analyses, participants who watched for <2 h·d?1 on average walked 4.29 cm·s?1 (95% confidence interval, 2.56–6.03) faster than those who watched for ?4 h·d?1, with evidence of a dose–response association (Ptrend < 0.001). However, no strong associations with grip strength were found.Conclusions: TV viewing time predicted UWS in older adults. More research is needed to inform public health policy and prospective associations between other measures of sedentariness, such as total sitting time or objectively measured sedentary time, and physical capability should be explored.<br/
Cross-sectional associations between different measures of obesity and muscle strength in men and women in a British Cohort Study
No full textObjectives: the relationship between obesity and grip strength, a key indicator of sarcopenia, has been inconsistently reported. We aimed to examine associations between grip strength and both body mass index (BMI), a clinical indicator of total adiposity, and waist circumference (WC), an indicator of central adiposityDesign: cross-sectional studySetting and participants: data collected from 8,441 men and women, aged 48–92 years old, who attended the third health examination of the European Prospective Investigation into Cancer-Norfolk study was usedMeasurements: maximum grip strength (Smedley dynamometer), BMI (weight/height2) and WC (measured at the natural waist) were ascertained at a research clinic. The associations between grip strength and adiposity measures were explored using linear regression with adjustment for age, height, social class, physical activity, prevalent disease, smoking status and alcohol intakeResults: men and women were examined separately and those in the upper quartile of BMI were 2.70kg (95%CI 2.07, 3.33) and 1.46kg (95%CI 1.05, 1.86) stronger respectively than those in the bottom quartile (P trends <0.001). Grip strength also increased weakly with increasing WC. However, including both BMI and WC in the same regression model revealed an inverse association between grip strength and WC, whilst the previously observed association with BMI strengthened. For every 10cm increase in WC, grip strength was 3.56kg (95%CI 3.04, 4.08) lower in men and 1.00kg (95%CI 0.74, 1.24) lower in womenConclusions: larger overall body mass, indicated by higher BMI, is associated with stronger grip strength but high WC, a clinical indicator of central obesity, is associated with lower grip strength. Abdominal fat is the most metabolically active adipose tissue and this provides a clue to potential mechanisms underlying relationships between fat and skeletal muscle. Additionally, it reinforces the recommendation to measure WC in clinical practice, especially when BMI is below obese range
Estimation of disease progression parameters from case-control data: application to mammographic patterns and breast cancer natural history
No full textA genome-wide association study of intra-ocular pressure suggests a novel association in the gene FAM125B in the TwinsUK cohort
No full textGlaucoma is a major cause of blindness in the world. To date, common genetic variants associated with glaucoma only explain a small proportion of its heritability. We performed a genome-wide association study of intra-ocular pressure (IOP), an underlying endophenotype for glaucoma. The discovery phase of the study was carried out in the TwinsUK cohort (N = 2774) analyzing association between IOP and single nucleotide polymorphisms (SNPs) imputed to HapMap2. The results were validated in 12 independent replication cohorts of European ancestry (combined N = 22 789) that were a part of the International Glaucoma Genetics Consortium. Expression quantitative trait locus (eQTL) analyses of the significantly associated SNPs were performed using data from the Multiple Tissue Human Expression Resource (MuTHER) Study. In the TwinsUK cohort, IOP was significantly associated with a number of SNPs at 9q33.3 (P = 3.48 × 10(-8) for rs2286885, the most significantly associated SNP at this locus), within the genomic sequence of the FAM125B gene. Independent replication in a composite panel of 12 cohorts revealed consistent direction of effect and significant association (P = 0.003, for fixed-effect meta-analysis). Suggestive evidence for an eQTL effect of rs2286885 was observed for one of the probes targeting the coding region of the FAM125B gene. This gene codes for a component of a membrane complex involved in vesicular trafficking process, a function similar to that of the Caveolin genes (CAV1 and CAV2) which have previously been associated with primary open-angle glaucoma. This study suggests a novel association between SNPs in FAM125B and IOP in the TwinsUK cohort, though further studies to elucidate the functional role of this gene in glaucoma are necessary
Socioeconomic position and risk of short-term weight gain: Prospective study of 14,619 middle-aged men and women
No full textBackground: The association between socioeconomic position in middle age and risk of subsequent, short-term weight gain is unknown. We therefore assessed this association in a prospective population based cohort study in Norfolk, UK.Methods: We analysed data on 14,619 middle-aged men and women (aged between 40-75 at baseline) with repeated objective measures of weight and height at baseline (1993-1997) and follow up (1998-2000).Results: During follow up 5,064 people gained more than 2.5 kg. Compared with the highest social class, individuals in the lowest social class had around a 30% greater risk of gaining more than 2.5 kg (OR 1.29; 95% CI 1.11-1.51; p for trend = 0.002). This association remained statistically significant following adjustment for sex, age, baseline BMI, smoking, and follow up time (OR 1.25; CI 1.07-1.46; p for trend < 0.001). We also found no material difference between unadjusted models and those including all confounders and potential mediators.Conclusion: Individuals of low socioeconomic position are at greatest risk of gaining weight during middle age, which is not explained by classical correlates of socioeconomic position and risk factors for obesity
Dietary dairy product intake and incident type 2 diabetes: a prospective study using dietary data from a 7-day food diary
No full textThe consumption of specific dairy types may be beneficial for the prevention of diabetes.
