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Membrane modifications in the course of hepatocyte isolation.
Full text linkA transmission E/2VI, scanning E/M and freeze fracture ultrastructural study has been performed on the
rat hepatocyte in the course of isolation from the liver parenchyma.
The cell submicroscopic aspect indicates a good morpho-functional preservation from the liver
perfusion to the final stages of cell isolation.
The freeze fracture membrane analysis evidentiates the constant presence of gap junctions and tight
junctions, characterized by particular structural alterations, probably due to progressive functional
uncoupling. The persistence of these cell differentiations until complete cell isolation may be considered
a further morphological expression of the maintenance of the differentiated stage of the hepatocyte.
Fragments of membranes from adjacent cells, still adherent to isolated hepatocyte surfaces, can also be
occasionally detected by freeze-fracture techniques
Image analysis of the topological organization of the nuclear domains in freeze-fractured hepatocytes and lymphocytes.
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Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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