Abstract: The aim of this study was to investigate the association between total and types of dairy product intake and risk of developing incident type 2 diabetes, using a food diary.
Methods: A nested case-cohort within the EPIC-Norfolk Study was examined, including a random subcohort
(n=4,000) and cases of incident diabetes (n=892, including 143 cases in the subcohort) followed-up for 11 years. Diet was assessed using a prospective 7-day food diary. Total dairy intake (g/day) was estimated and categorised into high-fat
(≥3.9%) and low-fat (<3.9% fat) dairy, and by subtype into yoghurt, cheese and milk. Combined fermented dairy product
intake (yoghurt, cheese, sour cream) was estimated and categorised into high- and low-fat. Prentice-weighted Cox
regression HRs were calculated.
Results: Total dairy, high-fat dairy, milk, cheese and high-fat fermented dairy product intakes were not associated with the
development of incident diabetes. Low-fat dairy intake was inversely associated with diabetes in age- and sex-adjusted
analyses (tertile [T] 3 vs T1, HR 0.81 [95% CI 0.66, 0.98]), but further adjustment for anthropometric, dietary and diabetes
risk factors attenuated this association. In addition, an inverse association was found between diabetes and low-fat
fermented dairy product intake (T3 vs T1, HR 0.76 [95% CI 0.60, 0.99]; ptrend=0.049) and specifically with yoghurt intake
(HR 0.72 [95% CI 0.55, 0.95]; ptrend=0.017) in multivariable adjusted analyses.
Conclusions/interpretation: Greater low-fat fermented dairy product intake, largely driven by yoghurt intake, was associated with a decreased risk of type 2 diabetes development in prospective analyses. These findings suggest that the consumption of specific dairy types may be beneficial for the prevention of diabetes, highlighting the importance of food
group subtypes for public health messages
Thyroid function within the normal range, subclinical hypothyroidism and the risk of atrial fibrillation
No full textBackground -Atrial fibrillation (AF) is a highly prevalent disorder leading to heart failure, stroke, and death. Enhanced understanding of modifiable risk factors may yield opportunities for prevention. The risk of AF is increased in subclinical hyperthyroidism, but it is uncertain whether variations in thyroid function within the normal range or subclinical hypothyroidism are also associated with AF. Methods -We conducted a systematic review and obtained individual participant data from prospective cohort studies that measured thyroid function at baseline and assessed incident AF. Studies were identified from MEDLINE and EMBASE databases from inception to July 27, 2016. The euthyroid state was defined as thyroid-stimulating hormone (TSH) 0.45 to 4.49 mIU/L, and subclinical hypothyroidism as TSH 4.5 to 19.9 mIU/L with free thyroxine (fT4) levels within reference range. The association of TSH levels in the euthyroid and subclinical hypothyroid range with incident AF was examined by using Cox proportional hazards models. In euthyroid participants, we additionally examined the association between fT4 levels and incident AF. Results -Of 30 085 participants from 11 cohorts (278 955 person-years of follow-up), 1958 (6.5%) had subclinical hypothyroidism and 2574 individuals (8.6%) developed AF during follow-up. TSH at baseline was not significantly associated with incident AF in euthyroid participants or those with subclinical hypothyroidism. Higher fT4 levels at baseline in euthyroid individuals were associated with increased AF risk in ageand sex-adjusted analyses (hazard ratio, 1.45; 95% confidence interval, 1.26-1.66, for the highest quartile versus the lowest quartile of fT4; P for trend ≤0.001 across quartiles). Estimates did not substantially differ after further adjustment for preexisting cardiovascular disease. Conclusions -In euthyroid individuals, higher circulating fT4 levels, but not TSH levels, are associated with increased risk of incident AF
Obesity indices and self-reported functional health in men and women in the EPIC-Norfolk
No full textTo investigate the association between two indices of obesity, BMI and waist-to-hip ratio (WHR), and self-reported physical and mental functional health
- …
